Marko Baloh
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View article: HiBC: a publicly available collection of bacterial strains isolated from the human gut
HiBC: a publicly available collection of bacterial strains isolated from the human gut Open
View article: The small acid-soluble proteins of Clostridioides difficile regulate sporulation in a SpoIVB2-dependent manner
The small acid-soluble proteins of Clostridioides difficile regulate sporulation in a SpoIVB2-dependent manner Open
Clostridioides difficile is a pathogen whose transmission relies on the formation of dormant endospores. Spores are highly resilient forms of bacteria that resist environmental and chemical insults. In recent work, we found that C . diffic…
View article: Broad diversity of human gut bacteria accessible via a traceable strain deposition system
Broad diversity of human gut bacteria accessible via a traceable strain deposition system Open
Numerous bacteria in the human gut microbiome remain unknown and/or have yet to be cultured. While collections of human gut bacteria have been published, few strains have been made publicly available. A major hurdle in making strains publi…
View article: The small acid-soluble proteins of<i>Clostridioides difficile</i>regulate sporulation in a SpoIVB2-dependent manner
The small acid-soluble proteins of<i>Clostridioides difficile</i>regulate sporulation in a SpoIVB2-dependent manner Open
Clostridioides difficile is a pathogen whose transmission relies on the formation of dormant endospores. Spores are highly resilient forms of bacteria that resist environmental and chemical insults. In recent work, we found that C. diffici…
View article: Imaging Clostridioides difficile Spore Germination and Germination Proteins
Imaging Clostridioides difficile Spore Germination and Germination Proteins Open
Germination by C. difficile spores is the first step in the establishment of potentially life-threatening C. difficile infection (CDI). A deeper understanding of the mechanism by which spores germinate may provide insight for how to either…
View article: Imaging <i>Clostridioides difficile</i> spore germination and germination proteins
Imaging <i>Clostridioides difficile</i> spore germination and germination proteins Open
Clostridioides difficile spores are the infective form for this endospore-forming organism. The vegetative cells are intolerant to oxygen and poor competitors with a healthy gut microbiota. Therefore, in order for C. difficile to establish…
View article: Correction to: Protease-stable DARPins as promising oral therapeutics
Correction to: Protease-stable DARPins as promising oral therapeutics Open
View article: Clostridioides difficile spore germination: initiation to DPA release
Clostridioides difficile spore germination: initiation to DPA release Open
View article: Clostridioides difficile SpoVAD and SpoVAE Interact and Are Required for Dipicolinic Acid Uptake into Spores
Clostridioides difficile SpoVAD and SpoVAE Interact and Are Required for Dipicolinic Acid Uptake into Spores Open
C. difficile spore heat resistance provides an avenue for it to survive the disinfection protocols in hospital and community settings. The spore heat resistance is mainly the consequence of the high DPA content within the spore core.
View article: <i>Clostridioides difficile</i> SpoVAD and SpoVAE interact and are required for DPA packaging into spores
<i>Clostridioides difficile</i> SpoVAD and SpoVAE interact and are required for DPA packaging into spores Open
Clostridioides difficile spores, like the spores from most endospore-forming organisms, are a metabolically dormant stage of development with a complex structure that conveys considerable resistance to environmental conditions, e.g. , dry …
View article: Protease-stable DARPins as promising oral therapeutics
Protease-stable DARPins as promising oral therapeutics Open
Clostridioides difficile is an enteric bacterium whose exotoxins, TcdA and TcdB, inactivate small GTPases within the host cells, leading to bloody diarrhea. In prior work, our group engineered a panel of potent TcdB-neutralizing designed a…