Markus Joppich
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View article: Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolution
Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolution Open
Thrombotic diseases remain the major cause of death and disability worldwide, and the contribution of inflammation is increasingly recognized. Thromboinflammation has been identified as a key pathomechanism, but an unsupervised map of immu…
View article: PLO(SC)<sup>2</sup>: Plots and Scripts for scRNA-seq analysis
PLO(SC)<sup>2</sup>: Plots and Scripts for scRNA-seq analysis Open
Background scRNA-seq analysis has become a standard technique for studying biological systems. As costs decrease, scRNA-seq experiments become increasingly complex. While typical scRNA-seq analysis frameworks provide basic functionality to…
View article: Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis
Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis Open
Original Data for the manuscript: Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolution The manuscript is accessible at https://doi.org/10.1016/j.immuni.20…
View article: PICASO: Profiling Integrative Communities of Aggregated Single-cell Omics data
PICASO: Profiling Integrative Communities of Aggregated Single-cell Omics data Open
Various single-cell modalities covering transcriptomics, epigenetic and spatio-temporal changes in health and disease phenotypes are used in an exploratory way to understand biological systems at single-cell resolution. However, the vast a…
View article: Author response: Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia
Author response: Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia Open
View article: Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia
Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia Open
Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemi…
View article: Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes
Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes Open
Acute and chronic coronary syndromes (ACS and CCS) are leading causes of mortality. Inflammation is considered a key pathogenic driver of these diseases, but the underlying immune states and their clinical implications remain poorly unders…
View article: Peripheral priming induces plastic transcriptomic and proteomic responses in circulating neutrophils required for pathogen containment
Peripheral priming induces plastic transcriptomic and proteomic responses in circulating neutrophils required for pathogen containment Open
Neutrophils rapidly respond to inflammation and infection, but to which degree their functional trajectories after mobilization from the bone marrow are shaped within the circulation remains vague. Experimental limitations have so far hamp…
View article: Reviewer #2 (Public Review): Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia
Reviewer #2 (Public Review): Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia Open
Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemi…
View article: Reviewer #1 (Public Review): Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia
Reviewer #1 (Public Review): Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia Open
Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemi…
View article: Author Response: Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia
Author Response: Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia Open
Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemi…
View article: Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia
Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia Open
Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemi…
View article: Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia
Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia Open
Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemi…
View article: Author Response: Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia
Author Response: Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia Open
Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemi…
View article: Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis
Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis Open
Thrombotic diseases remain the major cause of death and disability worldwide with insufficient preventive and therapeutic strategies available. In the last decades a prominent inflammatory component has been identified as a key driver in t…
View article: Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis
Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis Open
<div>\n<h2>Original Data for the manuscript:</h2>\n<h2>Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis</h2>\n</div>\n<div>The manuscript is access…
View article: A single-cell atlas of immune checkpoint molecules in atherosclerosis in ApoE-/- mice
A single-cell atlas of immune checkpoint molecules in atherosclerosis in ApoE-/- mice Open
Introduction Immune checkpoint (IC) targeting is an attractive way to combat atherosclerosis, since ICs regulate the immune response by activating or inhibiting inflammatory pathways. We have shown that ICs exert cell-divergent functions a…
View article: Mural cells sustain a homeostatic vascular macrophage niche limiting chronic inflammation
Mural cells sustain a homeostatic vascular macrophage niche limiting chronic inflammation Open
If you use any of these data, please cite the corresponding publication:Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammationPekayvaz et al., Immunity, 2023 . ( https://do…
View article: Mural cells sustain a homeostatic vascular macrophage niche limiting chronic inflammation
Mural cells sustain a homeostatic vascular macrophage niche limiting chronic inflammation Open
If you use any of these data, please cite the corresponding publication: Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammationPekayvaz et al., Immunity, 2023 . ( https://d…
View article: Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation
Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation Open
Maladaptive, non-resolving inflammation contributes to chronic inflammatory diseases such as atherosclerosis. Because macrophages remove necrotic cells, defective macrophage programs can promote chronic inflammation with persistent tissue …
View article: PLO(SC)²: Plots and Scripts for scRNA-seq analysis
PLO(SC)²: Plots and Scripts for scRNA-seq analysis Open
Availability The PLOSC-project is available from https://github.com/mjoppich/PLOSC . The sequencing data (h5-files) were taken from: Pekayvaz K, Leunig A, Kaiser R, Joppich M, Brambs S, Janjic A, et al. Protective immune t…
View article: PLO(SC)²: Plots and Scripts for scRNA-seq analysis
PLO(SC)²: Plots and Scripts for scRNA-seq analysis Open
Availability The PLOSC-project is available from https://github.com/mjoppich/PLOSC . The sequencing data (h5-files) were taken from: Pekayvaz K, Leunig A, Kaiser R, Joppich M, Brambs S, Janjic A, et al. Protective immune t…
View article: Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia
Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia Open
Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemi…
View article: Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia
Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia Open
Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemi…
View article: Mural cells sustain a homeostatic vascular macrophage niche limiting chronic inflammation
Mural cells sustain a homeostatic vascular macrophage niche limiting chronic inflammation Open
If you use any of these data, please cite the corresponding publication: Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation Pekayvaz et al., Immunity, 2023 . ( https://…
View article: Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia
Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia Open
Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemi…
View article: Multi-Omic Factor Analysis uncovers immunological signatures with pathophysiologic and clinical implications in coronary syndromes
Multi-Omic Factor Analysis uncovers immunological signatures with pathophysiologic and clinical implications in coronary syndromes Open
Acute and chronic coronary syndromes (ACS and CCS) are leading causes of mortality. Inflammation is considered to be a key pathogenic driver, but immune states in humans and their clinical implications remain poorly understood. We hypothes…
View article: Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection Open
View article: Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection Open
scRNA-seq data Data were processed using cellranger v 4.0.0 with the refdata-gex-GRCh38-2020-A reference. h5files.zip: contains all h5-Files of raw feature-barcode counts (e.g. 20094_0001_A_B_raw_feature_bc_matrix…
View article: Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection Open
scRNA-seq data Data were processed using cellranger v 4.0.0 with the refdata-gex-GRCh38-2020-A reference. h5files.zip: contains all h5-Files of raw feature-barcode counts (e.g. 20094_0001_A_B_raw_feature_bc_matrix…