Mark W. Youngblood
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View article: Subgroup of meningiomas involving FOS and FOSB gene fusions
Subgroup of meningiomas involving FOS and FOSB gene fusions Open
Meningiomas are the most common primary tumors of the central nervous system and are typically treated with surgery or radiation, as targeted therapies remain limited. Despite extensive study, seventeen percent of meningiomas lack known ge…
View article: Supplementary Figures from Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma
Supplementary Figures from Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma Open
All Supplementary Figures
View article: TableS4 from Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma
TableS4 from Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma Open
Patient Sample WGS data statistics
View article: TableS1 from Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma
TableS1 from Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma Open
Patient Sample Information
View article: TableS3 from Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma
TableS3 from Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma Open
Patient Sample Hi-C data Statistics
View article: TableS5 from Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma
TableS5 from Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma Open
Sequence Data Information in Lipo863B
View article: EPCO-42. RECURRENT LMNA-FOSB FUSIONS ALTER CHROMATIN TOPOLOGY AND GENE REGULATION IN MENINGIOMAS
EPCO-42. RECURRENT LMNA-FOSB FUSIONS ALTER CHROMATIN TOPOLOGY AND GENE REGULATION IN MENINGIOMAS Open
Meningiomas are among the most prevalent tumors of the central nervous system and are typically driven by a limited set of mutually exclusive genetic alterations. We report molecular characterization of seven meningiomas with fusions betwe…
View article: IMMU-24. CHEK2 haploinsufficiency drives immune responsiveness in aggressive meningiomas
IMMU-24. CHEK2 haploinsufficiency drives immune responsiveness in aggressive meningiomas Open
Meningiomas account for more than 30% of all primary central nervous system (CNS) tumors. Although approximately 80% of meningiomas are benign (WHO Grade 1), the remaining 20%, which include Grade 2 and 3 tumors, exhibit poor progression-f…
View article: NOTCH3 drives fatty acid oxidation and ferroptosis resistance in aggressive meningiomas
NOTCH3 drives fatty acid oxidation and ferroptosis resistance in aggressive meningiomas Open
View article: Development, validation, and utility of a clinically applicable methylation classifier for recurrence risk prediction in meningiomas
Development, validation, and utility of a clinically applicable methylation classifier for recurrence risk prediction in meningiomas Open
Meningiomas are common intracranial tumors with complex behavior that can be difficult to predict. Historically, morphology has been used to predict tumor aggressiveness and risk of recurrence, but this strategy has limitations as a progno…
View article: Primary papillary epithelial tumor of the sella harboring an EZH2 Y646F mutation
Primary papillary epithelial tumor of the sella harboring an EZH2 Y646F mutation Open
View article: NOTCH3 Drives Fatty Acid Oxidation and Ferroptosis Resistance in Aggressive Meningiomas
NOTCH3 Drives Fatty Acid Oxidation and Ferroptosis Resistance in Aggressive Meningiomas Open
PURPOSE NOTCH3 is increasingly implicated for its oncogenic role in many malignancies, including meningiomas. While prior work has linked NOTCH3 expression to higher-grade meningiomas and treatment resistance, the metabolic phenotype of NO…
View article: Spatial 3D genome organization reveals intratumor heterogeneity in primary glioblastoma samples
Spatial 3D genome organization reveals intratumor heterogeneity in primary glioblastoma samples Open
Glioblastoma (GBM) is the most prevalent malignant brain tumor with poor prognosis. Although chromatin intratumoral heterogeneity is a characteristic feature of GBM, most current studies are conducted at a single tumor site. To investigate…
View article: The Impact of TERT Promoter Mutation on Meningioma Outcome is Context-Dependent: Implications for Clinical Grading and Risk Stratification
The Impact of TERT Promoter Mutation on Meningioma Outcome is Context-Dependent: Implications for Clinical Grading and Risk Stratification Open
View article: Endothelial response to blood-brain barrier disruption in the human brain
Endothelial response to blood-brain barrier disruption in the human brain Open
Cerebral endothelial cell (EC) injury and blood-brain barrier (BBB) permeability contribute to neuronal injury in acute neurological disease states. Preclinical experiments have used animal models to study this phenomenon, yet the response…
View article: TableS3 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma
TableS3 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma Open
Patient Sample Hi-C data Statistics
View article: Supplementary Figures from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma
Supplementary Figures from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma Open
All Supplementary Figures
View article: TableS5 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma
TableS5 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma Open
Sequence Data Information in Lipo863B
View article: TableS1 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma
TableS1 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma Open
Patient Sample Information
View article: TableS4 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma
TableS4 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma Open
Patient Sample WGS data statistics
View article: Data from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma
Data from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma Open
Liposarcoma (LPS) is the most common soft-tissue sarcoma in adults with two major subtypes, well differentiated and dedifferentiated. Both subtypes are characterized with the pathognomonic giant ring or marker chromosomes that harbor high …
View article: TableS2 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma
TableS2 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma Open
H3K27Ac ChIP-seq Patient Sample Statistics
View article: TableS2 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma
TableS2 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma Open
H3K27Ac ChIP-seq Patient Sample Statistics
View article: TableS4 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma
TableS4 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma Open
Patient Sample WGS data statistics
View article: TableS1 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma
TableS1 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma Open
Patient Sample Information
View article: Supplementary Figures from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma
Supplementary Figures from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma Open
All Supplementary Figures
View article: TableS3 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma
TableS3 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma Open
Patient Sample Hi-C data Statistics
View article: TableS5 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma
TableS5 from Enhancer co-amplification and hijacking promote oncogene expression in liposarcoma Open
Sequence Data Information in Lipo863B
View article: Frailty indices predict mortality, complications and functional improvements in supratentorial meningioma patients over 80 years of age
Frailty indices predict mortality, complications and functional improvements in supratentorial meningioma patients over 80 years of age Open
View article: Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma Open
Treatment of the tumor and dural margin with surgery and sometimes radiation are cornerstones of therapy for meningioma. Molecular classifications have provided insights into the biology of disease; however, response to treatment remains h…