Markus Jäger
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View article: Unveiling Metabolic Subtypes in Endometrial Cancer Cell Lines: Insights from Metabolomic Analysis Under Standard and Stress Conditions
Unveiling Metabolic Subtypes in Endometrial Cancer Cell Lines: Insights from Metabolomic Analysis Under Standard and Stress Conditions Open
Endometrial carcinoma (EC) is the most common malignancy of the female reproductive tract, with increasing incidence driven by aging populations and obesity. While molecular classification has improved diagnostic precision, the identificat…
View article: Intraoperative Biologization of β-TCP and PCL-TCP by Autologous Proteins
Intraoperative Biologization of β-TCP and PCL-TCP by Autologous Proteins Open
Protein adsorption on orthopedic biomaterials during the initial intraoperative contact critically influences biological responses and osseointegration. Osteoconductive grafts such as β-tricalcium phosphate (β-TCP) and poly (ε-caprolactone…
View article: KI in der instrumentellen Ganganalyse
KI in der instrumentellen Ganganalyse Open
View article: Orthopädie der Zukunft
Orthopädie der Zukunft Open
View article: An intelligible AI-driven decision support system for poststroke mobility assessment
An intelligible AI-driven decision support system for poststroke mobility assessment Open
Objective: Long-term mobility impairment is a sequel of stroke victims which requires intensive medical and physiotherapeutic care. Detailed assessment of therapeutic success is relevant to achieving efficacy, but requires expert knowledge…
View article: CD9+ and CD82+ extracellular vesicles in synovial fluid differentiate aseptic from septic endoprosthesis loosening
CD9+ and CD82+ extracellular vesicles in synovial fluid differentiate aseptic from septic endoprosthesis loosening Open
Aim: Extracellular vesicles (EVs) hold great promise as emerging biomarkers for a variety of diseases. However, their clinical application is still hindered by complex and time-consuming isolation procedures. A clinically relevant scenario…
View article: Lysine carbamoylation during urea denaturation remodels the energy landscape of human transthyretin dissociation linked to unfolding
Lysine carbamoylation during urea denaturation remodels the energy landscape of human transthyretin dissociation linked to unfolding Open
Chemical denaturants such as urea have become indispensable in modern protein science for measuring the energetics of protein folding and assembly. Denaturants bind to and preferentially stabilize denatured states, folding transition state…
View article: Serum Proteome Profiling Identifies N-cadherin and c-Met as Candidates for the Early Detection of therapeutic Response to Neoadjuvant Chemotherapy in Breast Cancer: A retrospective Study
Serum Proteome Profiling Identifies N-cadherin and c-Met as Candidates for the Early Detection of therapeutic Response to Neoadjuvant Chemotherapy in Breast Cancer: A retrospective Study Open
Background: Neoadjuvant chemotherapy (NACT) for non-metastatic breast cancer is often preferred over adjuvant chemotherapy to shrink tumours and facilitate surgical removal. NACT typically comprises 8 cycles over 20–24 weeks: 4 cycles of a…
View article: Functional Knee Stability in Elite Field Hockey Depends on Playing Class and Gender
Functional Knee Stability in Elite Field Hockey Depends on Playing Class and Gender Open
Field hockey, a physically demanding Olympic sport, carries a high risk of lower limb injuries, yet data on injury risk in elite field hockey are limited. Functional knee stability is important for injury prevention and a safe return to sp…
View article: Differences in the Synovial Fluid Proteome of Septic and Aseptic Implant Failure
Differences in the Synovial Fluid Proteome of Septic and Aseptic Implant Failure Open
Implant loosening is a severe complication after total joint replacement. Here, differential diagnosis between septic and aseptic cases is crucial for further surgical treatment, but low-grade periprosthetic joint infections (PJIs) in part…
View article: Surgical Site-Released Tissue Is Potent to Generate Bone onto TCP and PCL-TCP Scaffolds In Vitro
Surgical Site-Released Tissue Is Potent to Generate Bone onto TCP and PCL-TCP Scaffolds In Vitro Open
There is evidence that surgical site tissue (SSRT) released during orthopedic surgery has a strong mesenchymal regenerative potential. Some data also suggest that this tissue may activate synthetic or natural bone substitute materials and …
View article: 1st EFORT European Consensus “Medical & Scientific Research Requirements for the Clinical Introduction of Artificial Joint Arthroplasty Devices”: Background, Delphi Methodology & Consensus process
1st EFORT European Consensus “Medical & Scientific Research Requirements for the Clinical Introduction of Artificial Joint Arthroplasty Devices”: Background, Delphi Methodology & Consensus process Open
The objectives of the 1st EFORT European Consensus on ‘Medical and Scientific Research Requirements for the Clinical Introduction of Artificial Joint Arthroplasty Devices’ were foremost to focus on patient safety by establishing performanc…
View article: Introduction of innovations in joint arthroplasty: Recommendations from the ‘EFORT implant and patient safety initiative’
Introduction of innovations in joint arthroplasty: Recommendations from the ‘EFORT implant and patient safety initiative’ Open
With the implementation of the new MDR 2017/745 by the European Parliament, more robust clinical and pre-clinical data will be required due to a more stringent approval process. The EFORT Implant and Patient Safety Initiative WG1 ‘Introduc…
View article: Acute traumatic patellar tendon rupture and simultaneous fracture of the tibial tubercle avulsion in a premature soccer player
Acute traumatic patellar tendon rupture and simultaneous fracture of the tibial tubercle avulsion in a premature soccer player Open
Bone-tendon junctions are prone for acute trauma due to its structural weakness, especially in premature males. For the lower limb, the most eminent area is the tibial tubercle apophysis. Osgood Schlatter disease (OSD) due to repetitive tr…
View article: Do we still need to screen our patients?—Orthopaedic scoring based on motion tracking
Do we still need to screen our patients?—Orthopaedic scoring based on motion tracking Open
View article: Rechtliche Probleme für in Forschung und Entwicklung sowie im Healthcare- und Life-Science-Sektor verwendete Konservierungsmittel unter der europäischen Biozidverordnung
Rechtliche Probleme für in Forschung und Entwicklung sowie im Healthcare- und Life-Science-Sektor verwendete Konservierungsmittel unter der europäischen Biozidverordnung Open
Die gegenwärtige regulatorische Praxis der Biozidverordnung zeigt erhebliche Unzulänglichkeiten. Die Situation ist geprägt durch zu lange Verfahren, Unsicherheiten und durch eine ständige Anpassung der Anforderungen, die zu immer neuen Kos…
View article: Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange
Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange Open
Transthyretin (TTR) dissociation is the rate limiting step for both aggregation and subunit exchange. Kinetic stabilisers, small molecules that bind to the native tetrameric structure of TTR, slow TTR dissociation and inhibit aggregation. …
View article: SuperPath® vs. direct anterior approach
SuperPath® vs. direct anterior approach Open
View article: Influence of a Calcium Phosphate Coating (BONIT®) on the Proliferation and Differentiation Potential of Human Mesenchymal Stroma Cells in the Early Phase of Bone Healing
Influence of a Calcium Phosphate Coating (BONIT®) on the Proliferation and Differentiation Potential of Human Mesenchymal Stroma Cells in the Early Phase of Bone Healing Open
When implanting osteosynthetic materials or orthopedic implants, the surface condition plays a decisive role for mid- to long-term osseointegration. BONIT®, an electrochemically produced calcium phosphate (CaP) coating, has been used in th…
View article: Osteonekrosen – unheilbar?
Osteonekrosen – unheilbar? Open
View article: Measures of Knee Capability in Handball Players Differ by Age: A Cross Sectional Study
Measures of Knee Capability in Handball Players Differ by Age: A Cross Sectional Study Open
The return to sport after knee injury is challenging. This is burdensome for sports with a high incidence of injuries, such as team handball. Various tests guide decision making, but often the athlete’s preinjury performance of these measu…
View article: Metal Artefact Reduction Sequences (MARS) in Magnetic Resonance Imaging (MRI) after Total Hip Arthroplasty (THA)
Metal Artefact Reduction Sequences (MARS) in Magnetic Resonance Imaging (MRI) after Total Hip Arthroplasty (THA) Open
Background In the past, radiographic imaging was of minor relevance in the diagnosis of periprosthetic joint infections (PJI). Since metal artefact reduction sequences (MARS) are available, magnetic resonance imaging (MRI) has become a pro…
View article: The Implant Proteome—The Right Surgical Glue to Fix Titanium Implants In Situ
The Implant Proteome—The Right Surgical Glue to Fix Titanium Implants In Situ Open
Titanium implants are frequently applied to the bone in orthopedic and trauma surgery. Although these biomaterials are characterized by excellent implant survivorship and clinical outcomes, there are almost no data available on the initial…
View article: Cup positioning and its effect on polyethylene wear of vitamin E- and non-vitamin E-supplemented liners in total hip arthroplasty: radiographic outcome at 5-year follow-up
Cup positioning and its effect on polyethylene wear of vitamin E- and non-vitamin E-supplemented liners in total hip arthroplasty: radiographic outcome at 5-year follow-up Open
Background Aseptic loosening remains a challenging problem after total hip arthroplasty. Accurate cup placement and supplementation of antioxidants in acetabular liners might reduce material failure rates. The aim of this study is to asses…
View article: Metal Artefact Reduction Sequences (MARS) in Magnetic Resonance Imaging (MRI) After Total Hip Arthroplasty (THA). A Non-Invasive Approach for Preoperative Differentiation Between Periprosthetic Joint Infection (PJI) and Aseptic Complications?
Metal Artefact Reduction Sequences (MARS) in Magnetic Resonance Imaging (MRI) After Total Hip Arthroplasty (THA). A Non-Invasive Approach for Preoperative Differentiation Between Periprosthetic Joint Infection (PJI) and Aseptic Complications? Open
Background: In the past, radiographic imaging was of minor relevance in the diagnosis of periprosthetic joint infections (PJI). Since metal artefact reduction sequences (MARS) are available, magnetic resonance imaging (MRI) has become a pr…
View article: Major Surgical Trauma Impairs the Function of Natural Killer Cells but Does Not Affect Monocyte Cytokine Synthesis
Major Surgical Trauma Impairs the Function of Natural Killer Cells but Does Not Affect Monocyte Cytokine Synthesis Open
Major traumatic and surgical injury increase the risk for infectious complications due to immune dysregulation. Upon stimulation with interleukin (IL) 12 by monocyte/macrophages, natural killer (NK) cells release interferon (IFN) γ that su…
View article: A Retrospective Single-Center Study of 23 Patients to Compare Gait Before and After Total Hip Arthroplasty Using the S-ROM Modular Hip System
A Retrospective Single-Center Study of 23 Patients to Compare Gait Before and After Total Hip Arthroplasty Using the S-ROM Modular Hip System Open
BACKGROUND This retrospective study used the Harris hip score (HHS) and range of motion (ROM) to compare gait before and after total hip arthroplasty using the modular S-ROM® hip prosthesis in 23 patients treated at a single center. MATERI…
View article: Does Needle Design Affect the Regenerative Potential of Bone Marrow Aspirate? An In Vitro Study
Does Needle Design Affect the Regenerative Potential of Bone Marrow Aspirate? An In Vitro Study Open
While autologous bone is still the gold standard for treatment of bone defects, its availability is limited. Sufficient numbers of mesenchymal stroma cells (MSC) may be an alternative. Small volumes of bone marrow aspirate (BMA) were harve…
View article: Functionalization of Synthetic Bone Substitutes
Functionalization of Synthetic Bone Substitutes Open
Bone substitutes have been applied to treat osseous defects for a long time. To prevent implant related infection (IRI) and enhance bone healing functionalized biomaterials, antibiotics and osteoinductive substances have been introduced. T…
View article: A bicentric approach evaluating the combination of a hemispheric cup with a novel ceramic head in total hip arthroplasty
A bicentric approach evaluating the combination of a hemispheric cup with a novel ceramic head in total hip arthroplasty Open
Medical ceramics are frequently used biomaterials as a liner in total hip arthroplasty. Strong efforts have been made to improve material properties over the last decades. Alumina toughened zirconia ceramics seem to be promising alternativ…