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View article: Total Synthesis of (+)-Penicyclone A and Evaluation of Biological Activity Including Intermediate Compounds
Total Synthesis of (+)-Penicyclone A and Evaluation of Biological Activity Including Intermediate Compounds Open
Penicyclone A is a polyketide compound with a unique and intriguing structure recently isolated from the fungus Penicillium sp. F23-2 during an OSMAC (one-strain-many-compounds) campaign. The compound demonstrated significant antimicrobial…
View article: Rapid and Green Anion-Assisted Mechanochemical Peptide Cyclization
Rapid and Green Anion-Assisted Mechanochemical Peptide Cyclization Open
A novel mechanochemical approach is described for chloride-templated head-to-tail macrocyclization of a pentapeptide and a hexapeptide. This straightforward method allows the solvent-free preparation of cyclopeptides with yields comparable…
View article: Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia
Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia Open
Ghrelin and ghrelin receptor are expressed in colorectal adenoma and adjacent tissue with ghrelin expression being more pronounced in high grade dysplasia as a possible consequence of increased local synthesis.
View article: New Drugs on the Block—Emerging Treatments for Nonalcoholic Steatohepatitis
New Drugs on the Block—Emerging Treatments for Nonalcoholic Steatohepatitis Open
Patients with nonalcoholic steatohepatitis (NASH) are at higher risk of progression to advanced stages of fibrosis, cirrhosis, hepatocellular carcinoma and other end-stage liver disease complications. When addressing treatment of NASH, we …
View article: Hepatitis C Virus (HCV) Treatment in Croatia: Recent Advances and Ongoing Obstacles
Hepatitis C Virus (HCV) Treatment in Croatia: Recent Advances and Ongoing Obstacles Open
The prevalence of hepatitis C virus (HCV) antibodies in Croatia is low in the general population (reported <1%), similar to the prevalence rates of many European countries, but is higher in the populations at risk, especially among intrave…
View article: CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential
CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential Open
CX43 expression in mucosa surrounding adenoma could be an additional factor indicative of malignant potential. CX43 expression in colonic adenoma seems to be closely related to family history of colorectal cancer, statin therapy and hemogl…
View article: Hepatitis C Virus, Insulin Resistance, and Steatosis
Hepatitis C Virus, Insulin Resistance, and Steatosis Open
Hepatitis C virus (HCV) is one of the main causes of liver disease worldwide. Liver steatosis is a common finding in many hepatic and extrahepatic disorders, the most common being metabolic syndrome (MS). Over time, it has been shown that …
View article: The relationship between insulin resistance and colon cancer
The relationship between insulin resistance and colon cancer Open
Obesity and colon carcinoma are a growing health problem with colon carcinoma being the most common cancer of the alimentary tract. Risk factors for colon carcinoma, which are mediated by insulin resistance, include the so-called Western d…