Mark Woolhouse
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View article: Genomic profiling of enterotoxigenic Escherichia coli toxins and adhesins in livestock isolates from Kenya
Genomic profiling of enterotoxigenic Escherichia coli toxins and adhesins in livestock isolates from Kenya Open
Enterotoxigenic Escherichia coli (ETEC) is a significant cause of diarrhoea in livestock and humans. The epidemiology of ETEC in animals remains understudied, prompting an investigation into the virulence factors and associated adhesins of…
View article: Evaluation of the epidemic intelligence from open sources (EIOS) system for the early detection of outbreaks and health emergencies in the African region
Evaluation of the epidemic intelligence from open sources (EIOS) system for the early detection of outbreaks and health emergencies in the African region Open
We conclude that the EIOS system performed well in detecting public health events in the African region early. However, some improvements are needed. We recommend increasing social media and local community radio sources on the EIOS system.
View article: Modelling COVID-19 transmission dynamics in Laos under non-pharmaceutical interventions, vaccination, and replacement of SARS-CoV-2 variants
Modelling COVID-19 transmission dynamics in Laos under non-pharmaceutical interventions, vaccination, and replacement of SARS-CoV-2 variants Open
Background Understanding how the COVID-19 pandemic evolved under control measures is crucial to tackle the SARS-CoV-2 virus spread. Laos, a country bordering China but with late occurrence and low burden of COVID-19 compared to its neighbo…
View article: West Nile virus spread in Europe: Phylogeographic pattern analysis and key drivers
West Nile virus spread in Europe: Phylogeographic pattern analysis and key drivers Open
Background West Nile virus (WNV) outbreaks in birds, humans, and livestock have occurred in multiple areas in Europe and have had a significant impact on animal and human health. The patterns of emergence and spread of WNV in Europe are ve…
View article: Temporal Dynamics, Discovery, and Emergence of Human-Transmissible RNA Viruses
Temporal Dynamics, Discovery, and Emergence of Human-Transmissible RNA Viruses Open
Transmissibility, the ability to spread within host populations, is a prerequisite for a pathogen to have epidemic or pandemic potential. Here, we estimate the phylogenies of human infectivity and transmissibility using 1,408 genome sequen…
View article: Analysis of Escherichia coli O157 strains in cattle and humans between Scotland and England & Wales: implications for human health
Analysis of Escherichia coli O157 strains in cattle and humans between Scotland and England & Wales: implications for human health Open
For the last two decades, the human infection frequency of Escherichia coli O157 (O157) in Scotland has been 2.5-fold higher than in England and Wales. Results from national cattle surveys conducted in Scotland and England and Wales in 201…
View article: Epidemiological connectivity between humans and animals across an urban landscape
Epidemiological connectivity between humans and animals across an urban landscape Open
Urbanization is predicted to be a key driver of disease emergence through human exposure to novel, animal-borne pathogens. However, while we suspect that urban landscapes are primed to expose people to novel animal-borne diseases, evidence…
View article: What does equitable global health research and delivery look like? Tackling Infections to Benefit Africa (TIBA) partnership as a case study
What does equitable global health research and delivery look like? Tackling Infections to Benefit Africa (TIBA) partnership as a case study Open
There is a current global push to identify and implement best practice for delivering maximum impact from development research in low-income and middle-income countries. Here, we describe a model of research and capacity building that chal…
View article: Peptide microarray IgM and IgG screening of pre-SARS-CoV-2 human serum samples from Zimbabwe for reactivity with peptides from all seven human coronaviruses: a cross-sectional study
Peptide microarray IgM and IgG screening of pre-SARS-CoV-2 human serum samples from Zimbabwe for reactivity with peptides from all seven human coronaviruses: a cross-sectional study Open
BACKGROUND: SARS-CoV-2 infections and deaths have been lower in Africa than in other continents, which could be attributed to previous exposure to other pathogens that induce protective cross-immunity or modify the immune phenotype. We aim…
View article: West Nile Virus spread in Europe - phylogeographic pattern analysis and key drivers
West Nile Virus spread in Europe - phylogeographic pattern analysis and key drivers Open
Spread and emergence of West Nile virus (WNV) in Europe have been very different from those observed in North America. Here, we describe key drivers by combining viral genome sequences with epidemiological data and possible factors of spre…
View article: The Role of the Environment in Dynamics of Antibiotic Resistance in Humans and Animals: A Modelling Study
The Role of the Environment in Dynamics of Antibiotic Resistance in Humans and Animals: A Modelling Study Open
Antibiotic resistance is transmitted between animals and humans either directly or indirectly, through transmission via the environment. However, little is known about the contribution of the environment to resistance epidemiology. Here, w…
View article: Draft Genome Sequence of an Enterotoxigenic Escherichia coli Strain Carrying Genes for Colonization Surface Antigen 13 and a Heat-Labile Toxin
Draft Genome Sequence of an Enterotoxigenic Escherichia coli Strain Carrying Genes for Colonization Surface Antigen 13 and a Heat-Labile Toxin Open
Here, we report the draft genome of ESEI_597, an enterotoxigenic Escherichia coli (ETEC) strain harboring genes encoding colonization surface antigen 13 (CS13) and a heat-labile toxin. The ESEI_597 strain was isolated from an 8-month-old c…
View article: Predictors of human-infective RNA virus discovery in the United States, China, and Africa, an ecological study
Predictors of human-infective RNA virus discovery in the United States, China, and Africa, an ecological study Open
Background: The variation in the pathogen type as well as the spatial heterogeneity of predictors make the generality of any associations with pathogen discovery debatable. Our previous work confirmed that the association of a group of pre…
View article: The role of the environment in transmission of antimicrobial resistance between humans and animals: a modelling study
The role of the environment in transmission of antimicrobial resistance between humans and animals: a modelling study Open
Background Antimicrobial resistance can be transmitted between animals and humans both directly or indirectly, through transmission via the environment (such as fomites or sewage). However, there is a lack of understanding of, and quantita…
View article: Impact on emergency and elective hospital-based care in Scotland over the first 12 months of the pandemic: interrupted time-series analysis of national lockdowns
Impact on emergency and elective hospital-based care in Scotland over the first 12 months of the pandemic: interrupted time-series analysis of national lockdowns Open
Objectives COVID-19 has resulted in the greatest disruption to National Health Service (NHS) care in its over 70-year history. Building on our previous work, we assessed the ongoing impact of pandemic-related disruption on provision of eme…
View article: Author response: Predictors of human-infective RNA virus discovery in the United States, China, and Africa, an ecological study
Author response: Predictors of human-infective RNA virus discovery in the United States, China, and Africa, an ecological study Open
Article Figures and data Abstract Editor's evaluation Introduction Materials and methods Results Discussion Appendix 1 Appendix 2 Appendix 3 Appendix 4 Data availability References Decision letter Author response Article and author informa…
View article: Population genomics of Escherichia coli in livestock-keeping households across a rapidly developing urban landscape
Population genomics of Escherichia coli in livestock-keeping households across a rapidly developing urban landscape Open
Quantitative evidence for the risk of zoonoses and the spread of antimicrobial resistance remains lacking. Here, as part of the UrbanZoo project, we sampled Escherichia coli from humans, livestock and peri-domestic wildlife in 99 household…
View article: First dose ChAdOx1 and BNT162b2 COVID-19 vaccinations and cerebral venous sinus thrombosis: A pooled self-controlled case series study of 11.6 million individuals in England, Scotland, and Wales
First dose ChAdOx1 and BNT162b2 COVID-19 vaccinations and cerebral venous sinus thrombosis: A pooled self-controlled case series study of 11.6 million individuals in England, Scotland, and Wales Open
Background Several countries restricted the administration of ChAdOx1 to older age groups in 2021 over safety concerns following case reports and observed versus expected analyses suggesting a possible association with cerebral venous sinu…
View article: Supplementary Material for: The Identification and Characterization of Immunoreactive Fungal Proteins Recognized by Sera from Zimbabweans Sensitized to Fungi
Supplementary Material for: The Identification and Characterization of Immunoreactive Fungal Proteins Recognized by Sera from Zimbabweans Sensitized to Fungi Open
Background: Exposure to fungal allergens poses a serious threat to human health, especially to mould-allergic individuals. The prevalence of fungal allergic disease is increasing globally but is poorly studied in Africa. Here, we aimed to …
View article: Association between multimorbidity and mortality in a cohort of patients admitted to hospital with COVID-19 in Scotland
Association between multimorbidity and mortality in a cohort of patients admitted to hospital with COVID-19 in Scotland Open
Objectives We investigated the association between multimorbidity among patients hospitalised with COVID-19 and their subsequent risk of mortality. We also explored the interaction between the presence of multimorbidity and the requirement…
View article: Predictors of human-infective RNA virus discovery in the United States, China and Africa, an ecological study
Predictors of human-infective RNA virus discovery in the United States, China and Africa, an ecological study Open
Background The variation in the pathogen type as well as the spatial heterogeneity of predictors make the generality of any associations with pathogen discovery debatable. Our previous work confirmed that the association of a group of pred…
View article: Secrets of the Hospital Underbelly: Patterns of Abundance of Antimicrobial Resistance Genes in Hospital Wastewater Vary by Specific Antimicrobial and Bacterial Family
Secrets of the Hospital Underbelly: Patterns of Abundance of Antimicrobial Resistance Genes in Hospital Wastewater Vary by Specific Antimicrobial and Bacterial Family Open
Background: Hospital wastewater is a major source of antimicrobial resistance (AMR) outflow into the environment. This study uses metagenomics to study how hospital clinical activity impacts antimicrobial resistance genes (ARGs) abundances…