Markus Mandler
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View article: WISIT vaccines based on IL-31-derived peptides as a novel therapeutic approach for chronic pruritic dermatoses
WISIT vaccines based on IL-31-derived peptides as a novel therapeutic approach for chronic pruritic dermatoses Open
Vaccines are a promising therapy for the treatment of chronic conditions such as pruritus. IL-31 has been identified as an important mediator of itch. By targeting IL-31 signaling with immunotherapy, CP can be effectively alleviated. Howev…
View article: Effective vaccines for non-communicable diseases - A pipe dream?
Effective vaccines for non-communicable diseases - A pipe dream? Open
Effective vaccines for non-communicable diseases - A pipe dream? Markus Mandler, Founder and CEO of Tridem Bioscience, explains how the company’s cutting-edge vaccine platform is revolutionising treatment approaches and vaccines for non-co…
View article: Improved tropoelastin synthesis in the skin by codon optimization and nucleotide modification of tropoelastin-encoding synthetic mRNA
Improved tropoelastin synthesis in the skin by codon optimization and nucleotide modification of tropoelastin-encoding synthetic mRNA Open
Loss of elastin due to aging, disease, or injury can lead to impaired tissue function. In this study, de novo tropoelastin (TE) synthesis is investigated in vitro and in vivo using different TE-encoding synthetic mRNA variants after codon …
View article: A Novel C-Type Lectin Receptor-Targeted α-Synuclein-Based Parkinson Vaccine Induces Potent Immune Responses and Therapeutic Efficacy in Mice
A Novel C-Type Lectin Receptor-Targeted α-Synuclein-Based Parkinson Vaccine Induces Potent Immune Responses and Therapeutic Efficacy in Mice Open
The progressive accumulation of misfolded α-synuclein (α-syn) in the brain is widely considered to be causal for the debilitating clinical manifestations of synucleinopathies including, most notably, Parkinson’s disease (PD). Immunotherapi…
View article: Effect of mRNA Delivery Modality and Formulation on Cutaneous mRNA Distribution and Downstream eGFP Expression
Effect of mRNA Delivery Modality and Formulation on Cutaneous mRNA Distribution and Downstream eGFP Expression Open
In vitro transcribed messenger ribonucleic acid (mRNA) constitutes an emerging therapeutic class with several clinical applications. This study presents a systematic comparison of different technologies—intradermal injection, microneedle i…
View article: Effects of single and combined immunotherapy approach targeting amyloid β protein and α‐synuclein in a dementia with Lewy bodies–like model
Effects of single and combined immunotherapy approach targeting amyloid β protein and α‐synuclein in a dementia with Lewy bodies–like model Open
Introduction Immunotherapeutic approaches targeting amyloid β (Aβ) protein and tau in Alzheimer's disease and α‐synuclein (α‐syn) in Parkinson's disease are being developed for treating dementia with Lewy bodies. However, it is unknown if …
View article: Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy
Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy Open
This study further validates the efficacy of vaccination with AFFITOPEs® for ameliorating the neurodegenerative pathology in synucleinopathies.
View article: Tailoring the Antibody Response to Aggregated Aß Using Novel Alzheimer-Vaccines
Tailoring the Antibody Response to Aggregated Aß Using Novel Alzheimer-Vaccines Open
Recent evidence suggests Alzheimer-Disease (AD) to be driven by aggregated Aß. Capitalizing on the mechanism of molecular mimicry and applying several selection layers, we screened peptide libraries for moieties inducing antibodies selecti…