Markus Krämer
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View article: Correction to “Little MAO: Isolation of an {Al<sub>4</sub>} Methylalumoxane Species from the Reaction of Trimethylaluminum with Water”
Correction to “Little MAO: Isolation of an {Al<sub>4</sub>} Methylalumoxane Species from the Reaction of Trimethylaluminum with Water” Open
[This corrects the article DOI: 10.1021/acs.organomet.5c00195.].
View article: Anti-biofilm peptides can rescue fluconazole and amphotericin B efficacies against Candida albicans
Anti-biofilm peptides can rescue fluconazole and amphotericin B efficacies against Candida albicans Open
View article: Little MAO: Isolation of an {Al<sub>4</sub>} Methylalumoxane Species from the Reaction of Trimethylaluminum with Water
Little MAO: Isolation of an {Al<sub>4</sub>} Methylalumoxane Species from the Reaction of Trimethylaluminum with Water Open
View article: The Invertebrate-Derived Antimicrobial Peptide Cm-p5 Induces Cell Death and ROS Production in Melanoma Cells
The Invertebrate-Derived Antimicrobial Peptide Cm-p5 Induces Cell Death and ROS Production in Melanoma Cells Open
Nowadays, healthcare systems face two global challenges: the rise of multidrug-resistant pathogens and the growing incidence of cancer. Due to their broad spectrum of activities, antimicrobial peptides emerged as potential alternatives aga…
View article: Understanding partitioning in two-phase systems with induced miscibility gaps—comparing SWIEET and QuEChERS
Understanding partitioning in two-phase systems with induced miscibility gaps—comparing SWIEET and QuEChERS Open
View article: Salamandamide Lipodipeptides Are Biosynthetic Intermediate Shunt Products of the Nonamodular Nonribosomal Peptide Assembly Lines of the Viscosin Family
Salamandamide Lipodipeptides Are Biosynthetic Intermediate Shunt Products of the Nonamodular Nonribosomal Peptide Assembly Lines of the Viscosin Family Open
Chemical investigation of a salamander-mucus-associated Pseudomonas tolaasii strain led to the isolation and chemical characterization of salamandamide A, a new lipo-dipeptide, along with known lipopeptides of the pseudodesmin and t…
View article: Grazing incidence and grazing exit X-ray fluorescence: principles, techniques, and applications for thin film and nanostructure analysis
Grazing incidence and grazing exit X-ray fluorescence: principles, techniques, and applications for thin film and nanostructure analysis Open
The grazing incidence – and grazing exit X-ray fluorescence techniques and their theoretical background are described with examples and a review of recent developments and applications is provided in this review.
View article: Triphenyl‐Modified Mixed‐Mode Stationary Phases With and Without Embedded Ion‐Exchange Sites for High‐Performance Liquid Chromatography
Triphenyl‐Modified Mixed‐Mode Stationary Phases With and Without Embedded Ion‐Exchange Sites for High‐Performance Liquid Chromatography Open
The present work reports on the preparation, characterization, and evaluation of a set of novel triphenyl‐modified silica‐based stationary phases without and with embedded ion‐exchange sites for mixed‐mode liquid chromatography. The three …
View article: Inverse-Nanoemulsion-Derived Protein Hydrogels (NanoTrans-Gels) Can Outperform DOSPA/DOPE Lipid-Complex Transfection Agent
Inverse-Nanoemulsion-Derived Protein Hydrogels (NanoTrans-Gels) Can Outperform DOSPA/DOPE Lipid-Complex Transfection Agent Open
Transfection of mammalian and human cell lines in medical research both are key technologies in molecular biology and genetic engineering. A vast variety of techniques to facilitate transfection exists including different chemical and nano…
View article: Wide-pore fully porous mixed-mode octyl/pyridyl-bonded silica material with pH-dependent surface charge reversal for high-performance hydrophobic charge-induction chromatography of proteins
Wide-pore fully porous mixed-mode octyl/pyridyl-bonded silica material with pH-dependent surface charge reversal for high-performance hydrophobic charge-induction chromatography of proteins Open
In an attempt to overcome silanophilic interactions like observed on popular reversed-phase butyl‑bonded silica stationary phases in protein HPLC, a mixed-mode stationary phase based on wide pore silica (3 µm, 300 Å) was prepared by co-imm…
View article: Anti-biofilm peptides can rescue fluconazole and amphotericin B efficacies against Candida albicans
Anti-biofilm peptides can rescue fluconazole and amphotericin B efficacies against Candida albicans Open
Candida albicans infections are a global health thread and challenge healthcare environments due to acquired resistances against prominent antifungals like amphotericin B and fluconazole, which additionally have severe adverse effects. The…
View article: IMPATIENT-qPCR: monitoring SELEX success during in vitro aptamer evolution
IMPATIENT-qPCR: monitoring SELEX success during in vitro aptamer evolution Open
SELEX (Systematic Evolution of Ligands by Exponential enrichment) processes aim on the evolution of high-affinity aptamers as binding entities in diagnostics and biosensing. Aptamers can represent game-changers as constituents of diagnosti…
View article: Robust Fluorometric Aptamer Assay for Direct and Rapid Detection of Clinical Isolates of Candida spec.
Robust Fluorometric Aptamer Assay for Direct and Rapid Detection of Clinical Isolates of Candida spec. Open
Infections caused by yeasts of the genus Candida are likely to occur not only in immunocompromised patients but also in healthy individuals, leading to infections of the gastrointestinal tract, urinary tract, and respiratory tract. Due to …
View article: Recombinant Production of Pseudomonas aeruginosa Rhamnolipids in P. putida KT2440 on Acetobacterium woodii Cultures Grown Chemo-Autotrophically with Carbon Dioxide and Hydrogen
Recombinant Production of Pseudomonas aeruginosa Rhamnolipids in P. putida KT2440 on Acetobacterium woodii Cultures Grown Chemo-Autotrophically with Carbon Dioxide and Hydrogen Open
The establishment of sustainable processes for the production of commodity chemicals is one of today’s central challenges for biotechnological industries. The chemo-autotrophic fixation of CO2 and the subsequent production of acetate by ac…
View article: The Designed Pore-Forming Antimicrobial Peptide C14R Combines Excellent Activity against the Major Opportunistic Human Pathogen Pseudomonas aeruginosa with Low Cytotoxicity
The Designed Pore-Forming Antimicrobial Peptide C14R Combines Excellent Activity against the Major Opportunistic Human Pathogen Pseudomonas aeruginosa with Low Cytotoxicity Open
The diminishing portfolio of mankind’s available antibiotics urges science to develop novel potent drugs. Here, we present a peptide fitting the typical blueprint of amphipathic and membrane-active antimicrobial peptides, denominated C14R.…
View article: IMPATIENT-qPCR: melting-temperature-shift based evolution monitoring of successful aptamer development in SELEX processes
IMPATIENT-qPCR: melting-temperature-shift based evolution monitoring of successful aptamer development in SELEX processes Open
SELEX (Systematic Evolution of Ligands by Exponential enrichment) processes aim on the evolution of high affinity aptamers as binding entities in diagnostics and biosensing. Aptamers can represent game-changers as constituents of diagnosti…
View article: Enriched Aptamer Libraries in Fluorescence-Based Assays for Rikenella microfusus-Specific Gut Microbiome Analyses
Enriched Aptamer Libraries in Fluorescence-Based Assays for Rikenella microfusus-Specific Gut Microbiome Analyses Open
Rikenella microfusus is an essential intestinal probiotic with great potential. The latest research shows that imbalance in the intestinal flora are related to the occurrence of various diseases, such as intestinal diseases, immune disease…
View article: Principles and Applications of CF<sub>2</sub>X Moieties as Unconventional Halogen Bond Donors in Medicinal Chemistry, Chemical Biology, and Drug Discovery
Principles and Applications of CF<sub>2</sub>X Moieties as Unconventional Halogen Bond Donors in Medicinal Chemistry, Chemical Biology, and Drug Discovery Open
As an orthogonal principle to the established (hetero)aryl halides, we herein highlight the usefulness of CF2X (X = Cl, Br, or I) moieties. Using tool compounds bearing CF2X moieties, we study their chemical/metabolic…
View article: CCDC 2157628: Experimental Crystal Structure Determination
CCDC 2157628: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2157626: Experimental Crystal Structure Determination
CCDC 2157626: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2157627: Experimental Crystal Structure Determination
CCDC 2157627: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Bioinformatics-Guided Discovery of Biaryl-Tailored Lasso Peptides
Bioinformatics-Guided Discovery of Biaryl-Tailored Lasso Peptides Open
Lasso peptides are a class of ribosomally synthesized and post-translationally modified peptides (RiPPs) that feature an isopeptide bond and a distinct lariat fold. A growing number of secondary modifications have been described that furth…
View article: Bioinformatics-guided discovery of biaryl-linked lasso peptides
Bioinformatics-guided discovery of biaryl-linked lasso peptides Open
Genome mining enabled the discovery of a series of unique lasso peptides. They contain a P450-mediated C–N-based biarylic crosslink at the lasso ring and can in addition bear a unique sulfonium residue.
View article: Screening of a Halogen-Enriched Fragment Library Leads to Unconventional Binding Modes
Screening of a Halogen-Enriched Fragment Library Leads to Unconventional Binding Modes Open
We conceived the Halogen-Enriched Fragment Library (HEFLib) to investigate the potential of halogen bonds in the early stages of drug discovery. As the number of competitive interactions increases with ligand size, we reasoned that a bindi…
View article: Polyclonal Aptamer Libraries from a FluRoot-SELEX for the Specific Labeling of the Apical and Elongation/Differentiation Zones of Arabidopsis thaliana Roots
Polyclonal Aptamer Libraries from a FluRoot-SELEX for the Specific Labeling of the Apical and Elongation/Differentiation Zones of Arabidopsis thaliana Roots Open
In more than 30 years of aptamer research, it has become widely accepted that aptamers are fascinating binding molecules for a vast variety of applications. However, the majority of targets have been proteins, although special variants of …
View article: Experimental and theoretical approaches for determining the K-shell fluorescence yield of carbon
Experimental and theoretical approaches for determining the K-shell fluorescence yield of carbon Open
View article: A Polyclonal Selex Aptamer Library Directly Allows Specific Labelling of the Human Gut Bacterium Blautia producta without Isolating Individual Aptamers
A Polyclonal Selex Aptamer Library Directly Allows Specific Labelling of the Human Gut Bacterium Blautia producta without Isolating Individual Aptamers Open
Recent studies have demonstrated that changes in the abundance of the intestinal bacterium Blautia producta, a potential probiotic, are closely associated with the development of various diseases such as obesity, diabetes, some neurodegene…
View article: A Polyclonal SELEX Aptamer Library Allows Differentiation of Candida albicans, C. auris and C. parapsilosis Cells from Human Dermal Fibroblasts
A Polyclonal SELEX Aptamer Library Allows Differentiation of Candida albicans, C. auris and C. parapsilosis Cells from Human Dermal Fibroblasts Open
Easy and reliable identification of pathogenic species such as yeasts, emerging as problematic microbes originating from the genus Candida, is a task in the management and treatment of infections, especially in hospitals and other healthca…
View article: A Polyclonal Aptamer Library for the Specific Binding of the Gut Bacterium Roseburia intestinalis in Mixtures with Other Gut Microbiome Bacteria and Human Stool Samples
A Polyclonal Aptamer Library for the Specific Binding of the Gut Bacterium Roseburia intestinalis in Mixtures with Other Gut Microbiome Bacteria and Human Stool Samples Open
Roseburia intestinalis has received attention as a potential probiotic bacterium. Recent studies have demonstrated that changes in its intestinal abundance can cause various diseases, such as obesity, enteritis and atherosclerosis. Probiot…
View article: [(CH<sub>3</sub>)Al(CH<sub>2</sub>)]<sub>12</sub>: Methylaluminomethylene (MAM‐12)
[(CH<sub>3</sub>)Al(CH<sub>2</sub>)]<sub>12</sub>: Methylaluminomethylene (MAM‐12) Open
The molecular structure of enigmatic “poly(aluminium‐methyl‐methylene)” (first reported in 1968) has been unraveled in a transmetalation reaction with gallium methylene [Ga 8 (CH 2 ) 12 ] and AlMe 3 . The existence of cage‐like methylalumi…