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View article: Transient Receptor Potential channels (TRP) in GtoPdb v.2025.1
Transient Receptor Potential channels (TRP) in GtoPdb v.2025.1 Open
The TRP superfamily of channels (nomenclature as agreed by NC-IUPHAR [177, 1080]), whose founder member is the Drosophila Trp channel, exists in mammals as six families; TRPC, TRPM, TRPV, TRPA, TRPP and TRPML based on amino acid homologies…
View article: ADPKD-Causing Missense Variants in Polycystin-1 Disrupt Cell Surface Localization or Polycystin Channel Function
ADPKD-Causing Missense Variants in Polycystin-1 Disrupt Cell Surface Localization or Polycystin Channel Function Open
Autosomal dominant polycystic kidney disease (ADPKD) is the leading monogenic cause of kidney failure and affects millions of people worldwide. Despite the prevalence of this monogenic disorder, our limited mechanistic understanding of ADP…
View article: Transient Receptor Potential channels (TRP) in GtoPdb v.2023.3
Transient Receptor Potential channels (TRP) in GtoPdb v.2023.3 Open
The TRP superfamily of channels (nomenclature as agreed by NC-IUPHAR [176, 1075]), whose founder member is the Drosophila Trp channel, exists in mammals as six families; TRPC, TRPM, TRPV, TRPA, TRPP and TRPML based on amino acid homologies…
View article: The Concise Guide to PHARMACOLOGY 2023/24: Ion channels
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels Open
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000…
View article: Transient Receptor Potential channels (TRP) in GtoPdb v.2023.2
Transient Receptor Potential channels (TRP) in GtoPdb v.2023.2 Open
The TRP superfamily of channels (nomenclature as agreed by NC-IUPHAR [176, 1072]), whose founder member is the Drosophila Trp channel, exists in mammals as six families; TRPC, TRPM, TRPV, TRPA, TRPP and TRPML based on amino acid homologies…
View article: Transient Receptor Potential channels (TRP) in GtoPdb v.2023.1
Transient Receptor Potential channels (TRP) in GtoPdb v.2023.1 Open
The TRP superfamily of channels (nomenclature as agreed by NC-IUPHAR [176, 1072]), whose founder member is the Drosophila Trp channel, exists in mammals as six families; TRPC, TRPM, TRPV, TRPA, TRPP and TRPML based on amino acid homologies…
Testing the ion-current model for flagellar length sensing and IFT regulation Open
Eukaryotic cilia and flagella are microtubule-based organelles whose relatively simple shape makes them ideal for investigating the fundamental question of organelle size regulation. Most of the flagellar materials are transported from the…
Testing the ion-current model for flagellar length sensing and IFT regulation Open
Eukaryotic cilia and flagella are microtubule-based organelles whose relatively simple shape makes them ideal for investigating the fundamental question of organelle size regulation. Most of the flagellar materials are transported from the…
Total internal reflection time series for "Conversion of anterograde into retrograde trains is an intrinsic property of intraflagellar transport" Open
Total internal reflection time series recordings on Chlamydomonas Reinhardtii cells gliding on a glass surface. The dataset includes calcium signaling of pf2 PF2-GcAMP6 cells as well a recordings of IFT46-mNeonGreen cells during ciliary we…
The cilia enriched oxysterol 7β,27-DHC is required for polycystin activation Open
PC-1 and PC-2 form a heteromeric ion channel complex (hereafter called the Polycystin complex) that is abundantly expressed on primary cilia of renal epithelial cells. Mutations within the polycystin complex cause Autosomal Dominant Polycy…
View article: Transient Receptor Potential channels (TRP) in GtoPdb v.2022.1
Transient Receptor Potential channels (TRP) in GtoPdb v.2022.1 Open
The TRP superfamily of channels (nomenclature as agreed by NC-IUPHAR [159, 999]), whose founder member is the Drosophila Trp channel, exists in mammals as six families; TRPC, TRPM, TRPV, TRPA, TRPP and TRPML based on amino acid homologies.…
View article: THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels Open
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasi…
View article: Transient Receptor Potential channels (TRP) in GtoPdb v.2021.3
Transient Receptor Potential channels (TRP) in GtoPdb v.2021.3 Open
The TRP superfamily of channels (nomenclature as agreed by NC-IUPHAR [159, 997]), whose founder member is the Drosophila Trp channel, exists in mammals as six families; TRPC, TRPM, TRPV, TRPA, TRPP and TRPML based on amino acid homologies.…
Electrophysiological Recordings of the Polycystin Complex in the Primary Cilium of Cultured Mouse IMCD-3 Cell Line Open
PC-1 and PC-2 form an ion channel complex called the polycystin complex, which predominantly localizes to a small hair-like organelle called the primary cilium. The polycystin complex permeates cations, K+, Na+, and Ca2+, and has an unusua…
The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus Open
Mutations in the polycystin proteins, PC-1 and PC-2, result in autosomal dominant polycystic kidney disease (ADPKD) and ultimately renal failure. PC-1 and PC-2 enrich on primary cilia, where they are thought to form a heteromeric ion chann…
Author response: The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Mutations in the polycystin p…
View article: Transient Receptor Potential channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Transient Receptor Potential channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Open
The TRP superfamily of channels (nomenclature as agreed by NC-IUPHAR [145, 915]), whose founder member is the Drosophila Trp channel, exists in mammals as six families; TRPC, TRPM, TRPV, TRPA, TRPP and TRPML based on amino acid homologies.…
New insights into ion channel‐dependent signalling during left‐right patterning Open
The left‐right organizer (LRO) in the mouse consists of pit cells within the depression, located at the end of the developing notochord, also known as the embryonic node and crown cells lining the outer periphery of the node. Cilia on pit …
Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia Open
Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches. The mech…
Author response: Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Cell division is essential to…