Markus Pirklbauer
YOU?
Author Swipe
View article: Beta-2-Microglobulin Maintains Overall Survival Prediction in Binet A Stage Chronic Lymphocytic Leukemia Patients with Compromised Kidney Function in Both Treatment Eras of Chemoimmunotherapy and Targeted Agents
Beta-2-Microglobulin Maintains Overall Survival Prediction in Binet A Stage Chronic Lymphocytic Leukemia Patients with Compromised Kidney Function in Both Treatment Eras of Chemoimmunotherapy and Targeted Agents Open
Background: Elevated beta-2-microglobulin (B2M) plasma levels commonly imply a higher CLL-IPI risk category for short overall survival (OS), but the risk model was not adjusted for compromised kidney function and not validated in Binet A s…
View article: Patient and Caregiver Perspectives on Gender Disparity in CKD
Patient and Caregiver Perspectives on Gender Disparity in CKD Open
Key Points Women felt vulnerable and felt that their housework obligations may interfere with CKD treatment, especially dialysis. Women felt they were good at protecting their health, whereas men might expect help from others and live in d…
View article: Patient and Caregiver Perspectives on Gender Disparity in Chronic Kidney Disease: Questionnaire Survey, Based on an Interview Study
Patient and Caregiver Perspectives on Gender Disparity in Chronic Kidney Disease: Questionnaire Survey, Based on an Interview Study Open
Introduction: Chronic kidney disease (CKD) in stages 3–5 without albuminuria occurs more often in women than in men; however, most patients initiating and receiving kidney replacement therapy are men. Sex-determined biological factors and …
View article: Reduced prognostic value of beta-2-microglobulin for time to first treatment in CLL patients with compromised kidney function
Reduced prognostic value of beta-2-microglobulin for time to first treatment in CLL patients with compromised kidney function Open
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults and characterized by a highly heterogeneous clinical course. The CLL-IPI and the OCLL-1 scores are among the best validated tools to predict time-to-first-treatment. …
View article: Editorial: Insights in clinical research in nephrology
Editorial: Insights in clinical research in nephrology Open
Keywords: chronic kidney disease, prevention, missing heritability, advancing age, sodium intake, SIRI index, insulin
View article: Rationale and design of the Innsbruck Diabetic Kidney Disease Cohort (IDKDC)—a prospective study investigating etiology and progression of early-stage chronic kidney disease in type 2 diabetes
Rationale and design of the Innsbruck Diabetic Kidney Disease Cohort (IDKDC)—a prospective study investigating etiology and progression of early-stage chronic kidney disease in type 2 diabetes Open
Background The development of chronic kidney disease (CKD) in about 20%–40% of patients with type 2 diabetes (T2D) aggravates cardiovascular morbidity and mortality. Pathophysiology is of increasing relevance for individual management and …
View article: Renin–Angiotensin–Aldosterone System: From History to Practice of a Secular Topic
Renin–Angiotensin–Aldosterone System: From History to Practice of a Secular Topic Open
Renin–angiotensin–aldosterone system (RAAS) inhibitors are standard care in patients with hypertension, heart failure or chronic kidney disease (CKD). Although we have studied the RAAS for decades, there are still circumstances that remain…
View article: Perioperative and Long-Term Outcomes in Patients Undergoing Synchronous Carotid Endarterectomy and Coronary Artery Bypass Grafting: A Single-Center Experience
Perioperative and Long-Term Outcomes in Patients Undergoing Synchronous Carotid Endarterectomy and Coronary Artery Bypass Grafting: A Single-Center Experience Open
The above graphical abstract represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, and copyright information, please see the full text online. (see “read the peer-revi…
View article: Kalziumregulation aus nephrologischer Sicht – manches anders als gedacht?
Kalziumregulation aus nephrologischer Sicht – manches anders als gedacht? Open
Zusammenfassung Eine präzise Regulation der extrazellulären Kalziumkonzentration ist essenziell für das Funktionieren des Organismus. Parathormon und Vitamin D steuern und synchronisieren dosisabhängig die kalziumregulierenden Organsysteme…
View article: Advice and challenges in the pharmacotherapeutic management of diabetic kidney disease in adults
Advice and challenges in the pharmacotherapeutic management of diabetic kidney disease in adults Open
KEYWORDS: Diabetic kidney diseaseglucagon-like peptide-1 agonistsnon-steroidal mineralocorticoid receptor antagonistspharmacotherapyrenin–angiotensin system drug effectssodium-glucose transporter 2 inhibitors
View article: Editorial: Personalized medicine in CKD patients
Editorial: Personalized medicine in CKD patients Open
Chronic kidney disease (CKD) is a clinical condition associated with an increased risk for 12 cardiovascular (CV) events, all-cause mortality, and end-stage kidney disease (ESKD). Moreover, its 13 incidence and prevalence are rising dramat…
View article: Infection with SARS-CoV-2 Is Associated with Elevated Levels of IP-10, MCP-1, and IL-13 in Sepsis Patients
Infection with SARS-CoV-2 Is Associated with Elevated Levels of IP-10, MCP-1, and IL-13 in Sepsis Patients Open
Immunothrombosis, an excessive inflammatory response with simultaneous overactivation of the coagulation system, is a central pathomechanism in sepsis and COVID-19. It is associated with cellular activation, vascular damage, and microvascu…
View article: Dialysevorschrift
Dialysevorschrift Open
Zusammenfassung Hintergrund Empfehlungen für das intradialytische Elektrolytmanagement basieren derzeit ausschließlich auf Beobachtungsstudien, pathophysiologischen Überlegungen und Expertenmeinungen. Fragestellung Darstellung praxistaugli…
View article: Extremely severe hypochloremic metabolic alkalosis after ileorectal anastomosis in a patient with chronic intestinal pseudo-obstruction
Extremely severe hypochloremic metabolic alkalosis after ileorectal anastomosis in a patient with chronic intestinal pseudo-obstruction Open
View article: Population Characteristics and Clinical Outcomes from the Renal Transplant Outcome Prediction Validation Study (TOPVAS)
Population Characteristics and Clinical Outcomes from the Renal Transplant Outcome Prediction Validation Study (TOPVAS) Open
Kidney transplantation is the preferred method for selected patients with kidney failure. Despite major improvements over the last decades, a significant proportion of organs are still lost every year. Causes of graft loss and impaired gra…
View article: Humoral Immune Response to a Timely Booster mRNA Vaccination in Non-Responders to a Standard Vaccination Schedule against COVID-19 in Kidney Transplant Recipients
Humoral Immune Response to a Timely Booster mRNA Vaccination in Non-Responders to a Standard Vaccination Schedule against COVID-19 in Kidney Transplant Recipients Open
Kidney transplant recipients who are at increased risk for COVID-19 infection and associated morbidity and mortality have been shown to be prone to an impaired humoral immune response to a standard vaccination schedule against COVID-19 wit…
View article: Chronic kidney disease is more prevalent among women but more men than women are under nephrological care
Chronic kidney disease is more prevalent among women but more men than women are under nephrological care Open
View article: Mathematical Models of Parathyroid Gland Biology: Complexity and Clinical Use
Mathematical Models of Parathyroid Gland Biology: Complexity and Clinical Use Open
Altered parathyroid gland biology is a major driver of chronic kidney disease-mineral bone disorder (CKD-MBD) in patients with chronic kidney disease. CKD-MBD is associated with a high risk of vascular calcification and cardiovascular even…
View article: Hairy Cell Leukemia Patients Have a Normal Life Expectancy—A 35-Year Single-Center Experience and Comparison with the General Population
Hairy Cell Leukemia Patients Have a Normal Life Expectancy—A 35-Year Single-Center Experience and Comparison with the General Population Open
Classic hairy cell leukemia (HCL) is an uncommon hematologic malignancy characterized by an excellent prognosis since purine analogues (PA), such as cladribine (2-CdA), have been introduced in the 1990s. However, most data on long-term out…
View article: The Tangential Extraperitoneal Retrorenal Approach in Kidney Transplant Biopsy: An Observational Study to Assess Complication and Adequacy Rates
The Tangential Extraperitoneal Retrorenal Approach in Kidney Transplant Biopsy: An Observational Study to Assess Complication and Adequacy Rates Open
Introduction: Ultrasound-guided percutaneous kidney allograft biopsy is the gold-standard for pathology work-up. Recent studies postulate better safety and efficacy for tangential approaches, however, there is no recommendation regarding b…
View article: Antibody Response to mRNA Vaccines against SARS-CoV-2 with Chronic Kidney Disease, Hemodialysis, and after Kidney Transplantation
Antibody Response to mRNA Vaccines against SARS-CoV-2 with Chronic Kidney Disease, Hemodialysis, and after Kidney Transplantation Open
Most trials on mRNA vaccines against SARS-CoV-2 did not include patients with chronic kidney disease (CKD), hemodialysis (HD) patients, or kidney transplant recipients (KTR). However, those patients have a higher risk for a severe course o…
View article: Personalized Prediction of Short- and Long-Term PTH Changes in Maintenance Hemodialysis Patients
Personalized Prediction of Short- and Long-Term PTH Changes in Maintenance Hemodialysis Patients Open
Background: Personalized management of secondary hyperparathyroidism is a critical part of hemodialysis patient care. We used a mathematical model of parathyroid gland (PTG) biology to predict (1) short-term peridialytic intact PTH (iPTH) …
View article: Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial
Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial Open
View article: Empagliflozin Inhibits IL-1β-Mediated Inflammatory Response in Human Proximal Tubular Cells
Empagliflozin Inhibits IL-1β-Mediated Inflammatory Response in Human Proximal Tubular Cells Open
SGLT2 inhibitor-related nephroprotection is—at least partially—mediated by anti-inflammatory drug effects, as previously demonstrated in diabetic animal and human studies, as well as hyperglycemic cell culture models. We recently presented…
View article: Anti-inflammatory potential of Empagliflozin
Anti-inflammatory potential of Empagliflozin Open
A recent article by Maayah and coworkers elegantly described a survival benefit with the use of the SGLT2 inhibitor Empagliflozin (Empa) in a murine model of LPSinduced septic shock (Maayah et al. 2020).The authors present evidence that th…
View article: Empagliflozin Inhibits Basal and IL-1β-Mediated MCP-1/CCL2 and Endothelin-1 Expression in Human Proximal Tubular Cells
Empagliflozin Inhibits Basal and IL-1β-Mediated MCP-1/CCL2 and Endothelin-1 Expression in Human Proximal Tubular Cells Open
SGLT2 inhibitors (SGLT2i) slow the progression of chronic kidney disease; however, evidence for the underlying molecular mechanisms is scarce. We investigated SGLT2i-mediated effects on differential gene expression in two independent human…
View article: Hemodialysis treatment in patients with severe electrolyte disorders: Management of hyperkalemia and hyponatremia
Hemodialysis treatment in patients with severe electrolyte disorders: Management of hyperkalemia and hyponatremia Open
Significant deviations of serum potassium and sodium levels are frequently observed in hospitalized patients and are both associated with increased all‐cause and cardiovascular mortality. The presence of acute or chronic renal failure faci…
View article: Intradialytic Calcium Kinetics and Cardiovascular Disease in Chronic Hemodialysis Patients
Intradialytic Calcium Kinetics and Cardiovascular Disease in Chronic Hemodialysis Patients Open
Background/Objective: Calcium loading has been associated with cardiovascular risk in hemodialysis (HD) patients. However, it remains to be elucidated whether alterations of intradialytic calcium buffering add to the increase…
View article: Prophylactic Ligature of AV Fistula Prevents High Output Heart Failure after Kidney Transplantation
Prophylactic Ligature of AV Fistula Prevents High Output Heart Failure after Kidney Transplantation Open
Background: Arteriovenous (AV) fistulas are considered the gold standard for ensuring safe and long-term vascular access in patients with haemodialysis-dependent end-stage renal disease. However, previous studies demonstrated…
View article: Immunosuppression after renal transplantation
Immunosuppression after renal transplantation Open
Immunosuppression (IS) is administered to kidney transplant recipients to prevent rejection episodes and loss of the renal allograft. Most centers rely on a triple IS after induction with either interleukin‑2 receptor antibodies or antithy…