Markus Bosmann
YOU?
Author Swipe
View article: Synergistic function of C5aR1 and C5aR2 complement receptors in defending against bacterial pneumonia 4441
Synergistic function of C5aR1 and C5aR2 complement receptors in defending against bacterial pneumonia 4441 Open
Description Streptococcus pneumoniae (Spn) is the leading cause of pneumonia-associated mortality in adults. Complement activation is critical for encapsulated Spn clearance but also augments ARDS pathogenesis. C5a binding to its two recep…
View article: Interleukin-27 orchestrates lymphocyte responses and disease severity during Legionella infection in the lung 2083
Interleukin-27 orchestrates lymphocyte responses and disease severity during Legionella infection in the lung 2083 Open
Description Legionnaires’ disease (LD) is a severe respiratory illness caused by Legionella spp., with a 7-10% fatality rate in the US and limited knowledge of its pathobiology. Interleukin (IL)-27 is an immunomodulatory cytokine that sign…
View article: Bacterial polyphosphates impede the macrophage response to infection 2084
Bacterial polyphosphates impede the macrophage response to infection 2084 Open
Description Sepsis affects ∼50 million people annually, with mortality rates of 20–50%. Host-pathogen interactions are implicated in its etiology but are understudied. Bacterial polyphosphates are metabolites with pleiotropic functions in …
View article: Transcriptomic responses of lung mesenchymal cells during pneumonia
Transcriptomic responses of lung mesenchymal cells during pneumonia Open
The role of mesenchymal cells during respiratory infection is not well defined, including whether, which, and how the different types of mesenchymal cells respond. We collected all mesenchymal cells from lung single-cell suspensions of mic…
View article: Tryptophan metabolism reprogramming contributes to the prothrombotic milieu in mice and humans infected with SARS-CoV-2
Tryptophan metabolism reprogramming contributes to the prothrombotic milieu in mice and humans infected with SARS-CoV-2 Open
SARS-CoV-2 infection disturbs the coagulation balance in the blood, triggering thrombosis and contributing to organ failure. The role of prothrombotic metabolites in COVID-19-associated coagulopathy remains elusive. Leveraging K18-hACE2 mi…
View article: Disruption of the C5a/C5aR1 axis confers protection against hookworm infection in lung
Disruption of the C5a/C5aR1 axis confers protection against hookworm infection in lung Open
Hookworms are soil-transmitted parasitic nematodes that penetrate the host skin before migrating to the lungs. With an estimated 500-700 million people infected worldwide, hookworm infections are a neglected tropical disease and a signific…
View article: The complement system: A key player in the host response to infections
The complement system: A key player in the host response to infections Open
Infections are one of the most significant healthcare and economic burdens across the world as underscored by the recent coronavirus pandemic. Moreover, with the increasing incidence of antimicrobial resistance, there is an urgent need to …
View article: Myeloid cell-derived interleukin-6 induces vascular dysfunction and vascular and systemic inflammation
Myeloid cell-derived interleukin-6 induces vascular dysfunction and vascular and systemic inflammation Open
Aims The cytokine interleukin-6 (IL-6) plays a central role in the inflammation cascade as well as cardiovascular disease progression. Since myeloid cells are a primary source of IL-6 formation, we aimed to generate a mouse model to study …
View article: Aging is associated with an insufficient early inflammatory response of lung endothelial cells in SARS-CoV-2 infection
Aging is associated with an insufficient early inflammatory response of lung endothelial cells in SARS-CoV-2 infection Open
Advanced age is associated with an increased susceptibility to Coronavirus Disease (COVID)-19 and more severe outcomes, although the underlying mechanisms are understudied. The lung endothelium is located next to infected epithelial cells …
View article: Nucleic acid sensing promotes inflammatory monocyte migration through biased coagulation factor VIIa signaling
Nucleic acid sensing promotes inflammatory monocyte migration through biased coagulation factor VIIa signaling Open
Protease activated receptors (PARs) are cleaved by coagulation proteases and thereby connect hemostasis with innate immune responses. Signaling of the tissue factor (TF) complex with factor VIIa (FVIIa) via PAR2 stimulates extracellular si…
View article: Sterility testing of germ-free mouse colonies
Sterility testing of germ-free mouse colonies Open
In biomedical research, germ-free and gnotobiotic mouse models enable the mechanistic investigation of microbiota-host interactions and their role on (patho)physiology. Throughout any gnotobiotic experiment, standardized and periodic micro…
View article: OC 22.1 Proteome and Phosphoproteome Analyses of SARS-CoV-2 Infected Humanized ACE2 Mice Platelets Revealed Reprogramming of Platelets from Early Hyperreactive to Late Antiviral Phenotypes
OC 22.1 Proteome and Phosphoproteome Analyses of SARS-CoV-2 Infected Humanized ACE2 Mice Platelets Revealed Reprogramming of Platelets from Early Hyperreactive to Late Antiviral Phenotypes Open
Background: COVID-19-associated coagulopathy (CAC), involving complex interactions between a hyperactive immune response, vascular endothelial cell dysfunction, and a state of hypercoagulability, is associated with thrombosis and death.SAR…
View article: Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27
Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27 Open
Externalized histones erupt from the nucleus as extracellular traps, are associated with several acute and chronic lung disorders, but their implications in the molecular pathogenesis of interstitial lung disease are incompletely defined. …
View article: HTRS2023.O8B.2 Proteome and phosphoproteome analyses of SARS-CoV-2 infected humanized ACE2 mice platelets reveal early hyperactive and late antiviral phenotypes
HTRS2023.O8B.2 Proteome and phosphoproteome analyses of SARS-CoV-2 infected humanized ACE2 mice platelets reveal early hyperactive and late antiviral phenotypes Open
Objectives: Here we evaluated the in vivo effect of HIF-1 in MPN thrombosis.Methods: JAK2V617F transgenic mice on a C57BL/6J background [8] were pre-treated with varying doses of the HIF-1 inhibitor echinomycin or DMSO by intraperitoneal i…
View article: Investigating the Role of Bacterial Long-Chain Polyphosphates in Macrophages during <i>Legionella pneumophila</i> Infection
Investigating the Role of Bacterial Long-Chain Polyphosphates in Macrophages during <i>Legionella pneumophila</i> Infection Open
Up to 10% of community-acquired pneumonia cases are identified as Legionnaires’ Disease, caused by the pathogen Legionella pneumophila. L. pneumophila naturally resides in freshwater systems and becomes pathogenic when man-made plumbing sy…
View article: Supplementary Figures from Pro- and Antitumorigenic Capacity of Immunoproteasomes in Shaping the Tumor Microenvironment
Supplementary Figures from Pro- and Antitumorigenic Capacity of Immunoproteasomes in Shaping the Tumor Microenvironment Open
Supplementary Figures 1-9
View article: Data from Pro- and Antitumorigenic Capacity of Immunoproteasomes in Shaping the Tumor Microenvironment
Data from Pro- and Antitumorigenic Capacity of Immunoproteasomes in Shaping the Tumor Microenvironment Open
Apart from the constitutive proteasome, the immunoproteasome that comprises the three proteolytic subunits LMP2, MECL-1, and LMP7 is expressed in most immune cells. In this study, we describe opposing roles for immunoproteasomes in regulat…
View article: Supplementary Figures from Pro- and Antitumorigenic Capacity of Immunoproteasomes in Shaping the Tumor Microenvironment
Supplementary Figures from Pro- and Antitumorigenic Capacity of Immunoproteasomes in Shaping the Tumor Microenvironment Open
Supplementary Figures 1-9
View article: Data from Pro- and Antitumorigenic Capacity of Immunoproteasomes in Shaping the Tumor Microenvironment
Data from Pro- and Antitumorigenic Capacity of Immunoproteasomes in Shaping the Tumor Microenvironment Open
Apart from the constitutive proteasome, the immunoproteasome that comprises the three proteolytic subunits LMP2, MECL-1, and LMP7 is expressed in most immune cells. In this study, we describe opposing roles for immunoproteasomes in regulat…
View article: Immunomodulation of neutrophil granulocyte functions by bacterial polyphosphates
Immunomodulation of neutrophil granulocyte functions by bacterial polyphosphates Open
Polyphosphates are highly conserved, linear polymers of monophosphates that reside in all living cells. Bacteria produce long chains containing hundreds to thousands of phosphate units, which can interfere with host defense to infection. H…
View article: Immunomodulation of Neutrophil Granulocyte Functions by Bacterial Polyphosphates
Immunomodulation of Neutrophil Granulocyte Functions by Bacterial Polyphosphates Open
Polyphosphates are highly conserved, linear polymers of monophosphates that reside in all living cells. Bacteria produce long chains containing hundreds to thousands of phosphate units, which can interfere with host defense to infection. H…
View article: Bacterial polyphosphates induce CXCL4 and synergize with complement anaphylatoxin C5a in lung injury
Bacterial polyphosphates induce CXCL4 and synergize with complement anaphylatoxin C5a in lung injury Open
Polyphosphates are linear polymers of inorganic phosphates that exist in all living cells and serve pleiotropic functions. Bacteria produce long-chain polyphosphates, which can interfere with host defense to infection. In contrast, short-c…
View article: Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron
Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron Open
The recently identified, globally predominant SARS-CoV-2 Omicron variant (BA.1) is highly transmissible, even in fully vaccinated individuals, and causes attenuated disease compared with other major viral variants recognized to date 1–7 . …
View article: Bacterial-Type Long-Chain Polyphosphates Bind Human Proteins in the Phosphatidylinositol Signaling Pathway
Bacterial-Type Long-Chain Polyphosphates Bind Human Proteins in the Phosphatidylinositol Signaling Pathway Open
[Image: see text] A human proteome microarray was probed with long-chain polyphosphates. Several of the identified proteins (DAB1, PIP4K2B) were further validated using small-scale assays. The depicted proteins shared the common feature of…