Markus C. Fleisch
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View article: Evaluation of Baseline Characteristics and Therapeutic Management Strategies in Metastatic Cervical Cancer in Germany: A Multicentric Retrospective Longitudinal Observational Study
Evaluation of Baseline Characteristics and Therapeutic Management Strategies in Metastatic Cervical Cancer in Germany: A Multicentric Retrospective Longitudinal Observational Study Open
Real-world data on treatment patterns and outcomes in recurrent or metastatic cervical cancer (r/mCC) are lacking. This first national quality assurance initiative was a retrospective analysis of patients with r/mCC diagnosed between 2018 …
View article: Surgical training in gynecological oncology using soft-embalmed human cadavers: first pilot study
Surgical training in gynecological oncology using soft-embalmed human cadavers: first pilot study Open
View article: Endometrial Cancer. Guideline of the DGGG, DKG and DKH (S3-Level, AWMF Registry Number 032/034-OL, September 2022). Part 1 with Recommendations on the Epidemiology, Screening, Diagnosis and Hereditary Factors of Endometrial Cancer, Geriatric Assessment and Supply Structures
Endometrial Cancer. Guideline of the DGGG, DKG and DKH (S3-Level, AWMF Registry Number 032/034-OL, September 2022). Part 1 with Recommendations on the Epidemiology, Screening, Diagnosis and Hereditary Factors of Endometrial Cancer, Geriatric Assessment and Supply Structures Open
Summary The S3-guideline on endometrial cancer, first published in April 2018, was reviewed in its entirety between April 2020 and January 2022 and updated. The review was carried out at the request of German Cancer Aid as part of the Onco…
View article: Endometrial Cancer. Guideline of the DGGG, DKG and DKH (S3-Level, AWMF Registry Number 032/034-OL, September 2022) – Part 2 with Recommendations on the Therapy of Precancerous Lesions and Early-stage Endometrial Cancer, Surgical Therapy, Radiotherapy and Drug-based Therapy, Follow-up Care, Recurrence and Metastases, Psycho-oncological Care, Palliative Care, Patient Education, and Rehabilitative and Physiotherapeutic Care
Endometrial Cancer. Guideline of the DGGG, DKG and DKH (S3-Level, AWMF Registry Number 032/034-OL, September 2022) – Part 2 with Recommendations on the Therapy of Precancerous Lesions and Early-stage Endometrial Cancer, Surgical Therapy, Radiotherapy and Drug-based Therapy, Follow-up Care, Recurrence and Metastases, Psycho-oncological Care, Palliative Care, Patient Education, and Rehabilitative and Physiotherapeutic Care Open
Summary The S3-guideline on endometrial cancer, first published in April 2018, was reviewed in its entirety between April 2020 and January 2022 and updated. The review was carried out at the request of German Cancer Aid as part of the Onco…
View article: Supplementary Figure 1 from Targeted and Nontargeted Effects of Ionizing Radiation That Impact Genomic Instability
Supplementary Figure 1 from Targeted and Nontargeted Effects of Ionizing Radiation That Impact Genomic Instability Open
Supplementary Figure 1 from Targeted and Nontargeted Effects of Ionizing Radiation That Impact Genomic Instability
View article: Supplementary Figure 1 from Targeted and Nontargeted Effects of Ionizing Radiation That Impact Genomic Instability
Supplementary Figure 1 from Targeted and Nontargeted Effects of Ionizing Radiation That Impact Genomic Instability Open
Supplementary Figure 1 from Targeted and Nontargeted Effects of Ionizing Radiation That Impact Genomic Instability
View article: Data from Targeted and Nontargeted Effects of Ionizing Radiation That Impact Genomic Instability
Data from Targeted and Nontargeted Effects of Ionizing Radiation That Impact Genomic Instability Open
Radiation-induced genomic instability, in which the progeny of irradiated cells display a high frequency of nonclonal genomic damage, occurs at a frequency inconsistent with mutation. We investigated the mechanism of this nontargeted effec…
View article: Data from Targeted and Nontargeted Effects of Ionizing Radiation That Impact Genomic Instability
Data from Targeted and Nontargeted Effects of Ionizing Radiation That Impact Genomic Instability Open
Radiation-induced genomic instability, in which the progeny of irradiated cells display a high frequency of nonclonal genomic damage, occurs at a frequency inconsistent with mutation. We investigated the mechanism of this nontargeted effec…
View article: Operative Therapie des Endometriumkarzinoms
Operative Therapie des Endometriumkarzinoms Open
Im Juli 2022 ist mit der Version 2.0 das erste Update der deutschen interdisziplinären S3-Leitlinie für die Diagnostik, Therapie und Nachsorge der Patientinnen mit Endometriumkarzinom, gefördert durch das Leitlinienprogramm Onkologie ersch…
View article: Factors Indicating Surgical Excision in Classical Type of Lobular Neoplasia of the Breast
Factors Indicating Surgical Excision in Classical Type of Lobular Neoplasia of the Breast Open
Purpose: Classical type of lobular neoplasia (LN) encompassing both atypical lobular hyperplasia and classical lobular carcinoma in situ of the breast is a lesion with uncertain malignant potential and has been the topic of s…
View article: The Prevention of Positioning Injuries During Gynecologic Surgery. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry Number 015/077, October 2020)
The Prevention of Positioning Injuries During Gynecologic Surgery. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry Number 015/077, October 2020) Open
Purpose Positioning injuries are relatively common, forensically highly relevant complications of gynecologic surgery. The aim of this official AWMF S2k-guideline is to provide statements and recommendations on how to prevent positioning i…
View article: Use of music during vaginal birth and caesarean section: an interprofessional survey
Use of music during vaginal birth and caesarean section: an interprofessional survey Open
View article: Breast-conserving surgery with intraoperative radiotherapy in recurrent breast cancer: the patient’s perspective
Breast-conserving surgery with intraoperative radiotherapy in recurrent breast cancer: the patient’s perspective Open
View article: Clinical Imaging of the Heterogeneous Group of Triple-negative Breast Cancer
Clinical Imaging of the Heterogeneous Group of Triple-negative Breast Cancer Open
The histopathological subtype of TNBC influences its presentation in ultrasound and mammogram. This can reflect a different growth pattern of the subtypes and may have an impact on the early diagnosis of TNBC.
View article: Structural Insight into IAPP‐Derived Amyloid Inhibitors and Their Mechanism of Action
Structural Insight into IAPP‐Derived Amyloid Inhibitors and Their Mechanism of Action Open
Designed peptides derived from the islet amyloid polypeptide (IAPP) cross‐amyloid interaction surface with Aβ (termed interaction surface mimics or ISMs) have been shown to be highly potent inhibitors of Aβ amyloid self‐assembly. However, …
View article: Structural Insight into IAPP‐Derived Amyloid Inhibitors and Their Mechanism of Action
Structural Insight into IAPP‐Derived Amyloid Inhibitors and Their Mechanism of Action Open
Designed peptides derived from the islet amyloid polypeptide (IAPP) cross‐amyloid interaction surface with Aβ (termed interaction surface mimics or ISMs) have been shown to be highly potent inhibitors of Aβ amyloid self‐assembly. However, …
View article: Prognostic impact of PIK3CA protein expression in triple negative breast cancer and its subtypes
Prognostic impact of PIK3CA protein expression in triple negative breast cancer and its subtypes Open
View article: Effects of music intervention during caesarean delivery on anxiety and stress of the mother a controlled, randomised study
Effects of music intervention during caesarean delivery on anxiety and stress of the mother a controlled, randomised study Open
German registry for clinical trials ( DRKS00007840 ). Registered 16/06/2015. Retrospectively registered.
View article: Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Number 032/034-OL, April 2018) – Part 2 with Recommendations on the Therapy and Follow-up of Endometrial Cancer, Palliative Care, Psycho-oncological/Psychosocial Care/Rehabilitation/Patient Information and Healthcare Facilities
Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Number 032/034-OL, April 2018) – Part 2 with Recommendations on the Therapy and Follow-up of Endometrial Cancer, Palliative Care, Psycho-oncological/Psychosocial Care/Rehabilitation/Patient Information and Healthcare Facilities Open
Summary The first German interdisciplinary S3-guideline on the diagnosis, therapy and follow-up of patients with endometrial cancer was published in April 2018. Funded by German Cancer Aid as part of an Oncology Guidelines Program, the lea…
View article: Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Nummer 032/034-OL, April 2018) – Part 1 with Recommendations on the Epidemiology, Screening, Diagnosis and Hereditary Factors of Endometrial Cancer
Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Nummer 032/034-OL, April 2018) – Part 1 with Recommendations on the Epidemiology, Screening, Diagnosis and Hereditary Factors of Endometrial Cancer Open
Summary The first German interdisciplinary S3-guideline on the diagnosis, therapy and follow-up of patients with endometrial cancer was published in April 2018. Funded by German Cancer Aid as part of an Oncology Guidelines Program, the lea…
View article: Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate
Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate Open
Membrane-assisted amyloid formation is implicated in human diseases, and many of the aggregating species accelerate amyloid formation and induce cell death. While structures of membrane-associated intermediates would provide tremendous ins…
View article: Author response: Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate
Author response: Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Membrane-assisted amyloid formation is implicated in human d…
View article: BRCA1 controls the cell division axis and governs ploidy and phenotype in human mammary cells
BRCA1 controls the cell division axis and governs ploidy and phenotype in human mammary cells Open
BRCA1 deficiency may perturb the differentiation hierarchy present in the normal mammary gland and is associated with the genesis of breast cancers that are genomically unstable and typically display a basal-like transcriptome. Oriented ce…
View article: The International Endometriosis Evaluation Program (IEEP Study) – A Systematic Study for Physicians, Researchers and Patients
The International Endometriosis Evaluation Program (IEEP Study) – A Systematic Study for Physicians, Researchers and Patients Open
The documentation system permits the history and clinical data of patients with endometriosis to be recorded. The IEEP combines this information with biomaterials and uses it for scientific studies. The recorded data can also be used to ev…
View article: Predictors of Impaired Postpartum Renal Function in Women after Preeclampsia: Results of a Prospective Single Center Study
Predictors of Impaired Postpartum Renal Function in Women after Preeclampsia: Results of a Prospective Single Center Study Open
Objective . The purpose of this prospective study was to investigate the predictive value of single prepartum findings combined with serum biomarkers sFlt-1 (soluble fms-like tyrosine kinase-1) and PlGF (placental growth factor) indicating…
View article: Gestational Trophoblastic Disorders: An Update in 2015
Gestational Trophoblastic Disorders: An Update in 2015 Open
Gestational trophoblastic diseases (GTD) are a group of pregnancy-related disorders representing rare human tumours. They encompass premalignant disorders including complete (CHM), partial hydatidiform mole (PHM), exaggerated placental sit…