Marko Repic
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View article: Engineered Tissue Tregs ameliorate inflammatory and ischemic diseases 3661
Engineered Tissue Tregs ameliorate inflammatory and ischemic diseases 3661 Open
Description Regulatory T cells (Tregs) play a central role in establishing immune tolerance, with a subset of these cells, dubbed Tissue Tregs, orchestrating specialized function including tissue repair, making them an ideal candidate for …
View article: SUN-556 GNTI-122: A Potentially Curative Engineered Treg Cell Therapy for the Treatment of Recently Diagnosed Type 1 Diabetes
SUN-556 GNTI-122: A Potentially Curative Engineered Treg Cell Therapy for the Treatment of Recently Diagnosed Type 1 Diabetes Open
Disclosure: M. Gose: None. P. Sharma: None. A. Meiners: None. K. Hawkins: None. S. Albertson: None. S. Hussel: None. S. Yang: None. L. Webb: None. P. Saikumar-Lakshmi: None. G. Uenishi: None. M. Repic: None. J. Buckner: None. C. Patel: Non…
View article: GNTI-122: an autologous antigen-specific engineered Treg cell therapy for type 1 diabetes
GNTI-122: an autologous antigen-specific engineered Treg cell therapy for type 1 diabetes Open
Tregs have the potential to establish long-term immune tolerance in patients recently diagnosed with type 1 diabetes (T1D) by preserving β cell function. Adoptive transfer of autologous thymic Tregs, although safe, exhibited limited effica…
View article: Efficacy and Safety of FX201, a Novel Intra-Articular IL-1Ra Gene Therapy for Osteoarthritis Treatment, in a Rat Model
Efficacy and Safety of FX201, a Novel Intra-Articular IL-1Ra Gene Therapy for Osteoarthritis Treatment, in a Rat Model Open
Osteoarthritis (OA) is a disabling, degenerative disease characterized by progressive cartilage and bone damage. There remains a need for local therapies that, following a single injection, can provide long-term pain relief and functional …
View article: Fab antibody fragment-functionalized liposomes for specific targeting of antigen-positive cells
Fab antibody fragment-functionalized liposomes for specific targeting of antigen-positive cells Open
Liposomes functionalized with monoclonal antibodies or their antigen-binding fragments have attracted much attention as specific drug delivery devices for treatment of various diseases including cancer. The conjugation of antibodies to lip…