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View article: Highly Loaded Reactive Oxygen Species–Responsive Theranostic Lenvatinib‐Prodrug Nanoparticles Produced by Dispersion Polymerization
Highly Loaded Reactive Oxygen Species–Responsive Theranostic Lenvatinib‐Prodrug Nanoparticles Produced by Dispersion Polymerization Open
Nanoparticles represent a powerful class of materials for drug delivery, leveraging their small size for passive targeting through the enhanced permeability and retention effect in tumors. This universal approach in tumor targeting offers …
View article: Oligoethylene Phosphoramidate‐Based Kinase Inhibitor Prodrugs – Solubility, Enzyme Inhibition, and Hydrolysis
Oligoethylene Phosphoramidate‐Based Kinase Inhibitor Prodrugs – Solubility, Enzyme Inhibition, and Hydrolysis Open
The efficiency of kinase inhibiting cancer therapeutics is often limited by their poor solubility in water. PEGylation is one possible strategy to improve the solubility of the drug, however, means to cleave off the PEG after reaching the …
View article: Highly Loaded ROS-Responsive Theranostic Lenvatinib-Prodrug Nanoparticles Produced by Dispersion Polymerization
Highly Loaded ROS-Responsive Theranostic Lenvatinib-Prodrug Nanoparticles Produced by Dispersion Polymerization Open
Nanoparticles represent a powerful class of materials for drug delivery, leveraging their small size for passive targeting through the enhanced permeation and retention (EPR) effect in tumors. This universal approach in tumor targeting off…
View article: Highly Loaded ROS-Responsive Theranostic Lenvatinib-Prodrug Nanoparticles Produced by Dispersion Polymerization
Highly Loaded ROS-Responsive Theranostic Lenvatinib-Prodrug Nanoparticles Produced by Dispersion Polymerization Open
Nanoparticles represent a powerful class of materials for drug delivery, leveraging their small size for passive targeting through the enhanced permeation and retention (EPR) effect in tumors. This universal approach in tumor targeting off…
View article: A Phosphoramidate Prodrug Platform: One‐Pot Amine Functionalization of Kinase Inhibitors with Oligoethylene Glycol for Improved Water‐Solubility
A Phosphoramidate Prodrug Platform: One‐Pot Amine Functionalization of Kinase Inhibitors with Oligoethylene Glycol for Improved Water‐Solubility Open
Small molecular kinase inhibitors play a key role in modern cancer therapy. Protein kinases are essential mediators in the growth and progression of cancerous tumors, rendering involved kinases an increasingly important target for therapy.…
View article: Water-Soluble Trityl Radicals for Fluorescence Imaging
Water-Soluble Trityl Radicals for Fluorescence Imaging Open
Stable tris(trichlorophenyl)methyl radicals have gained interest as all-organic bioimaging agents combining fluorescent and paramagnetic properties. However, cellular uptake has so far only been reported for nanoparticles, because molecula…
View article: Red-Fluorescing Paramagnetic Conjugated Polymer Nanoparticles – Triphenyl Methyl Radicals as Monomers in C-C Cross-Coupling Dispersion Polymerization
Red-Fluorescing Paramagnetic Conjugated Polymer Nanoparticles – Triphenyl Methyl Radicals as Monomers in C-C Cross-Coupling Dispersion Polymerization Open
We report the synthesis of conjugated polymer nanoparticles carrying stable luminescent radical units. These monodisperse conjugated radical nanoparticles can be tuned in their diameter over several hundred nanometers. They are stable in a…
View article: Red-Fluorescing Paramagnetic Conjugated Polymer Nanoparticles – Triphenyl Methyl Radicals as Monomers in C-C Cross-Coupling Dispersion Polymerization
Red-Fluorescing Paramagnetic Conjugated Polymer Nanoparticles – Triphenyl Methyl Radicals as Monomers in C-C Cross-Coupling Dispersion Polymerization Open
We report the synthesis of conjugated polymer nanoparticles carrying stable luminescent radical units. These monodisperse conjugated radical nanoparticles can be tuned in their diameter over several hundred nanometers. They are stable in a…
View article: Biodegradable Polyimidazole Particles as Contrast Agents produced by Direct Arylation Polymerization
Biodegradable Polyimidazole Particles as Contrast Agents produced by Direct Arylation Polymerization Open
Conjugated polymer particles provide an important platform for the development of theranostic nanoagents. However, the number of biocompatible and foremost biodegradable π-conjugated polymers is limited. Imidazole is a π-conjugated motif t…
View article: Biodegradable Polyimidazole Particles as Contrast Agents produced by Direct Arylation Polymerization
Biodegradable Polyimidazole Particles as Contrast Agents produced by Direct Arylation Polymerization Open
Conjugated polymer particles provide an important platform for the development of theranostic nanoagents. However, the number of biocompatible and foremost biodegradable π-conjugated polymers is limited. Imidazole is a π-conjugated motif t…
View article: Narrow Stimulated Resonance Raman Scattering and WGM Lasing in Small Conjugated Polymer Particles for Live Cell Tagging and Tracking
Narrow Stimulated Resonance Raman Scattering and WGM Lasing in Small Conjugated Polymer Particles for Live Cell Tagging and Tracking Open
Conjugated polymer particles are brightly fluorescing and stable materials for live cell imaging. Combination of conjugated polymers with a whispering gallery mode (WGM) resonator allows laser emission from microscale particles. Once inter…
View article: Croconaine‐Based Polymer Particles as Contrast Agents for Photoacoustic Imaging
Croconaine‐Based Polymer Particles as Contrast Agents for Photoacoustic Imaging Open
In the development and optimization of imaging methods, photoacoustic imaging (PAI) has become a powerful tool for preclinical biomedical diagnosis and detection of cancer. PAI probes can improve contrast and help identify pathogenic tissu…
View article: Chemoselective Dual Labeling of Native and Recombinant Proteins
Chemoselective Dual Labeling of Native and Recombinant Proteins Open
The attachment of two different functionalities in a site-selective fashion represents a great challenge in protein chemistry. We report site specific dual functionalizations of peptides and proteins capitalizing on reactivity differences …
View article: Generation and Characterization of Virus-Enhancing Peptide Nanofibrils Functionalized with Fluorescent Labels
Generation and Characterization of Virus-Enhancing Peptide Nanofibrils Functionalized with Fluorescent Labels Open
Retroviral gene transfer is the method of choice for the stable introduction of genetic material into the cellular genome. However, efficient gene transfer is often limited by low transduction rates of the viral vectors. We have recently d…
View article: Water-soluble allyl sulfones for dual site-specific labelling of proteins and cyclic peptides
Water-soluble allyl sulfones for dual site-specific labelling of proteins and cyclic peptides Open
Allyl sulfones as efficient disulfide rebridging agents for site-specific protein modifications with up to two additional functionalities in water.