Mark Weatherall
YOU?
Author Swipe
View article: UK Medical Cannabis Registry: An Updated Analysis of Cannabis-Based Medicinal Products for Multiple Sclerosis
UK Medical Cannabis Registry: An Updated Analysis of Cannabis-Based Medicinal Products for Multiple Sclerosis Open
Introduction Multiple sclerosis (MS) is a neurodegenerative disease presenting with a wide range of motor, sensory and psychiatric symptoms. Although nabiximols is licensed for MS-induced spasticity, cannabis-based medicinal products (CBMP…
View article: An anti-inflammatory reliever algorithm approach to asthma management in adults: an open-label, single-arm trial
An anti-inflammatory reliever algorithm approach to asthma management in adults: an open-label, single-arm trial Open
View article: Needle length selection for intramuscular vaccine administration: Time for an evidence-based approach
Needle length selection for intramuscular vaccine administration: Time for an evidence-based approach Open
View article: Cost-effectiveness of as-needed budesonide-formoterol in adults with mild asthma: Novel START trial
Cost-effectiveness of as-needed budesonide-formoterol in adults with mild asthma: Novel START trial Open
Background The Global Initiative for Asthma strategy recommends as-needed combination inhaled corticosteroid (ICS)-formoterol reliever for mild asthma. Its cost-effectiveness is uncertain outside of double-blind regulatory trials. Objectiv…
View article: UK Medical Cannabis Registry: A clinical outcomes analysis for insomnia
UK Medical Cannabis Registry: A clinical outcomes analysis for insomnia Open
Insomnia affects approximately 10% of adults globally. Current treatments have their limitations, and there is growing evidence on the therapeutic potential of cannabis-based medicinal products for insomnia. This study aimed to assess chan…
View article: Long term follow-up of participants in the Taking Charge after Stroke randomised controlled trial
Long term follow-up of participants in the Taking Charge after Stroke randomised controlled trial Open
Background The Take Charge intervention – a conversation-based, community intervention to improve motivation, improved independence and physical health 12 months after stroke in two randomised controlled trials with 572 participants. This …
View article: He Rourou Whai Painga; A collaborative community-based research partnership testing the impact of a New Zealand Mediterranean dietary pattern on cardiometabolic health and wellbeing
He Rourou Whai Painga; A collaborative community-based research partnership testing the impact of a New Zealand Mediterranean dietary pattern on cardiometabolic health and wellbeing Open
Cardiometabolic diseases, including type 2 diabetes (T2DM) and cardiovascular disease (CVD), are common. Approximately one in three deaths annually are caused by CVD in Aotearoa New Zealand (AoNZ) (1) . The Mediterranean dietary pattern is…
View article: UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Epilepsy
UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Epilepsy Open
Background A third of epilepsy patients fail to enter seizure remission despite optimal therapeutic management. Cannabis‐based medicinal products (CBMPs) have shown promise as a potential therapy. However, a paucity of high‐quality literat…
View article: Treatable Trait Guided Asthma Management: A Feasibility Study
Treatable Trait Guided Asthma Management: A Feasibility Study Open
Background and Objectives Treatable trait‐based personalised medicine improves outcomes in severe asthma clinics. We assessed the feasibility of a randomised controlled trial (RCT) of protocolised treatable trait‐guided asthma management i…
View article: Protocol for the INFORM ASTHMA Trial: budesonide–formoterol reliever in adults with asthma on maintenance inhaled corticosteroid
Protocol for the INFORM ASTHMA Trial: budesonide–formoterol reliever in adults with asthma on maintenance inhaled corticosteroid Open
Background International asthma guidelines recommend inhaled corticosteroid (ICS)/formoterol in preference to short-acting β 2 -agonist (SABA) reliever-based regimens as reliever therapy in adults and adolescents of all asthma severities. …
View article: An Anti-Inflammatory Reliever Algorithm Approach to Asthma Management in Adults
An Anti-Inflammatory Reliever Algorithm Approach to Asthma Management in Adults Open
View article: Did you know... that 43.5% of New Zealand women report at least some urinary incontinence?
Did you know... that 43.5% of New Zealand women report at least some urinary incontinence? Open
A recent publication in the New Zealand Medical Journal identified that 43.5% of New Zealand women between the ages of 16 and 74 report at least some urinary incontinence.
View article: 239 - What is the most effective pelvic floor muscle training type, dose, and delivery method for females with urinary incontinence? A Cochrane review with meta-analysis
239 - What is the most effective pelvic floor muscle training type, dose, and delivery method for females with urinary incontinence? A Cochrane review with meta-analysis Open
View article: The evidence base for ICS/formoterol maintenance and reliever therapy in severe asthma
The evidence base for ICS/formoterol maintenance and reliever therapy in severe asthma Open
ICS/formoterol MART is an evidence-based alternative to high dose ICS/LABA in asthma patients at high risk of severe exacerbations; limited generalisability of RCTs to severe asthma registries applies similarly to high dose ICS/LABA therap…
View article: Automated oxygen titration with non-invasive ventilation in hypoxaemic adults with cardiorespiratory disease: a randomised cross-over trial
Automated oxygen titration with non-invasive ventilation in hypoxaemic adults with cardiorespiratory disease: a randomised cross-over trial Open
Background Closed-loop oxygen control systems automatically adjust the fraction of inspired oxygen (FiO 2 ) to maintain oxygen saturation (SpO 2 ) within a predetermined target range. Their performance with low and high-flow oxygen therapi…
View article: Primary spontaneous pneumothorax: does size matter?
Primary spontaneous pneumothorax: does size matter? Open
There is increasing evidence supporting conservative management for patients with primary spontaneous pneumothorax (PSP) regardless of size [1, 2] which is reflected in the recent British Thoracic Society Guideline [3]. However, the size o…
View article: Clinical outcome analysis of patients with multiple sclerosis – Analysis from the UK Medical Cannabis Registry
Clinical outcome analysis of patients with multiple sclerosis – Analysis from the UK Medical Cannabis Registry Open
This preliminary analysis demonstrates a possible association with improved general health-related quality of life in those prescribed CBMPs for MS. Moreover, the results suggest that CBMPs are well-tolerated in the first 6 months of treat…
View article: Patterns of asthma medication use and hospital discharges in New Zealand
Patterns of asthma medication use and hospital discharges in New Zealand Open
View article: He Rourou Whai Painga, an Aotearoa New Zealand Dietary Pattern for Metabolic Health and Whānau Wellbeing: Protocol for a randomised controlled trial
He Rourou Whai Painga, an Aotearoa New Zealand Dietary Pattern for Metabolic Health and Whānau Wellbeing: Protocol for a randomised controlled trial Open
Cardiometabolic diseases are highly prevalent in Aotearoa New Zealand (1) . Dietary intake is a modifiable risk factor for such diseases and certain dietary patterns, specifically the Mediterranean diet (MedDiet), are associated with impro…
View article: START CARE: a protocol for a randomised controlled trial of step-wise budesonide–formoterol reliever-based treatment in children
START CARE: a protocol for a randomised controlled trial of step-wise budesonide–formoterol reliever-based treatment in children Open
Background Asthma is the most common chronic childhood respiratory condition globally. Inhaled corticosteroid (ICS)–formoterol reliever-based regimens reduce the risk of asthma exacerbations compared with conventional short-acting β 2 -ago…
View article: Effect of a lower target oxygen saturation range on the risk of hypoxaemia and elevated NEWS2 scores at a university hospital: a retrospective study
Effect of a lower target oxygen saturation range on the risk of hypoxaemia and elevated NEWS2 scores at a university hospital: a retrospective study Open
Background The optimal target oxygen saturation (SpO 2 ) range for hospital inpatients not at risk of hypercapnia is unknown. The objective of this study was to assess the impact on oxygen usage and National Early Warning Score 2 (NEWS2) o…
View article: UK Medical Cannabis Registry: Assessment of clinical outcomes in patients with insomnia
UK Medical Cannabis Registry: Assessment of clinical outcomes in patients with insomnia Open
Introduction The primary aim of this study was to assess changes in sleep‐specific health‐related quality of life (HRQoL) for those prescribed cannabis‐based medicinal products (CBMPs) for insomnia. Methods A case series of UK patients wit…
View article: Intramuscular vaccination needle length: a call to arms
Intramuscular vaccination needle length: a call to arms Open
View article: Eye movement desensitization and reprocessing (EMDR) therapy compared to usual treatment for posttraumatic stress disorder in adults with psychosis in forensic settings: Randomized controlled trial.
Eye movement desensitization and reprocessing (EMDR) therapy compared to usual treatment for posttraumatic stress disorder in adults with psychosis in forensic settings: Randomized controlled trial. Open
This is the first EMDR trial in mental health inpatient, forensic, or custodial settings, where PTSD is common. There were improvements in PTSD and other symptomatology consistent with EMDR being a safe and effective treatment for PTSD in …
View article: He Rourou Whai Painga, an Aotearoa New Zealand dietary pattern for metabolic health and whānau wellbeing: protocol for a randomized controlled trial
He Rourou Whai Painga, an Aotearoa New Zealand dietary pattern for metabolic health and whānau wellbeing: protocol for a randomized controlled trial Open
Background Cardiometabolic diseases are highly prevalent in Aotearoa New Zealand. Dietary intake is a modifiable risk factor for such diseases and certain dietary patterns, specifically the Mediterranean diet (MedDiet), are associated with…
View article: A high quality Aotearoa New Zealand dietary pattern adapting a Mediterranean diet for metabolic health: a feasibility study
A high quality Aotearoa New Zealand dietary pattern adapting a Mediterranean diet for metabolic health: a feasibility study Open
Aim To assess the feasibility of a family-based dietary intervention study using a meal kit home delivery service, in people at risk of cardio-metabolic disease. Methods A 12-week dietary intervention feasibility study of adults (termed th…
View article: An observational study of clinical outcome measures in patients treated with cannabis‐based medicinal products on the <scp>UK</scp> Medical Cannabis Registry
An observational study of clinical outcome measures in patients treated with cannabis‐based medicinal products on the <span>UK</span> Medical Cannabis Registry Open
Introduction While there is increasing evidence of the effects of cannabis‐based medicinal products (CBMPs) on health‐related quality of life (HRQoL), a major limitation of the current literature is the heterogeneity of studied CBMPs. This…
View article: Clinical remission with biologic therapies in severe asthma: a matter of definition
Clinical remission with biologic therapies in severe asthma: a matter of definition Open
Tweetable abstract Biologic agents have transformed the treatment of severe asthma; however, whether they can induce remission remains to be determined. A crucial early step will be to define the specific criteria of disease remission, …
View article: P166 External validation of the minimal clinically important difference of fractional exhaled nitric oxide using the asthma control questionnaire: a secondary analysis of two RCTs in mild or moderate asthma
P166 External validation of the minimal clinically important difference of fractional exhaled nitric oxide using the asthma control questionnaire: a secondary analysis of two RCTs in mild or moderate asthma Open
Introduction The utility of fractional exhaled nitric oxide (FeNO) in randomised controlled trials (RCTs) of asthma, particularly the minimal clinical important difference (MCID), is uncertain. The American Thoracic Society recommends that…
View article: Eye movement Desensitization and Re-processing (EMDR) Therapy Compared to Usual Treatment for Post-Traumatic Stress Disorder in Adults with Psychosis in Forensic Settings: Randomized Controlled Trial (PREPRINT)
Eye movement Desensitization and Re-processing (EMDR) Therapy Compared to Usual Treatment for Post-Traumatic Stress Disorder in Adults with Psychosis in Forensic Settings: Randomized Controlled Trial (PREPRINT) Open
Objective: Little direct evidence supports any particular treatment for post-traumatic stress disorder (PTSD) in people with schizophrenia, forensic histories, and/or multiple comorbidities. This trial assesses the efficacy and risks of Ey…