Markus Bredel
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View article: EXTH-98. BRI3 Promotes Glioblastoma Progression and Radiation Resistance via GPX8-Driven Redox Homeostasis
EXTH-98. BRI3 Promotes Glioblastoma Progression and Radiation Resistance via GPX8-Driven Redox Homeostasis Open
BACKGROUND We previously identified Brain Protein I3 (BRI3) gene dosage gain as a robust prognostic biomarker in IDH-wildtype glioblastoma (GBM). However, the mechanism by which BRI3 contributes to radiation resistance and tumor progressio…
View article: Preoperative Stereotactic Radiosurgery for Brain Metastases: A Phase 1 Dose Escalation Study Demonstrating Reduced Leptomeningeal Disease
Preoperative Stereotactic Radiosurgery for Brain Metastases: A Phase 1 Dose Escalation Study Demonstrating Reduced Leptomeningeal Disease Open
Preoperative SRS to 15 Gy is safe for tumors 2 to 6 cm and significantly reduces nLMD without compromising local control or OS. These findings support preoperative SRS as a viable treatment strategy and justify further investigation into o…
View article: CBCT-Guided Online Adaptive Radiation Therapy for Accelerated Partial Breast Irradiation: A Single-Institution Experience
CBCT-Guided Online Adaptive Radiation Therapy for Accelerated Partial Breast Irradiation: A Single-Institution Experience Open
This study, the largest APBI with OART cohort to date, demonstrates excellent cosmesis, minimal toxicity, and promising early oncologic outcomes for ESBC patients.
View article: Frameless Linac-based Radiosurgery for Benign Intracranial Tumors Treated with HyperArc: Analysis of Tumor Control and Toxicity
Frameless Linac-based Radiosurgery for Benign Intracranial Tumors Treated with HyperArc: Analysis of Tumor Control and Toxicity Open
Purpose: HyperArc™ (HA) automates both planning and delivery of single-isocenter VMAT radiosurgery (SRS) and was designed for complex multi-metastasis cases. The clinical effectiveness of treating benign intracranial tumors (BIT) with HA i…
View article: Diagnosing GBM Progression with and Without AI-Measured Longitudinal Volume Measurements: A Retrospective Observational Study
Diagnosing GBM Progression with and Without AI-Measured Longitudinal Volume Measurements: A Retrospective Observational Study Open
Glioblastomas (GBM) grow rapidly and infiltrate the cerebral parenchyma, leading to significant neurological morbidity and mortality. Early detection of tumor growth promotes early therapeutic interventions that delay neurological progress…
View article: Diagnosing Growth in Low-Grade Gliomas with and Without AI-Measured Longitudinal Volume Measurements: A Retrospective Observational Study
Diagnosing Growth in Low-Grade Gliomas with and Without AI-Measured Longitudinal Volume Measurements: A Retrospective Observational Study Open
Low-grade gliomas (LGG) invade the brains of young and productive adults leading to significant neurological morbid-ity. Mutations in the isocitrate dehydrogenase (IDH) gene are very common in LGG. Because IDH1 inhibitors are ef-fective in…
View article: Understanding the Effect of Prescription Isodose in Single-Fraction Stereotactic Radiosurgery on Plan Quality and Clinical Outcomes for Solid Brain Metastases
Understanding the Effect of Prescription Isodose in Single-Fraction Stereotactic Radiosurgery on Plan Quality and Clinical Outcomes for Solid Brain Metastases Open
BACKGROUND AND OBJECTIVES: There is wide variation in treatment planning strategy for central nervous system (CNS) stereotactic radiosurgery. We sought to understand what relationships exist between intratumor maximum dose and local contro…
View article: Data from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression
Data from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression Open
Glioblastoma (GBM) comprises distinct subtypes characterized by their molecular profile. Mesenchymal identity in GBM has been associated with a comparatively unfavorable prognosis, primarily due to inherent resistance of these tumors to cu…
View article: Supplementary Information from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression
Supplementary Information from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression Open
Supplementary Figure legends and tables.
View article: Supplementary Figure 4 from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression
Supplementary Figure 4 from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression Open
Proliferation, migration and invasion assays in SNB19 cells.
View article: Supplementary Figure 7 from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression
Supplementary Figure 7 from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression Open
ZBTB18 promoter methylation analysis.
View article: Supplementary Figure 4 from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression
Supplementary Figure 4 from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression Open
Proliferation, migration and invasion assays in SNB19 cells.
View article: Data from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression
Data from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression Open
Glioblastoma (GBM) comprises distinct subtypes characterized by their molecular profile. Mesenchymal identity in GBM has been associated with a comparatively unfavorable prognosis, primarily due to inherent resistance of these tumors to cu…
View article: Supplementary Figure 5 from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression
Supplementary Figure 5 from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression Open
Proliferation, migration and invasion assays in BTSC233 and JX6 cells.
View article: Supplementary Figure 3 from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression
Supplementary Figure 3 from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression Open
GSEA analysis in JX6.
View article: Supplementary Figure 2 from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression
Supplementary Figure 2 from Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression Open
GSEA analysis in BTSC233.
View article: Supplementary Figure 7 from Targeting Protein Kinase CK2 Suppresses Prosurvival Signaling Pathways and Growth of Glioblastoma
Supplementary Figure 7 from Targeting Protein Kinase CK2 Suppresses Prosurvival Signaling Pathways and Growth of Glioblastoma Open
PDF file - 55K, Supplemental Figure 7. CX-4945 Abrogates GBM Cell Survival.
View article: Supplementary Figure 5 from Targeting Protein Kinase CK2 Suppresses Prosurvival Signaling Pathways and Growth of Glioblastoma
Supplementary Figure 5 from Targeting Protein Kinase CK2 Suppresses Prosurvival Signaling Pathways and Growth of Glioblastoma Open
PDF file - 60K, Supplemental Figure 5. Effect of CX-4945 on Survival of GBM Xenograft Cells.
View article: CCR Translation for This Article from Targeting Protein Kinase CK2 Suppresses Prosurvival Signaling Pathways and Growth of Glioblastoma
CCR Translation for This Article from Targeting Protein Kinase CK2 Suppresses Prosurvival Signaling Pathways and Growth of Glioblastoma Open
CCR Translation for This Article from Targeting Protein Kinase CK2 Suppresses Prosurvival Signaling Pathways and Growth of Glioblastoma
View article: SFigure 7 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival
SFigure 7 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival Open
Figure S7 shows bevacizumab is transcytosed across normal brain ECs and TECs.
View article: SFigure 3 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival
SFigure 3 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival Open
Figure S3 shows co-localization of different fractions of bevacizumab or human IgG (hIgG) with Rab4 or LAMP1 in CD133+ GBM cells in vitro, and of rat anti-mouse VEGF-A IgG in an established tumor in the immune competent mouse model of GBM …
View article: SFigure 3 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival
SFigure 3 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival Open
Figure S3 shows co-localization of different fractions of bevacizumab or human IgG (hIgG) with Rab4 or LAMP1 in CD133+ GBM cells in vitro, and of rat anti-mouse VEGF-A IgG in an established tumor in the immune competent mouse model of GBM …
View article: Supplementary Figure 2 from Targeting Protein Kinase CK2 Suppresses Prosurvival Signaling Pathways and Growth of Glioblastoma
Supplementary Figure 2 from Targeting Protein Kinase CK2 Suppresses Prosurvival Signaling Pathways and Growth of Glioblastoma Open
PDF file - 69K, Supplemental Figure 2. Inhibition of CK2 Suppresses IL-6-induced STAT-3 Activation in GBM Cells.