Mark Zafereo
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View article: 1338 Multi-cohort phase II study of autologous centrally manufactured tumor infiltrating lymphocytes
1338 Multi-cohort phase II study of autologous centrally manufactured tumor infiltrating lymphocytes Open
View article: Patterns of Lateral Lymph Node Involvement by Neck Level in cNIb Differentiated Thyroid Carcinoma: A Systematic Review and Meta-Analysis
Patterns of Lateral Lymph Node Involvement by Neck Level in cNIb Differentiated Thyroid Carcinoma: A Systematic Review and Meta-Analysis Open
Background/Objectives: The optimal extent of lateral lymph node dissection in cN1b differentiated thyroid cancer remains controversial. This systematic review aimed to assess the frequency of lymph node involvement across neck levels I to …
View article: Segmental Tracheal Resection for Thyroid Cancer: Perioperative Morbidity, Locoregional Control, and Survival
Segmental Tracheal Resection for Thyroid Cancer: Perioperative Morbidity, Locoregional Control, and Survival Open
Background Segmental tracheal resection is rarely needed for advanced thyroid cancer but is among the most complex, high‐risk thyroid surgeries. Methods Retrospective study of patients undergoing segmental tracheal resection for thyroid ca…
View article: Molecular Diagnostics and Personalized Therapeutics in Differentiated Thyroid Carcinoma: A Clinically Oriented Review
Molecular Diagnostics and Personalized Therapeutics in Differentiated Thyroid Carcinoma: A Clinically Oriented Review Open
Differentiated thyroid carcinoma (DTC) is the most common endocrine malignancy and typically has a favorable prognosis. However, a subset of patients experience aggressive disease, recurrence, or treatment resistance, underscoring the need…
View article: Management of Retropharyngeal Lymph Node Metastases in Thyroid Cancer
Management of Retropharyngeal Lymph Node Metastases in Thyroid Cancer Open
Background Retropharyngeal lymph node (RPLN) metastases in thyroid cancer are rare, with optimal management underreported. Methods Retrospective study of consecutive thyroid cancer patients with RPLN metastases treated at MD Anderson Cance…
View article: Adjuvant pembrolizumab after upfront multimodal therapy for stage IVB Anaplastic Thyroid Cancer
Adjuvant pembrolizumab after upfront multimodal therapy for stage IVB Anaplastic Thyroid Cancer Open
Background ATC has historically been almost uniformly fatal. In patients with loco-regional disease (stage IVB), multimodal therapy (upfront surgery when feasible, radiation +/-concurrent chemotherapy) followed by observation is the curren…
View article: Role of the ETV5/p38 signaling axis in aggressive thyroid cancer cells
Role of the ETV5/p38 signaling axis in aggressive thyroid cancer cells Open
Patients with poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) face a much poorer prognosis than those with differentiated thyroid cancers. Around 25% of PDTCs and 35% of ATCs carry the BRAF V600E mutation, w…
View article: <i>NTRK</i> Fusion–Positive Thyroid Carcinoma: From Diagnosis to Targeted Therapy
<i>NTRK</i> Fusion–Positive Thyroid Carcinoma: From Diagnosis to Targeted Therapy Open
PURPOSE Neurotrophic tropomyosin receptor kinase ( NTRK ) fusions may act as an oncogenic driver in thyroid carcinomas. Given their low frequency, clinical, pathological, and molecular data on these patients and their responses to targeted…
View article: An anatomic checklist for accurate staging of grossly invasive thyroid cancer
An anatomic checklist for accurate staging of grossly invasive thyroid cancer Open
Objective The final surgical pathology report follows the patient throughout their cancer journey. For locoregionally advanced cancers, lack of surgeon-pathologist communication can lead to understaging, adversely impacting management. Our…
View article: Recurrent Poorly Differentiated Thyroid Cancer Successfully Treated With Radiation and Immunotherapy
Recurrent Poorly Differentiated Thyroid Cancer Successfully Treated With Radiation and Immunotherapy Open
A 65-year-old patient presented with recurrent, locally advanced poorly differentiated thyroid cancer despite 2 neck surgeries, and with newly diagnosed brain and skull base metastases. He was treated with palliative stereotactic radiosurg…
View article: [<sup>18</sup>F]-FDG Uptake as a Marker of Residual Anaplastic and Poorly Differentiated Thyroid Carcinoma following<i>BRAF</i>-Targeted Therapy
[<sup>18</sup>F]-FDG Uptake as a Marker of Residual Anaplastic and Poorly Differentiated Thyroid Carcinoma following<i>BRAF</i>-Targeted Therapy Open
Preoperative FDG-PET noninvasively identifies lesions with residual high-risk pathologies following neoadjuvant BRAF-directed targeted therapy and immunotherapy for BRAF-mutated ATC. FDG-PET avidity may serve as an early prog…
View article: Patterns of loco-regional progression and patient outcomes after definitive-dose radiation therapy for anaplastic thyroid cancer
Patterns of loco-regional progression and patient outcomes after definitive-dose radiation therapy for anaplastic thyroid cancer Open
Despite an intensive treatment schedule, including AF and concurrent chemotherapy, classic radio-resistant and rapid Type A failures predominated; isolated extraneous dose failures were rare. While these findings support the IMRT and TV de…
View article: Anti–Programmed Death Ligand 1 Plus Targeted Therapy in Anaplastic Thyroid Carcinoma
Anti–Programmed Death Ligand 1 Plus Targeted Therapy in Anaplastic Thyroid Carcinoma Open
Importance Anaplastic thyroid carcinoma (ATC) is a rare and lethal cancer. Although progress has been made in recent years in patients with mutated BRAF tumors, those who respond initially eventually die of their disease; furthermore, ther…
View article: 7742 Clinical Outcomes of Thyroid Cancer Patients Enrolled in a Comprehensive Thyroid Cancer Survivorship Program
7742 Clinical Outcomes of Thyroid Cancer Patients Enrolled in a Comprehensive Thyroid Cancer Survivorship Program Open
Disclosure: M.A. Ruiz Santillan: None. J.L. Rollins: None. S. Lee-Kim: None. M.I. Hu: None. S.I. Sherman: None. J. Varghese: None. N.L. Busaidy: None. M. Cabanillas: None. R. Dadu: None. P.C. Iyer: None. A.K. Ying: None. S.G. Waguespack: N…
View article: The Association Between Thyroid Differentiation Score and Survival Outcomes in Papillary Thyroid Carcinoma
The Association Between Thyroid Differentiation Score and Survival Outcomes in Papillary Thyroid Carcinoma Open
Context Thyroid differentiation score (TDS), calculated based on mRNA expression levels of 16 genes controlling thyroid metabolism and function, has been proposed as a measure to quantify differentiation in papillary thyroid carcinoma (PTC…
View article: A positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression
A positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression Open
View article: Emerging therapeutic options for follicular-derived thyroid cancer in the era of immunotherapy
Emerging therapeutic options for follicular-derived thyroid cancer in the era of immunotherapy Open
Although most follicular-derived thyroid cancers are well differentiated and have an overall excellent prognosis following treatment with surgery and radioiodine, management of advanced thyroid cancers, including iodine refractory disease …
View article: Recurrent Laryngeal Nerve Intraoperative Neuromonitoring Indications in Non-Thyroid and Non-Parathyroid Surgery
Recurrent Laryngeal Nerve Intraoperative Neuromonitoring Indications in Non-Thyroid and Non-Parathyroid Surgery Open
Introperative nerve monitoring (IONM) of the recurrent laryngeal nerve (RLN) is a well-established technique to aid in thyroid/parathyroid surgery. However, there is little evidence to support its use in non-thyroid or non-parathyroid surg…
View article: Next-Generation Sequencing in Sporadic Medullary Thyroid Cancer Patients: Mutation Profile and Disease Aggressiveness
Next-Generation Sequencing in Sporadic Medullary Thyroid Cancer Patients: Mutation Profile and Disease Aggressiveness Open
Context Next-generation sequencing (NGS) analysis of sporadic medullary thyroid carcinoma (sMTC) has led to increased detection of somatic mutations, including RET M918T, which has been considered a negative prognostic indicator. Objective…
View article: TGF-β1 and TGF-βR1 variants are associated with clinical outcomes in smoking-related head and neck cancer patients treated with chemoradiation through modulating microRNA-mediated regulation
TGF-β1 and TGF-βR1 variants are associated with clinical outcomes in smoking-related head and neck cancer patients treated with chemoradiation through modulating microRNA-mediated regulation Open
View article: Pediatric Medullary Thyroid Carcinoma: Clinical Presentations and Long-Term Outcomes in 144 Patients Over 6 Decades
Pediatric Medullary Thyroid Carcinoma: Clinical Presentations and Long-Term Outcomes in 144 Patients Over 6 Decades Open
Context Sporadic medullary thyroid carcinoma (sMTC) rarely occurs in childhood and no studies have specifically focused on this entity. Objective To describe the clinical presentations and long-term outcomes of a large cohort of children a…
View article: Lower Rates of Hypocalcemia Following Near-Infrared Autofluorescence Use in Thyroidectomy: A Meta-Analysis of RCTs
Lower Rates of Hypocalcemia Following Near-Infrared Autofluorescence Use in Thyroidectomy: A Meta-Analysis of RCTs Open
Background: Iatrogenic injury of the parathyroid glands is the most frequent complication after total thyroidectomy. Objective: To determine the effectiveness of near-infrared autofluorescence (NIRAF) in reducing postoperative hypocalcemia…
View article: Impact of pretreatment body mass index on the survival of head and neck cancer patients
Impact of pretreatment body mass index on the survival of head and neck cancer patients Open
Background Differences in pretreatment body mass index (BMI) have been associated with survival in squamous cell carcinoma of head and neck (SCCHN). We examined effects of BMI on survival in SCCHN patients after stratifying patients by tum…
View article: Recovery of Recurrent Laryngeal Nerve Function With Neoadjuvant Treatment: Neural Characterization
Recovery of Recurrent Laryngeal Nerve Function With Neoadjuvant Treatment: Neural Characterization Open
Objectives Neoadjuvant targeted therapy has emerged as a promising treatment strategy for locally aggressive thyroid cancer. Its impact on tumor and adjacent tissues remains a nascent area of study. Here we report on a series of six subjec…
View article: Malignant carotid body tumors: What we know, what we do, and what we need to achieve. A systematic review of the literature
Malignant carotid body tumors: What we know, what we do, and what we need to achieve. A systematic review of the literature Open
Malignant carotid body tumors (MCBT) are rare and diagnosed after detection of nodal or distant metastases. This systematic review (SR) focuses on MCBT initially approached by surgery. Preferred Reporting Items for SR and Meta‐Analysis (MA…
View article: Issue Information
Issue Information Open
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View article: Strategies for mitigating adverse events related to selective RET inhibitors in patients with RET-altered cancers
Strategies for mitigating adverse events related to selective RET inhibitors in patients with RET-altered cancers Open
The US Food and Drug Administration (FDA) approval of the selective RET inhibitors selpercatinib and pralsetinib has led to a paradigm change in the treatment of RET-altered lung and thyroid cancers through a higher response rate and a mor…
View article: Patterns of failure for recurrent head and neck squamous cell carcinoma treated with salvage surgery and postoperative IMRT reirradiation
Patterns of failure for recurrent head and neck squamous cell carcinoma treated with salvage surgery and postoperative IMRT reirradiation Open
Our study highlights the role of DIR in enhancing the accuracy and consistency of POF analysis. Compared to traditional visual inspection, DIR reduces interobserver variability and provides more nuanced insights into dose-specific and spat…
View article: 460 Efficacy of adding anti-PD1 immunotherapy to dabrafenib + trametinib (DT) at progression in BRAFv600e mutated anaplastic thyroid carcinoma (BRAFm-ATC)
460 Efficacy of adding anti-PD1 immunotherapy to dabrafenib + trametinib (DT) at progression in BRAFv600e mutated anaplastic thyroid carcinoma (BRAFm-ATC) Open
Background Although the FDA approved BRAF/MEK inhibitor combination DT has revolutionized the treatment of BRAFm-ATC, most patients eventually acquire resistance and progress. Given high immunogenicity and PD-L1 expression, immune checkpoi…
View article: A Meta-analysis of Surgical Outcomes of T4a and Infranotch T4b Oral Cancers
A Meta-analysis of Surgical Outcomes of T4a and Infranotch T4b Oral Cancers Open