Markus Cornberg
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View article: Ten‐Year Follow‐Up After 96 Weeks Treatment With Peginterferon Plus Tenofovir in Hepatitis D (HIDIT‐II): Improved Clinical Outcome After Combination Therapy
Ten‐Year Follow‐Up After 96 Weeks Treatment With Peginterferon Plus Tenofovir in Hepatitis D (HIDIT‐II): Improved Clinical Outcome After Combination Therapy Open
Background Chronic delta hepatitis represents a major health burden. Until recently, pegylated interferon‐alfa‐2a (PEG‐IFNα) therapy was the only treatment option for patients infected with hepatitis D virus (HDV). The aim of this study wa…
View article: Treatment response to bulevirtide is linked to amelioration of portal hypertension in patients with chronic hepatitis D
Treatment response to bulevirtide is linked to amelioration of portal hypertension in patients with chronic hepatitis D Open
Background & Aims: Portal hypertension (PH) drives decompensation in patients with advanced chronic liver disease. Effects of antiviral treatment with bulevirtide (BLV) and achievement of suggested treatment endpoints on PH in patients wit…
View article: <scp>HBV</scp> Dominance Is Associated With a Distinct Inflammatory Milieu in <scp>HBV</scp> / <scp>HCV</scp> Coinfection
<span>HBV</span> Dominance Is Associated With a Distinct Inflammatory Milieu in <span>HBV</span> / <span>HCV</span> Coinfection Open
Hepatitis B (HBV) and C (HCV) virus coinfection is linked to a higher risk of cirrhosis and hepatocellular carcinoma (HCC) compared to monoinfection. Despite this, data are limited, and further investigation is needed to understand the und…
View article: Association Between Sustained Virological Response and Adverse Liver-related Events in Patients With Decompensated Hepatitis C Virus Cirrhosis
Association Between Sustained Virological Response and Adverse Liver-related Events in Patients With Decompensated Hepatitis C Virus Cirrhosis Open
SVR was associated with a reduced risk of LREs in patients with decompensated HCV cirrhosis with a MELD score <15, whereas no clinical benefit was observed in those with higher MELD scores despite an SVR-associated MELD decrease.
View article: Extrahepatic Replication and Genomic Signatures of the Hepatitis E Virus in the Kidney
Extrahepatic Replication and Genomic Signatures of the Hepatitis E Virus in the Kidney Open
Introduction The hepatitis E virus (HEV; species Paslahepevirus balayani ) is a common human pathogenic and zoonotic virus that can cause both acute fulminant and chronic hepatitis. Despite its reputation as a hepatotropic virus, HEV infec…
View article: Distinct inflammatory imprint in non-cirrhotic and cirrhotic patients before and after direct-acting antiviral therapy
Distinct inflammatory imprint in non-cirrhotic and cirrhotic patients before and after direct-acting antiviral therapy Open
Background/Aims: Hepatitis C virus (HCV) infection remains a global health challenge, leading to chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC). Despite the high efficacy of direct-acting antiviral therapy in achievin…
View article: Origin of Hypofunctional CD103 <sup>+</sup> NK Cells in Cirrhosis‐Associated Ascites
Origin of Hypofunctional CD103 <sup>+</sup> NK Cells in Cirrhosis‐Associated Ascites Open
The occurrence of ascites is a frequent complication associated with the decompensation of liver cirrhosis. While it is known that cirrhosis leads to altered immune responses in the periphery, the immunological milieu of ascites remains po…
View article: Droplet Digital PCR: A Powerful Tool for Accurate Quantification of Hepatitis D Virus RNA Levels and Verification of Detection Limits
Droplet Digital PCR: A Powerful Tool for Accurate Quantification of Hepatitis D Virus RNA Levels and Verification of Detection Limits Open
Reliable quantification of hepatitis D virus (HDV) RNA levels is necessary for initiating and guiding antiviral treatment. The aim of this work is to develop and validate a digital PCR method for the accurate quantification of HDV RNA, inc…
View article: Distinct clusters of bacterial and fungal microbiota in end-stage liver cirrhosis correlate with antibiotic treatment, intestinal barrier impairment, and systemic inflammation
Distinct clusters of bacterial and fungal microbiota in end-stage liver cirrhosis correlate with antibiotic treatment, intestinal barrier impairment, and systemic inflammation Open
Decompensated liver cirrhosis (dLC) is associated with intestinal dysbiosis, however, underlying reasons and clinical consequences remain largely unexplored. We investigated bacterial and fungal microbiota, their relation with gut barrier …
View article: Frequency, Severity and Impact of Pegylated Interferon Alpha–Associated Flares in Hepatitis D Infection
Frequency, Severity and Impact of Pegylated Interferon Alpha–Associated Flares in Hepatitis D Infection Open
We analysed the frequency, severity and impact of hepatitis flares in a large Phase 2 study investigating pegylated interferon‐alfa‐2a (PEG‐IFNa) for the treatment of hepatitis D. In the HIDIT‐II study, 120 patients were treated for 96 wee…
View article: Detection of<i>Paracoccus yeei</i>in Spontaneous Bacterial Peritonitis using Rapid, Long Read Sequencing
Detection of<i>Paracoccus yeei</i>in Spontaneous Bacterial Peritonitis using Rapid, Long Read Sequencing Open
Ascites is a common complication in patients with decompensated liver cirrhosis. Spontaneous bacterial peritonitis (SBP) is the most frequent infection, affecting up to 30% of hospitalized patients with ascites. Multidrug-resistant bacteri…
View article: P-2191. Efficacy and safety of buleviritide monotherapy for chronic hepatitis D in patients with and without cirrhosis: results from the week 144 interim analysis of a phase 3 randomized study
P-2191. Efficacy and safety of buleviritide monotherapy for chronic hepatitis D in patients with and without cirrhosis: results from the week 144 interim analysis of a phase 3 randomized study Open
Background Bulevirtide (BLV) is a first-in-class entry inhibitor for chronic hepatitis D (CHD) approved in Europe. Interim results from MYR301 (NCT03852719), a phase 3 randomized study, showed monotherapy with BLV 2 mg/d or 10 mg/d given s…
View article: Value and Kinetics of Virological Markers in the Natural Course of Chronic Hepatitis D Virus Infection
Value and Kinetics of Virological Markers in the Natural Course of Chronic Hepatitis D Virus Infection Open
Background and Aims Chronic hepatitis D virus (HDV) infection can cause severe liver disease. With new treatment options available, it is important to identify patients at risk for liver‐related complications. We aimed to investigate kinet…
View article: Insertion of a transjugular intrahepatic portosystemic shunt leads to sustained reversal of systemic inflammation in patients with decompensated liver cirrhosis
Insertion of a transjugular intrahepatic portosystemic shunt leads to sustained reversal of systemic inflammation in patients with decompensated liver cirrhosis Open
Background/Aims: Systemic Inflammation (SI) is considered a key mechanism in disease progression and development of complications in decompensated liver cirrhosis. SI is mainly driven by portal hypertension and bacterial translocation. Tra…
View article: HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replication
HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replication Open
The immune response mediated by CD8 T cells plays a critical role in controlling HBV infection and shows promise for therapeutic strategies aimed at achieving a functional cure. This study demonstrates that mutational escape within CD8 T-c…
View article: Long‐Term Follow‐Up of Neuropsychiatric Symptoms After Sustained Virological Response to Interferon‐Free and Interferon‐Based Hepatitis C Virus Treatment
Long‐Term Follow‐Up of Neuropsychiatric Symptoms After Sustained Virological Response to Interferon‐Free and Interferon‐Based Hepatitis C Virus Treatment Open
Chronic hepatitis C virus (HCV) infection can be associated with neuropsychiatric symptoms like fatigue and cognitive impairment, independent of the liver status. The present study aims to assess changes in the pattern and extent of neurop…
View article: MitoTempo treatment as an approach to cure persistent viral infections?
MitoTempo treatment as an approach to cure persistent viral infections? Open
Chronic viral infections are characterized by exhausted virus-specific T cells. Exhaustion is associated with mitochondrial dysfunction, revealing a possible target for treatment. Targeting these metabolic processes may interfere with the …
View article: Limited Value of <scp>HBV</scp>‐<scp>RNA</scp> for Relapse Prediction After Nucleos(t)ide Analogue Withdrawal in <scp>HBeAg</scp>‐negative Hepatitis B Patients
Limited Value of <span>HBV</span>‐<span>RNA</span> for Relapse Prediction After Nucleos(t)ide Analogue Withdrawal in <span>HBeAg</span>‐negative Hepatitis B Patients Open
International guidelines suggest cessation of nucleos(t)ide analogues (NA) independent of HBsAg loss in HBeAg‐negative patients after 2–3 years of viral suppression. Detectable HBV‐RNA levels at the time of NA cessation were linked to a be…
View article: Host response to influenza infections in human blood: association of influenza severity with host genetics and transcriptomic response
Host response to influenza infections in human blood: association of influenza severity with host genetics and transcriptomic response Open
Influenza virus infections are a major global health problem. Influenza can result in mild/moderate disease or progress to more severe disease, leading to high morbidity and mortality. Severity is thought to be primarily driven by immunopa…
View article: Predictors of hepatic flares after nucleos(t)ide analogue cessation – Results of a global cohort study (RETRACT-B study)
Predictors of hepatic flares after nucleos(t)ide analogue cessation – Results of a global cohort study (RETRACT-B study) Open
not applicable.
View article: Attenuated effector T cells are linked to control of chronic HBV infection
Attenuated effector T cells are linked to control of chronic HBV infection Open
Hepatitis B virus (HBV)-specific CD8+ T cells play a dominant role during acute-resolving HBV infection but are functionally impaired during chronic HBV infection in humans. These functional deficits have been linked with metabolic and phe…
View article: No value of non‐selective beta‐blockers after <scp>TIPS</scp>‐insertion
No value of non‐selective beta‐blockers after <span>TIPS</span>‐insertion Open
Summary Background and Aims Non‐selective beta‐blockers (NSBB) are a well‐established treatment in patients with clinically significant portal hypertension. However, their potential role after insertion of a transjugular intrahepatic porto…
View article: Host response to influenza infections in human blood: association of influenza severity with host genetics and transcriptomic response
Host response to influenza infections in human blood: association of influenza severity with host genetics and transcriptomic response Open
Introduction Influenza virus infections are a major global health problem. Influenza can result in mild/moderate disease or progress to more severe disease, leading to high morbidity and mortality. Severity is thought to be primarily drive…
View article: Immunomodulation and entry inhibition: selgantolimod’s double punch against hepatitis B virus
Immunomodulation and entry inhibition: selgantolimod’s double punch against hepatitis B virus Open
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