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View article: Asia‐Inclusive Global Development of Enpatoran: Results of an Ethno‐Bridging Study, Intrinsic/Extrinsic Factor Assessments and Disease Trajectory Modeling to Inform Design of a Phase II Multiregional Clinical Trial
Asia‐Inclusive Global Development of Enpatoran: Results of an Ethno‐Bridging Study, Intrinsic/Extrinsic Factor Assessments and Disease Trajectory Modeling to Inform Design of a Phase II Multiregional Clinical Trial Open
Enpatoran is a novel, highly selective, and potent dual toll‐like receptor (TLR)7 and TLR8 inhibitor currently under development for the treatment of autoimmune disorders including systemic lupus erythematosus (SLE), cutaneous lupus erythe…
View article: Avelumab internalization by human circulating immune cells is mediated by both Fc gamma receptor and PD-L1 binding
Avelumab internalization by human circulating immune cells is mediated by both Fc gamma receptor and PD-L1 binding Open
Avelumab is an IgG1 anti-programmed death ligand 1 (anti-PD-L1) monoclonal antibody that has been approved as a monotherapy for metastatic Merkel cell carcinoma and advanced urothelial carcinoma, and in combination with axitinib for advanc…
View article: 195 Avelumab internalization and lysosomal degradation by circulating immune cells in human is mediated by both Fc gamma Receptor (FcgR) and PD-L1 binding
195 Avelumab internalization and lysosomal degradation by circulating immune cells in human is mediated by both Fc gamma Receptor (FcgR) and PD-L1 binding Open
Background Receptor-mediated endocytosis results in antibody recycling (via endosomes) or degradation (in lysosomes). Avelumab is a human anti–PD-L1 antibody, with wild type (WT) IgG1 isotype and effector function, approved for treating ce…
View article: In vitro and in vivo drug disposition of cilengitide in animals and human
In vitro and in vivo drug disposition of cilengitide in animals and human Open
Cilengitide is very low permeable (1.0 nm/sec) stable cyclic pentapeptide containing an Arg‐Gly‐Asp motif responsible for selective binding to α v β 3 and α v β 5 integrins administered intravenously (i.v.). In vivo studies in the mouse an…