Markus Casper
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View article: Impact of Salpingotomy on Intrauterine Pregnancy and Recurrent Ectopic Pregnancy Rates: A Meta-Analysis
Impact of Salpingotomy on Intrauterine Pregnancy and Recurrent Ectopic Pregnancy Rates: A Meta-Analysis Open
Ectopic pregnancy poses significant risks to future fertility and recurrence, and can be surgically resolved if the traditional approach is ineffective. Salpingotomy has emerged as a preferred surgical option to treat ectopic pregnancy, as…
View article: Percutaneous endoscopic colostomy to relieve malignant bowel obstruction
Percutaneous endoscopic colostomy to relieve malignant bowel obstruction Open
Background: Malignant bowel obstruction due to peritoneal carcinomatosis is a common problem. When surgery is not feasible in the context of a high intraperitoneal tumour burden, other techniques are required. Case report: We report the ca…
View article: Retrospective study of the incidence, risk factors, treatment outcomes of bacterial infections at uncommon sites in cirrhotic patients
Retrospective study of the incidence, risk factors, treatment outcomes of bacterial infections at uncommon sites in cirrhotic patients Open
BACKGROUND Bacterial infections (BI) negatively affect the natural course of cirrhosis. The most frequent BI are urinary tract infections (UTI), pneumonia, and spontaneous-bacterial peritonitis (SBP). AIM To assess the relevance of bacteri…
View article: Altered profiles of circulating cytokines in chronic liver diseases (NAFLD/HCC): Impact of the PNPLA3 I148M risk allele
Altered profiles of circulating cytokines in chronic liver diseases (NAFLD/HCC): Impact of the PNPLA3 I148M risk allele Open
Background: Individuals carrying the risk variant p.I148M of patatin-like phospholipase domain-containing protein 3 ( PNPLA3 ) have a higher susceptibility to fatty liver diseases and associated complications, including HCC, a cancer close…
View article: Endoscopic Mucosal Resection of Non-pedunculated Colorectal Polyps ≥20mm: Outcome in a Self-taught Skills Environment
Endoscopic Mucosal Resection of Non-pedunculated Colorectal Polyps ≥20mm: Outcome in a Self-taught Skills Environment Open
Background and Aims: Endoscopic mucosal resection (EMR) of non-pedunculated colorectal polyps ≥20mm is technically demanding and should preferentially be performed by specialist endoscopists in referral centres. Little is known about the o…
View article: Artificial‐intelligence‐based decision support tools for the differential diagnosis of colitis
Artificial‐intelligence‐based decision support tools for the differential diagnosis of colitis Open
Background Whereas Artificial Intelligence (AI) based tools have recently been introduced in the field of gastroenterology, application in inflammatory bowel disease (IBD) is in its infancies. We established AI‐based algorithms to distingu…
View article: Comparison of immersive and non-immersive virtual reality videos as substitute for in-hospital teaching during coronavirus lockdown: a survey with graduate medical students in Germany
Comparison of immersive and non-immersive virtual reality videos as substitute for in-hospital teaching during coronavirus lockdown: a survey with graduate medical students in Germany Open
As a consequence of the continued Covid-19 lockdown in Germany, in-hospital teaching for medical students was impossible. While lectures and other theoretical training were relatively easily converted into online sessions using platforms s…
View article: Genetic variation in <i>TERT</i> modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study
Genetic variation in <i>TERT</i> modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study Open
Objective Hepatocellular carcinoma (HCC) often develops in patients with alcohol-related cirrhosis at an annual risk of up to 2.5%. Some host genetic risk factors have been identified but do not account for the majority of the variance in …
View article: Digital single-operator pancreatoscopy for the treatment of symptomatic pancreatic duct stones: a prospective multicenter cohort trial
Digital single-operator pancreatoscopy for the treatment of symptomatic pancreatic duct stones: a prospective multicenter cohort trial Open
Background Digital single-operator pancreatoscopy (DSOP)-guided lithotripsy is a novel treatment modality for pancreatic endotherapy, with demonstrated technical success in retrospective series of between 88 % and 100 %. The aim of this pr…
View article: The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis
The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis Open
The host genetic background for hepatocellular carcinoma (HCC) is incompletely understood. We aimed to determine if four germline genetic polymorphisms, rs429358 in apolipoprotein E ( APOE ), rs2642438 in mitochondrial amidoxime reducing c…
View article: Isolated bacterial infection without decompensation has no impact on survival of compensated patients with cirrhosis
Isolated bacterial infection without decompensation has no impact on survival of compensated patients with cirrhosis Open
Background & Aims Bacterial infections (BI) affect the natural course of cirrhosis and were suggested to be a landmark event marking the transition to the decompensated stage. Our specific aim was to evaluate the impact of BI on the natura…
View article: Supplementary Material for: <b><i>SEC62</i></b> and <b><i>SEC63</i></b> Expression in Hepatocellular Carcinoma and Tumor-Surrounding Liver Tissue
Supplementary Material for: <b><i>SEC62</i></b> and <b><i>SEC63</i></b> Expression in Hepatocellular Carcinoma and Tumor-Surrounding Liver Tissue Open
Introduction: The endoplasmic reticulum transmembrane proteins Sec61, Sec62, and Sec63 are responsible for the intracellular trafficking of precursor proteins and affect intracellular signaling. SEC62 overexpression has been linked to vari…
View article: <b><i>SEC62</i></b> and <b><i>SEC63</i></b> Expression in Hepatocellular Carcinoma and Tumor-Surrounding Liver Tissue
<b><i>SEC62</i></b> and <b><i>SEC63</i></b> Expression in Hepatocellular Carcinoma and Tumor-Surrounding Liver Tissue Open
Introduction: The endoplasmic reticulum transmembrane proteins Sec61, Sec62, and Sec63 are responsible for the intracellular trafficking of precursor proteins and affect intracellular signaling. SEC62 overexpression has been linked to vari…
View article: Pre-endoscopy SARS-CoV-2 testing strategy during COVID-19 pandemic: <i>The care must go on</i>
Pre-endoscopy SARS-CoV-2 testing strategy during COVID-19 pandemic: <i>The care must go on</i> Open
Background In response to the COVID-19 pandemic, endoscopic societies have recommended reduction of endoscopic procedures. In particular non-urgent endoscopies should be postponed. However, this might lead to unnecessary delay in diagnosin…
View article: Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers
Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers Open
Background and Aims Carriage of rs738409:G in patatin‐like phospholipase domain containing 3 ( PNPLA3 ) is associated with an increased risk for developing alcohol‐related cirrhosis and hepatocellular carcinoma (HCC). Recently, rs72613567:…
View article: The <i>ATG16L1</i> gene variant rs2241880 (p.T300A) is associated with susceptibility to HCC in patients with cirrhosis
The <i>ATG16L1</i> gene variant rs2241880 (p.T300A) is associated with susceptibility to HCC in patients with cirrhosis Open
Background and aims Protein and organelle turnover by autophagy is a key component to maintain cellular homeostasis. Loss of the autophagy protein ATG16L1 is associated with reduced bacterial killing and aberrant interleukin‐1β production,…
View article: Deep-learning based detection of gastric precancerous conditions
Deep-learning based detection of gastric precancerous conditions Open
Conventional white-light endoscopy has high interobserver variability for the diagnosis of gastric precancerous conditions.Here we present a deeplearning (DL) approach for the diagnosis of atrophic gastritis developed and trained using rea…
View article: Common NOD2 Risk Variants as Major Susceptibility Factors for Bacterial Infections in Compensated Cirrhosis
Common NOD2 Risk Variants as Major Susceptibility Factors for Bacterial Infections in Compensated Cirrhosis Open
OBJECTIVES: Common nucleotide-binding oligomerization domain containing 2 ( NOD 2) gene variants have been associated with bacterial infections (BIs) in cirrhosis, in particular, spontaneous bacterial peritonitis, and mortality. Our aim wa…
View article: Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis
Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis Open
Objective Homozygous alpha1-antitrypsin (AAT) deficiency increases the risk for developing cirrhosis, whereas the relevance of heterozygous carriage remains unclear. Hence, we evaluated the impact of the two most relevant AAT variants (‘Pi…
View article: Correction: Genetic Variants in PNPLA3 and TM6SF2 Predispose to the Development of Hepatocellular Carcinoma in Individuals With Alcohol-Related Cirrhosis
Correction: Genetic Variants in PNPLA3 and TM6SF2 Predispose to the Development of Hepatocellular Carcinoma in Individuals With Alcohol-Related Cirrhosis Open
Author Pierre Deltenre, MD should appear in the author list in position 25, between Felix Braun and Thomas Berg. He should also have a PhD degree added to his name.
View article: OWE-016 Genetic variants in PNPLA3 and TM6SF2 predispose to hepatocellular carcinoma in patients with alcohol-related cirrhosis
OWE-016 Genetic variants in PNPLA3 and TM6SF2 predispose to hepatocellular carcinoma in patients with alcohol-related cirrhosis Open
Introduction Variants in patatin-like phospholipase domain-containing 3 (PNPLA3; rs738409), transmembrane 6 superfamily member 2 (TM6SF2; rs58542926) and membrane bound O-acyltransferase domain containing 7 (MBOAT7; rs641738) are risk fact…