Markus Glatzel
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View article: Evidence for different seeding activities of misfolded tau in classical and rapidly progressive Alzheimer's disease
Evidence for different seeding activities of misfolded tau in classical and rapidly progressive Alzheimer's disease Open
Alzheimer's disease (AD) may display various clinical phenotypes with different disease progressions, such as rapidly progressive Alzheimer's disease (rpAD) type. The reason for clinical heterogeneity is still unknown and not predictable. …
View article: Spatial transcriptomics of cerebral amyloid angiopathy and amyloid‐β related angiitis
Spatial transcriptomics of cerebral amyloid angiopathy and amyloid‐β related angiitis Open
Background The removal of amyloid‐β (Aβ) by antibodies has revolutionized the treatment landscape of Alzheimer's disease (AD). Vascular Aβ has been implicated in the emergence of amyloid‐related imaging abnormalities (ARIA). A better under…
View article: <scp>ApoE4</scp> Homozygosity Is Associated With Increased Microglia Activation in Fatal <scp>COVID</scp> ‐19
<span>ApoE4</span> Homozygosity Is Associated With Increased Microglia Activation in Fatal <span>COVID</span> ‐19 Open
Apolipoprotein E4 (APOE4) is recognized as a major risk factor for disorders such as Alzheimer's disease and may play a role in the dysregulation of microglia in various neurodegenerative conditions. APOE variants have also been proposed a…
View article: Extracellular Vesicles Released From Cortical Neurons Influence Spontaneous Activity of Recipient Neurons
Extracellular Vesicles Released From Cortical Neurons Influence Spontaneous Activity of Recipient Neurons Open
Extracellular vesicles (EVs) are membranous structures that cells release into the extracellular space. EVs carry various molecules such as proteins, lipids, and nucleic acids, and serve as specialized transporters to influence other cells…
View article: Deep-tissue two-photon brain imaging enabled by a tunable fiber-optic dispersive wave generator
Deep-tissue two-photon brain imaging enabled by a tunable fiber-optic dispersive wave generator Open
Here, we present a fiber-optic dispersive wave generator for highly-efficient, wavelength-tunable ultrashort pulse generation, enabling multicolor deep-tissue two-photon imaging of neuronal and vascular structures in fixed, labeled mouse b…
View article: Multiplexed Brain and Visceral Two-Photon Imaging Using a Simulation-Guided Ultrafast Three-Color Fiber Laser
Multiplexed Brain and Visceral Two-Photon Imaging Using a Simulation-Guided Ultrafast Three-Color Fiber Laser Open
Multicolor two-photon microscopy is an essential tool in modern life sciences, enabling simultaneous, high-resolution imaging of multiple cellular structures and dynamic processes within complex biomedical systems. Realizing its full poten…
View article: The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis Open
Inflammation, aberrant proteostasis, and energy depletion are hallmarks of neurodegenerative diseases such as multiple sclerosis (MS). However, the interplay between inflammation, proteasomal dysfunction in neurons, and its consequences fo…
View article: Altered CD4 T cell response in oligometatastic non-small cell lung cancer brain metastasis
Altered CD4 T cell response in oligometatastic non-small cell lung cancer brain metastasis Open
Lung cancer is the leading cause of cancer mortality globally, with brain metastasis (BM) in 40% of advanced non-small-cell lung cancer (NSCLC) cases. In 15% of these cases, the brain is the sole affected organ (oligometastasis), which cor…
View article: Extracellular vesicles released from cortical neurons influence spontaneous activity of recipient neurons.
Extracellular vesicles released from cortical neurons influence spontaneous activity of recipient neurons. Open
Extracellular vesicles (EVs) are membranous structures that cells release into the extracellular space. EVs carry various molecules such as proteins, lipids, and nucleic acids, and serve as specialized transporters to influence other cells…
View article: Deep-Tissue Two-Photon Brain Imaging Enabled by a Tunable Fiber-Optic Dispersive Wave Generator
Deep-Tissue Two-Photon Brain Imaging Enabled by a Tunable Fiber-Optic Dispersive Wave Generator Open
Here, we present a fiber-optic dispersive wave generator for highly-efficient, wavelength-tunable ultrashort pulse generation, enabling multicolor deep-tissue two-photon imaging of neuronal and vascular structures in labeled mouse brain. G…
View article: Comorbidities in early-onset sporadic versus presenilin-1 mutation-associated Alzheimer disease dementia: Evidence for dependency on Alzheimer disease neuropathological changes
Comorbidities in early-onset sporadic versus presenilin-1 mutation-associated Alzheimer disease dementia: Evidence for dependency on Alzheimer disease neuropathological changes Open
Studying comorbidities in early onset Alzheimer disease (AD) may provide an advantageous perspective on their pathogenesis because aging factors may be largely inoperative for these subjects. We compared AD comorbidities between early-onse…
View article: Efficient enzyme‐free isolation of brain‐derived extracellular vesicles
Efficient enzyme‐free isolation of brain‐derived extracellular vesicles Open
Extracellular vesicles (EVs) have gained significant attention as pathology mediators and potential diagnostic tools for neurodegenerative diseases. However, isolation of brain‐derived EVs (BDEVs) from tissue remains challenging, often inv…
View article: Comment on “Extracellular Vesicles Slow Down Aβ(1–42) Aggregation by Interfering with the Amyloid Fibril Elongation Step”
Comment on “Extracellular Vesicles Slow Down Aβ(1–42) Aggregation by Interfering with the Amyloid Fibril Elongation Step” Open
Halipi et al. explored the impact of extracellular vesicles (EVs) on amyloid-β (Aβ) aggregation. They concluded that EVs reduce Aβ aggregation, as seen by shorter and thicker fibrils. While we agree with the complex role of EVs in Alzheime…
View article: Severe mpox in an immunocompromised patient complicated by deep tissue infection: A case report
Severe mpox in an immunocompromised patient complicated by deep tissue infection: A case report Open
Our data provide evidence that Tecovirimat treatment selects for compartimentalized viral mutations (A288P). While the patient clinically benefited from repeated tecovirimat course, emergence of viral muations and deep tissue infection emp…
View article: Multiplexed Fixed Single Cell RNA Sequencing of frozen human post mortem brain v1
Multiplexed Fixed Single Cell RNA Sequencing of frozen human post mortem brain v1 Open
This protocol describes the processing of post-mortem frozen brain tissue for fixed single-cell sequencing using 10x Genomics for the library preparation. This protocol can be applied and generalized for infectious tissues that need to be …
View article: Integrated analyses reveal two molecularly and clinically distinct subtypes of H3 K27M-mutant diffuse midline gliomas with prognostic significance
Integrated analyses reveal two molecularly and clinically distinct subtypes of H3 K27M-mutant diffuse midline gliomas with prognostic significance Open
H3 K27M-altered diffuse midline gliomas (DMGs) are highly malignant tumours that arise in the midline structures of the CNS. Most DMGs carry an H3 K27M-mutation in one of the genes encoding for histone H3. Recent studies suggested that epi…
View article: High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains
High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains Open
The underlying pathogenesis of neurological sequelae in post-COVID-19 patients remains unclear. Here, we used multidimensional spatial immune phenotyping and machine learning methods on brains from initial COVID-19 survivors to identify th…
View article: Inefficient tissue immune response against MPXV in an immunocompromised mpox patient
Inefficient tissue immune response against MPXV in an immunocompromised mpox patient Open
The recent outbreak of monkeypox virus (MPXV) was unprecedented in its size and distribution. Those living with uncontrolled HIV and low CD4 T cell counts might develop a fulminant clinical mpox course with increased mortality, secondary i…
View article: <i>APOE3</i> Christchurch Heterozygosity and Autosomal Dominant Alzheimer’s Disease
<i>APOE3</i> Christchurch Heterozygosity and Autosomal Dominant Alzheimer’s Disease Open
Clinical data supported a delayed onset of cognitive impairment in persons who were heterozygous for the APOE3 Ch variant in a kindred with a high prevalence of autosomal dominant Alzheimer's disease. (Funded by Good Ventures and others.).
View article: The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis
The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis Open
A disturbed balance between excitation and inhibition (E/I balance) is increasingly recognized as a key driver of neurodegeneration in multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system. To understand how…
View article: STING orchestrates the neuronal inflammatory stress response in multiple sclerosis
STING orchestrates the neuronal inflammatory stress response in multiple sclerosis Open
Inflammation-induced neurodegeneration is a defining feature of multiple sclerosis (MS), yet the underlying mechanisms remain unclear. By dissecting the neuronal inflammatory stress response, we discovered that neurons in MS and its mouse …
View article: NSCLC patients with oligo-metastatic brain disease show an altered CD4 T-cells immune profile
NSCLC patients with oligo-metastatic brain disease show an altered CD4 T-cells immune profile Open
Background Lung cancer is the leading cause of cancer-related deaths worldwide, with brain metastasis (BM) occurring in 40% of advanced non-small cell lung cancer (NSCLC) patients. In 15% of these patients, the brain is the only affected o…
View article: Microgliosis, astrogliosis and loss of aquaporin-4 polarity in frontal cortex of COVID-19 patients
Microgliosis, astrogliosis and loss of aquaporin-4 polarity in frontal cortex of COVID-19 patients Open
The severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), causing human coronavirus disease 2019 (COVID-19), not only affects the respiratory tract, but also impacts other organs including the brain. A considerable number of C…
View article: Circulating extracellular vesicles as biomarker for diagnosis, prognosis, and monitoring in glioblastoma patients
Circulating extracellular vesicles as biomarker for diagnosis, prognosis, and monitoring in glioblastoma patients Open
Background Extracellular vesicles (EVs) obtained by noninvasive liquid biopsy from patient blood can serve as biomarkers. Here, we investigated the potential of circulating plasma EVs to serve as an indicator in the diagnosis, prognosis, a…
View article: A novel mouse model for N-terminal truncated Aβ2-x generation through meprin β overexpression in astrocytes
A novel mouse model for N-terminal truncated Aβ2-x generation through meprin β overexpression in astrocytes Open
Neurotoxic amyloid-β (Aβ) peptides cause neurodegeneration in Alzheimer’s disease (AD) patients’ brains. They are released upon proteolytic processing of the amyloid precursor protein (APP) extracellularly at the β-secretase site and intra…
View article: Efficient enzyme-free isolation of brain-derived extracellular vesicles
Efficient enzyme-free isolation of brain-derived extracellular vesicles Open
Extracellular vesicles (EVs) have gained significant attention as pathology mediators and potential diagnostic tools for neurodegenerative diseases. However, isolation of brain-derived EVs (BDEVs) from tissue remains challenging, often inv…