Christopher M. Waters
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View article: Stem cells, cell therapies, and bioengineering in lung biology and diseases 2023
Stem cells, cell therapies, and bioengineering in lung biology and diseases 2023 Open
Repair and regeneration of a diseased lung using stem cells or bioengineered tissues is an exciting therapeutic approach for a variety of lung diseases and critical illnesses. Over the past decade, increasing evidence from preclinical mode…
View article: Two-pore potassium channel TREK-1 (K<scp>2</scp>P<scp>2.1</scp>) regulates NLRP<scp>3</scp> inflammasome activity in macrophages
Two-pore potassium channel TREK-1 (K<span>2</span>P<span>2.1</span>) regulates NLRP<span>3</span> inflammasome activity in macrophages Open
Because of the importance of potassium efflux in inflammasome activation, we investigated the role of the two-pore potassium (K2P) channel TREK-1 in macrophage inflammasome activity. Using primary alveolar macrophages and bone marrow-deriv…
View article: Deficiency of Acute-Phase Serum Amyloid A Exacerbates Sepsis-Induced Mortality and Lung Injury in Mice
Deficiency of Acute-Phase Serum Amyloid A Exacerbates Sepsis-Induced Mortality and Lung Injury in Mice Open
Serum amyloid A (SAA) is a family of proteins, the plasma levels of which may increase >1000-fold in acute inflammatory states. We investigated the role of SAA in sepsis using mice deficient in all three acute-phase SAA isoforms (SAA-TKO).…
View article: Targeting the Microbiome to Improve Gut Health and Breathing Function After Spinal Cord Injury
Targeting the Microbiome to Improve Gut Health and Breathing Function After Spinal Cord Injury Open
Spinal cord injury (SCI) is a devastating condition characterized by impaired motor and sensory function, as well as internal organ pathology and dysfunction. This internal organ dysfunction, particularly gastrointestinal (GI) complication…
View article: Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis
Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis Open
Matrix assisted laser desorption/ionization imaging has greatly improved our understanding of spatial biology, however a robust bioinformatic pipeline for data analysis is lacking. Here, we demonstrate the application of high-dimensionalit…
View article: Activation of a<i>Vibrio cholerae</i>CBASS anti-phage system by quorum sensing and folate depletion
Activation of a<i>Vibrio cholerae</i>CBASS anti-phage system by quorum sensing and folate depletion Open
A major challenge faced by bacteria is infection by bacteriophage (phage). Abortive infection is one strategy for combating phage in which an infected cell kills itself to limit phage replication, thus protecting neighboring kin. One class…
View article: Data from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Data from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Autotaxin (ENPP2/ATX) and lysophosphatidic acid (LPA) receptors represent two key players in regulating cancer progression. The present study sought to understand the mechanistic role of LPA G protein–coupled receptors (GPCR), not only in …
View article: Supplementary Figure 2 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Figure 2 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Figure 2. LPA1-5 receptor profiling in whole lung tissue isolated from WT, LPA1-, LPA2- and LPA5KO mice, respectively using quantitative real-time PCR. Data are expressed as mean {plus minus} SEM (n = 3 mice).
View article: Supplementary Table 1 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Table 1 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Table 1. Primer sequences used in quantitative Real-Time PCR analysis.
View article: Supplementary Figure 4 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Figure 4 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Figure 4. Effect of BMP22 on the basal invasion of B16F10 cells across a matrigel layer. Data are representative of an experiment performed twice in quadruplicates and are expressed as mean {plus minus} SD. *Denotes p value <…
View article: Supplementary Figure 3 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Figure 3 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Figure 3. (A) ATX and LPA receptor profiling in B16F10 cells transduced with GFP lentivirus using quantitative real-time PCR. Data are expressed as mean {plus minus} SD of an experiment performed twice in quadruplicates. (B) …
View article: Data from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Data from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Autotaxin (ENPP2/ATX) and lysophosphatidic acid (LPA) receptors represent two key players in regulating cancer progression. The present study sought to understand the mechanistic role of LPA G protein–coupled receptors (GPCR), not only in …
View article: Supplementary Figure 1 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Figure 1 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Figure 1. Time course of ATX activity measured in the conditioned media (CM) of (A) MM1 rat hepatocarcinoma, (B) HUVEC, (C) RLMVEC, and (D) isolated murine mesothelial cells. Control represents media that were not exposed to …
View article: Supplemental Figure Legends from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplemental Figure Legends from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplemental Figure Legends. Supplemental Figure Legends
View article: Supplementary Figure 1 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Figure 1 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Figure 1. Time course of ATX activity measured in the conditioned media (CM) of (A) MM1 rat hepatocarcinoma, (B) HUVEC, (C) RLMVEC, and (D) isolated murine mesothelial cells. Control represents media that were not exposed to …
View article: Supplemental Figure Legends from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplemental Figure Legends from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplemental Figure Legends. Supplemental Figure Legends
View article: Supplementary Figure 3 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Figure 3 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Figure 3. (A) ATX and LPA receptor profiling in B16F10 cells transduced with GFP lentivirus using quantitative real-time PCR. Data are expressed as mean {plus minus} SD of an experiment performed twice in quadruplicates. (B) …
View article: Supplementary Figure 5 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Figure 5 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Figure 5. ATX and LPA receptor profiling in isolated rat alveolar type I-like (A) or type II (B) epithelial cells. Note that expression levels in type II alveolar cells are approximately 10-fold lower than in type I-like cell…
View article: Supplementary Figure 5 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Figure 5 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Figure 5. ATX and LPA receptor profiling in isolated rat alveolar type I-like (A) or type II (B) epithelial cells. Note that expression levels in type II alveolar cells are approximately 10-fold lower than in type I-like cell…
View article: Data from Tyrosine Kinase Inhibitor Gefitinib Enhances Topotecan Penetration of Gliomas
Data from Tyrosine Kinase Inhibitor Gefitinib Enhances Topotecan Penetration of Gliomas Open
Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, increases brain parenchymal extracellular fluid (ECF) accumulation of topotecan, a substrate of the ATP-binding cassette (ABC) transporters P-glycoprotein (Pgp/MDR-1…
View article: Supplementary Methods from Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid
Supplementary Methods from Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid Open
Supplementary Methods from Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid
View article: Supplementary Figure 1 from Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid
Supplementary Figure 1 from Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid Open
Supplementary Figure 1 from Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid
View article: Data from Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid
Data from Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid Open
Topotecan is a substrate of the ATP-binding cassette transporters P-glycoprotein (P-gp/MDR1) and breast cancer resistance protein (BCRP). To define the role of these transporters in topotecan penetration into the ventricular cerebrospinal …
View article: Data from Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid
Data from Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid Open
Topotecan is a substrate of the ATP-binding cassette transporters P-glycoprotein (P-gp/MDR1) and breast cancer resistance protein (BCRP). To define the role of these transporters in topotecan penetration into the ventricular cerebrospinal …
View article: Data from Tyrosine Kinase Inhibitor Gefitinib Enhances Topotecan Penetration of Gliomas
Data from Tyrosine Kinase Inhibitor Gefitinib Enhances Topotecan Penetration of Gliomas Open
Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, increases brain parenchymal extracellular fluid (ECF) accumulation of topotecan, a substrate of the ATP-binding cassette (ABC) transporters P-glycoprotein (Pgp/MDR-1…
View article: Supplementary Figure 1 from Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid
Supplementary Figure 1 from Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid Open
Supplementary Figure 1 from Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid
View article: Supplementary Figure 1 from Tyrosine Kinase Inhibitor Gefitinib Enhances Topotecan Penetration of Gliomas
Supplementary Figure 1 from Tyrosine Kinase Inhibitor Gefitinib Enhances Topotecan Penetration of Gliomas Open
Supplementary Figure 1 from Tyrosine Kinase Inhibitor Gefitinib Enhances Topotecan Penetration of Gliomas
View article: Supplementary Methods from Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid
Supplementary Methods from Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid Open
Supplementary Methods from Compartment-Specific Roles of ATP-Binding Cassette Transporters Define Differential Topotecan Distribution in Brain Parenchyma and Cerebrospinal Fluid
View article: Supplementary Methods from Tyrosine Kinase Inhibitor Gefitinib Enhances Topotecan Penetration of Gliomas
Supplementary Methods from Tyrosine Kinase Inhibitor Gefitinib Enhances Topotecan Penetration of Gliomas Open
Supplementary Methods from Tyrosine Kinase Inhibitor Gefitinib Enhances Topotecan Penetration of Gliomas