Markus Donix
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View article: Beobachtungsstudie zur Koinzidenz von Alzheimer-Erkrankung und idiopathischem Normaldruckhydrozephalus: Analyse von Koinzidenz, deren Einfluss auf das Ansprechen im Liquorablassversuch und zerebrovaskulärer Kopathologie
Beobachtungsstudie zur Koinzidenz von Alzheimer-Erkrankung und idiopathischem Normaldruckhydrozephalus: Analyse von Koinzidenz, deren Einfluss auf das Ansprechen im Liquorablassversuch und zerebrovaskulärer Kopathologie Open
Zusammenfassung Ziel der Arbeit Analyse der Häufigkeit einer komorbiden Alzheimer-Erkrankung (AD) bei Patienten mit Verdacht auf idiopathischen Normaldruckhydrozephalus (iNPH) und deren Effekt auf das Ansprechen im Liquorablassversuch sowi…
View article: The comorbidity profiles and medication issues of patients with multiple system atrophy: a systematic cross-sectional analysis
The comorbidity profiles and medication issues of patients with multiple system atrophy: a systematic cross-sectional analysis Open
View article: Mild Behavioral Impairment
Mild Behavioral Impairment Open
Socially inappropriate behavior accompanies and modulates delinquency across the lifespan. In contrast to young people, the emergence of such traits among older individuals could indicate incipient neurodegenerative disease. Before develop…
View article: The comorbidity and co-medication profile of patients with progressive supranuclear palsy
The comorbidity and co-medication profile of patients with progressive supranuclear palsy Open
Background Progressive supranuclear palsy (PSP) is usually diagnosed in elderly. Currently, little is known about comorbidities and the co-medication in these patients. Objectives To explore the pattern of comorbidities and co-medication i…
View article: Comorbid cerebral amyloid angiopathy in dementia and prodromal stages—Prevalence and effects on cognition
Comorbid cerebral amyloid angiopathy in dementia and prodromal stages—Prevalence and effects on cognition Open
Objectives To determine the contribution of cerebral amyloid angiopathy to cognitive impairment in MCI and dementia. Methods Patients with subjective memory impairment (SMI), amnestic and non‐amnestic mild cognitive impairment ((n)aMCI), A…
View article: Analyse zur Häufigkeit einer gerinnungshemmenden Medikation bei Patientinnen mit kognitiven Störungen und zerebraler Amyloidangiopathie (CAA)
Analyse zur Häufigkeit einer gerinnungshemmenden Medikation bei Patientinnen mit kognitiven Störungen und zerebraler Amyloidangiopathie (CAA) Open
Zusammenfassung Ziel der Arbeit Analyse der Häufigkeit einer zerebralen Amyloidangiopathie (CAA) bei Patient inn en mit kognitiven Störungen und der Häufigkeit einer Koinzidenz von gerinnungshemmender Therapie und CAA. Explorative Analyse …
View article: Predictors of subjective cognitive deficits in patients with mild cognitive impairment
Predictors of subjective cognitive deficits in patients with mild cognitive impairment Open
Background Detailed examination of cognitive deficits in patients with mild cognitive impairment (MCI) yields substantial diagnostic and prognostic value, specifically with respect to memory. Magnitude and characteristics of subjective cog…
View article: Intrazerebrale Blutungen unter Plättchenaggregationshemmung und oraler Antikoagulation bei Patienten mit zerebraler Amyloidangiopathie
Intrazerebrale Blutungen unter Plättchenaggregationshemmung und oraler Antikoagulation bei Patienten mit zerebraler Amyloidangiopathie Open
Zusammenfassung Die Durchführung einer oralen Antikoagulation ist bei Patienten mit einer zerebralen Amyloidangiopathie eine therapeutische Herausforderung. Die Assoziation der zerebralen Amyloidangiopathie mit Lobärblutungen, eine hohe Mo…
View article: Aktuelle Befunde zur Koinzidenz von zerebraler Amyloidangiopathie und Alzheimer-Erkrankung
Aktuelle Befunde zur Koinzidenz von zerebraler Amyloidangiopathie und Alzheimer-Erkrankung Open
Zusammenfassung Die zerebrale Amyloidangiopathie (CAA) tritt trotz verschiedener Pathomechanismen häufig koinzident zur Alzheimer-Demenz auf. Sie moduliert kognitive Defizite im Rahmen der Alzheimer-Erkrankung (AD) annehmbar durch additive…
View article: Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder
Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder Open
Background Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with …
View article: Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder
Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder Open
View article: Delinquentes Verhalten im Rahmen frontotemporaler Demenzen und der Alzheimer-Erkrankung
Delinquentes Verhalten im Rahmen frontotemporaler Demenzen und der Alzheimer-Erkrankung Open
Zusammenfassung Seniorenkriminalität ist insgesamt ein seltenes Phänomen. Bei älteren Straftätern hat es die Justiz in hohem Maß mit Ersttätern zu tun, die mehrheitlich männlichen Geschlechts sind. Eine mögliche Ursache von Erstkriminalitä…
View article: Relation of retinal and hippocampal thickness in patients with amnestic mild cognitive impairment and healthy controls
Relation of retinal and hippocampal thickness in patients with amnestic mild cognitive impairment and healthy controls Open
Objective Investigating retinal thickness may complement existing biological markers for dementia and other neurodegenerative diseases. Although retinal thinning is predictive for cognitive decline, it remains to be investigated if and how…
View article: Familial risk of dementia and mediators of memory clinic referrals
Familial risk of dementia and mediators of memory clinic referrals Open
Cognitive deficits occur frequently among older people. Because the underlying aetiologies may be heterogeneous, diagnostic assessments include clinical and neuropsychological evaluations, as well as the examination of biological markers, …
View article: Impact of cognitive reserve on clinical and neuropsychological measures in patients with mild cognitive impairment
Impact of cognitive reserve on clinical and neuropsychological measures in patients with mild cognitive impairment Open
Objective: Cognitive reserve influences age of onset, speed of progression, and clinical manifestations of Alzheimer’s disease. We investigated whether cognitive reserve interacts with clinical and neuropsychological parameters in mild cog…
View article: Farewell to a teacher
Farewell to a teacher Open
This article was migrated. The article was marked as recommended. There are frequent discussions about the challenges of teaching in medical school, often focusing on technological aspects or time constraints. The retirement of one of my m…
View article: Education correction for neurocognitive testing
Education correction for neurocognitive testing Open
Comprehensive neuropsychological assessments, composed of specific tests targeting different aspects of cognition, are standard diagnostic tools to characterise the single- or multidomain impairments due to neurodegeneration, depression, o…
View article: Association between solar insolation and a history of suicide attempts in bipolar I disorder
Association between solar insolation and a history of suicide attempts in bipolar I disorder Open
View article: Association between solar insolation and a history of suicide attempts in bipolar I disorder
Association between solar insolation and a history of suicide attempts in bipolar I disorder Open
In many international studies, rates of completed suicide and suicide attempts have a seasonal pattern that peaks in spring or summer. This exploratory study investigated the association between solar insolation and a history of suicide at…
View article: Family History of Alzheimer’s Disease and Subjective Memory Performance
Family History of Alzheimer’s Disease and Subjective Memory Performance Open
People with a first-degree family history of Alzheimer’s disease are at an increased risk of developing dementia. Subjective memory impairment among individuals with no measurable cognitive deficits may also indicate elevated dementia risk…
View article: Extrinsic and Intrinsic Help-Seeking Motivation in the Assessment of Cognitive Decline
Extrinsic and Intrinsic Help-Seeking Motivation in the Assessment of Cognitive Decline Open
Diagnostic assessments for dementia include the evaluation of subjective memory impairment, dementia worries, or depressive symptoms. Data on the predictive value of these factors remain unclear, and varying help-seeking behavior may contr…
View article: Accelerated Age-Dependent Hippocampal Volume Loss in Parkinson Disease With Mild Cognitive Impairment
Accelerated Age-Dependent Hippocampal Volume Loss in Parkinson Disease With Mild Cognitive Impairment Open
Background: Patients with Parkinson disease are at high risk of developing dementia. During the course of the disease, a substantial number of patients will experience a cognitive decline, indicating the dynamics of the underlying neuropat…
View article: MAPT mutation associated with frontotemporal dementia and parkinsonism (FTDP-17)
MAPT mutation associated with frontotemporal dementia and parkinsonism (FTDP-17) Open
We present a 56-year-old patient suffering from frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17). The history included a three-generation pedigree and the patient was found to be a mutation carrier. The diagnosis…
View article: Our Hidden Patients
Our Hidden Patients Open
It is still dark outside. I like coming in early to prepare for rounds or to go through some patient records before I meet my colleagues at the daily morning conference. The sound of an incoming e-mail catches my attention. The well-balanc…
View article: Precuneus Structure Changes in Amnestic Mild Cognitive Impairment
Precuneus Structure Changes in Amnestic Mild Cognitive Impairment Open
Patients with amnestic mild cognitive impairment (aMCI) are at risk for developing Alzheimer’s disease. Due to their prominent memory impairment, structural magnetic resonance imaging (MRI) often focuses on the hippocampal region. However,…
View article: Family History of Alzheimer’s Disease and Cortical Thickness in Patients With Dementia
Family History of Alzheimer’s Disease and Cortical Thickness in Patients With Dementia Open
A first-degree family history of Alzheimer’s disease reflects genetic risks for the neurodegenerative disorder. Recent imaging data suggest localized effects of genetic risks on brain structure in healthy people. It is unknown whether this…
View article: Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer’s Disease
Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer’s Disease Open
Genetic and environmental protective factors and risks modulate brain structure and function in neurodegenerative diseases and their preclinical stages. We wanted to investigate whether the years of formal education, a proxy measure for co…
View article: Preventive brain radio‐chemotherapy alters plasticity associated metabolite profile in the hippocampus but seems to not affect spatial memory in young leukemia patients
Preventive brain radio‐chemotherapy alters plasticity associated metabolite profile in the hippocampus but seems to not affect spatial memory in young leukemia patients Open
Background Neuronal plasticity leading to evolving reorganization of the neuronal network during entire lifespan plays an important role for brain function especially memory performance. Adult neurogenesis occurring in the dentate gyrus of…
View article: Effects of Physical Activity Training in Patients with Alzheimer’s Dementia: Results of a Pilot RCT Study
Effects of Physical Activity Training in Patients with Alzheimer’s Dementia: Results of a Pilot RCT Study Open
ClinicalTrials.gov NCT02196545.
View article: Einfluss kombinierter Radio- / Chemotherapie auf die Konzentration plastizitätskorrelierter Hirnmetabolite und das räumliche Gedächtnis bei Patienten mit Akuter Lymphatischer Leukämie (ALL)
Einfluss kombinierter Radio- / Chemotherapie auf die Konzentration plastizitätskorrelierter Hirnmetabolite und das räumliche Gedächtnis bei Patienten mit Akuter Lymphatischer Leukämie (ALL) Open