Markus H. Heim
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View article: Whole-Genome Sequencing of Hepatitis B Virus Genotypes E and A in Zambia Reveals Limited Viral Diversity in HIV Coinfection
Whole-Genome Sequencing of Hepatitis B Virus Genotypes E and A in Zambia Reveals Limited Viral Diversity in HIV Coinfection Open
Background The molecular characteristics of hepatitis B virus (HBV) in Africa, including the impact of HIV coinfection, are poorly understood. Methods We performed whole-genome sequencing (WGS) on biospecimens collected before antiviral th…
View article: The HDAC inhibitor romidepsin renders liver cancer vulnerable to RTK targeting and immunologically active
The HDAC inhibitor romidepsin renders liver cancer vulnerable to RTK targeting and immunologically active Open
Histone deacetylases (HDACs) are epigenetic regulators frequently altered in cancer. Here we report that overexpression of HDAC1/2 occurs in Hepatocellular Carcinoma (HCC) patients, correlating with poor prognosis. We show that romidepsin,…
View article: Multi-omics of sorafenib responsiveness in HCC patients
Multi-omics of sorafenib responsiveness in HCC patients Open
Tumor response rates to targeted therapy are generally low. This poses an urgent medical need to identify molecular mechanisms determining responsiveness to inform therapy. We describe the first longitudinal deepscale multi-omic analysis (…
View article: Circulating monocytes upregulate CD52 and sustain innate immune function in cirrhosis unless acute decompensation emerges
Circulating monocytes upregulate CD52 and sustain innate immune function in cirrhosis unless acute decompensation emerges Open
Monocyte dysfunction substantially contributes to infection susceptibility, which is a major determinant of the prognosis of patients with cirrhosis and represents a major unmet therapeutic need. Its underlying mechanisms remain poorly und…
View article: Assessment of Product Carbon Footprint Reduction Potential Using Lightweight Rotor Components for Electric Traction Motors
Assessment of Product Carbon Footprint Reduction Potential Using Lightweight Rotor Components for Electric Traction Motors Open
The mobility sector is currently undergoing one of the most profound transformation processes in its history. With ambitious climate targets on the horizon, there is a pronounced shift towards electric traction drives. However, in comparis…
View article: The carbonyl nucleobase adduct M3Ade is a potent antigen for adaptive polyclonal MR1-restricted T cells
The carbonyl nucleobase adduct M3Ade is a potent antigen for adaptive polyclonal MR1-restricted T cells Open
The major histocompatibility complex (MHC) class I-related molecule MHC-class-I-related protein 1 (MR1) presents metabolites to distinct MR1-restricted T cell subsets, including mucosal-associated invariant T (MAIT) and MR1T cells. However…
View article: Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease
Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease Open
Metabolic dysfunction–associated steatotic liver disease (MASLD) is a multisystemic disease with a multifactorial pathogenesis involving dietary, environmental, and genetic factors. Previous mouse models suggested that circadian misalignme…
View article: Adenosine Receptor 3 in Liver Cancer: Expression Variability, Epigenetic Modulation, and Enhanced Histone Deacetylase Inhibitor Effects
Adenosine Receptor 3 in Liver Cancer: Expression Variability, Epigenetic Modulation, and Enhanced Histone Deacetylase Inhibitor Effects Open
ADORA3 expression varies considerably in HCC or CCA, ranging from high to absent receptor detection. This observation might help to identify patients for clinical studies. Additionally, Namodenoson's epigenetic modulating activity suggests…
View article: Meta-analysis reveals limited reproducibility of lncRNA-related findings in hepatocellular carcinoma research
Meta-analysis reveals limited reproducibility of lncRNA-related findings in hepatocellular carcinoma research Open
Background & Aims The human genome comprises tens of thousands of long non-coding RNAs (lncRNAs), whose functionality is highly debated. In the field of hepatocellular carcinoma (HCC) research, as for other cancer types, lncRNAs are increa…
View article: Effect of Direct Acting Antiviral Drugs on the Occurrence and Recurrence of Intra- and Extra-Hepatic Malignancies in Patients with Chronic Hepatitis C Virus Infection
Effect of Direct Acting Antiviral Drugs on the Occurrence and Recurrence of Intra- and Extra-Hepatic Malignancies in Patients with Chronic Hepatitis C Virus Infection Open
Introduction: The use of direct-acting antivirals (DAAs) has drastically changed the management of HCV-infected patients by achieving a 95–98% sustained virologic response (SVR) and reducing morbidity and mortality in this population. Howe…
View article: Inhibition of the transmembrane transporter ABCB1 overcomes resistance to doxorubicin in patient-derived organoid models of HCC
Inhibition of the transmembrane transporter ABCB1 overcomes resistance to doxorubicin in patient-derived organoid models of HCC Open
Background: Transarterial chemoembolization is the first-line treatment for intermediate-stage HCC. However, the response rate to transarterial chemoembolization varies, and the molecular mechanisms underlying variable responses are poorly…
View article: Distinct circulating monocytes up-regulate CD52 and sustain innate immune function in patients with cirrhosis unless acute decompensation emerges
Distinct circulating monocytes up-regulate CD52 and sustain innate immune function in patients with cirrhosis unless acute decompensation emerges Open
Background & Aims Infectious complications determine the prognosis of cirrhosis patients. Their infection susceptibility relates to the development of immuneparesis, a complex interplay of different immunosuppressive cells and soluble fact…
View article: Targeting the expansion of myeloid-derived suppressor cells in liver cirrhosis
Targeting the expansion of myeloid-derived suppressor cells in liver cirrhosis Open
Background and aims Previously, we identified immune-suppressive circulating monocytic myeloid-derived suppressor cells (M-MDSC) in patients with cirrhosis and liver failure, which increased with disease severity and were associated with i…
View article: Ribociclib-induced liver injury: a case report
Ribociclib-induced liver injury: a case report Open
Background Idiosyncratic drug-induced liver injury (DILI) is a rare, unpredictable hepatic adverse event and the most common cause of acute liver failure in Europe and the US. Ribociclib is a potent Cyclin-dependent kinase 4 and 6 (CDK4/6)…
View article: Inflammation-induced TRIM21 represses hepatic steatosis by promoting the ubiquitination of lipogenic regulators
Inflammation-induced TRIM21 represses hepatic steatosis by promoting the ubiquitination of lipogenic regulators Open
Nonalcoholic steatohepatitis (NASH) is a leading cause for chronic liver diseases. Current therapeutic options are limited due to an incomplete mechanistic understanding of how steatosis transitions to NASH. Here we show that the TRIM21 E3…
View article: Arginine reprograms metabolism in liver cancer via RBM39
Arginine reprograms metabolism in liver cancer via RBM39 Open
Metabolic reprogramming is a hallmark of cancer. However, mechanisms underlying metabolic reprogramming and how altered metabolism in turn enhances tumorigenicity are poorly understood. Here, we report that arginine levels are elevated in …
View article: Loss of CYP2D6 sensitizes hepatocellular carcinomas and neuroblastomas to talazoparib
Loss of CYP2D6 sensitizes hepatocellular carcinomas and neuroblastomas to talazoparib Open
Cancers often have reduced allelic diversity because of loss of heterozygosity (LOH). Therefore, tumors arising in patients heterozygous for a functional and a loss-of-functon(LoF) allele may lose the functional allele, rendering them sens…
View article: Canagliflozin and Metabolic Associated Fatty Liver Disease in Patients With Diabetes Mellitus: New Insights From CANVAS
Canagliflozin and Metabolic Associated Fatty Liver Disease in Patients With Diabetes Mellitus: New Insights From CANVAS Open
Context Metabolic dysfunction–associated fatty liver disease (MAFLD) is highly prevalent among patients with type 2 diabetes mellitus (T2DM); however, there is still no approved pharmacological treatment. Sodium-glucose cotransporter 2 (SG…
View article: Studying Hepatitis Virus-Host Interactions in Patient Liver Biopsies
Studying Hepatitis Virus-Host Interactions in Patient Liver Biopsies Open
Infectious diseases are a major contributor to human suffering and the associated socioeconomic burden worldwide. A better understanding of human pathogen-host interactions is a prerequisite for the development of treatment strategies aime…
View article: Multi-omics subtyping of hepatocellular carcinoma patients using a Bayesian network mixture model
Multi-omics subtyping of hepatocellular carcinoma patients using a Bayesian network mixture model Open
Comprehensive molecular characterization of cancer subtypes is essential for predicting clinical outcomes and searching for personalized treatments. We present bnClustOmics, a statistical model and computational tool for multi-omics unsupe…