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View article: Two-Stage Hepatectomy for Cholangiocarcinoma Under Total Vascular Exclusion with Veno-venous ECMO Bypass and Controlled Closed-loop In Situ Hypothermic Oxygenated Perfusion of the Liver: The Hannover CLIP-Concept
Two-Stage Hepatectomy for Cholangiocarcinoma Under Total Vascular Exclusion with Veno-venous ECMO Bypass and Controlled Closed-loop In Situ Hypothermic Oxygenated Perfusion of the Liver: The Hannover CLIP-Concept Open
Background Total vascular exclusion (TVE) enables the resection of centrally located liver tumors but remains associated with considerable intra- and perioperative morbidity. We present the Hannover Modification of TVE, which combines veno…
View article: Posterior instrumented correction and fusion of Scheuermann´s results in physiological reconstruction of sagittal alignment and excellent overall clinical outcome- clinical trail of 73 patients
Posterior instrumented correction and fusion of Scheuermann´s results in physiological reconstruction of sagittal alignment and excellent overall clinical outcome- clinical trail of 73 patients Open
Purpose The aim was to assess the clinical outcomes after posterior spinal fusion (PSF) in patients with Scheuermann’s disease (SD). Methods SD undergoing PSF were retrospectively analyzed. Clinical outcome was determined using SRS-22- and…
View article: Is There a High Risk for GI Bleeding Complications in Patients Undergoing Abdominal Surgery?
Is There a High Risk for GI Bleeding Complications in Patients Undergoing Abdominal Surgery? Open
Introduction: Gastrointestinal bleeding (GIB) can cause life-threatening situations. Here, endoscopy is the first-line diagnostic and therapeutic mode in patients with GIB among further therapeutic approaches such as embolization or medica…
View article: Feasibility and Efficacy of Adjuvant Chemotherapy With Gemcitabine After Liver Transplantation for Perihilar Cholangiocarcinoma - A Multi-Center, Randomized, Controlled Trial (pro-duct001)
Feasibility and Efficacy of Adjuvant Chemotherapy With Gemcitabine After Liver Transplantation for Perihilar Cholangiocarcinoma - A Multi-Center, Randomized, Controlled Trial (pro-duct001) Open
Background Liver transplantation (LT) is considered a therapeutic option for unresectable perihilar cholangiocarcinoma (PHC) within defined criteria. It remains uncertain whether patients can safely receive adjuvant chemotherapy after LT. …
View article: How can postoperative shoulder imbalance be prevented in adolescent idiopathic scoliosis type 2?
How can postoperative shoulder imbalance be prevented in adolescent idiopathic scoliosis type 2? Open
Postoperative shoulder imbalance (PSI) is a common complication following adolescent idiopathic scolio- sis (AIS) surgery. There is little data available in literature on prediction of PSI. Prospectively collected data of AIS with thoracic…
View article: Impact of Salvage Surgery following Colonic Endoscopic Polypectomy for Patients with Invasive Neoplasia
Impact of Salvage Surgery following Colonic Endoscopic Polypectomy for Patients with Invasive Neoplasia Open
Background: Invasive neoplasia (Tis-T1) are increasingly being encountered in the daily routine of endoscopic polypectomy. However, the need for salvage surgery following endoscopic therapy for invasive neoplasia is controversially discuss…
View article: Prolonged Exposure to Oxaliplatin during HIPEC Improves Effectiveness in a Preclinical Micrometastasis Model
Prolonged Exposure to Oxaliplatin during HIPEC Improves Effectiveness in a Preclinical Micrometastasis Model Open
Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) was considered a promising treatment for patients with peritoneal metastasis from colorectal cancer. However, the recently published randomized controlle…
View article: Endoscopic Management for Post-Surgical Complications after Resection of Esophageal Cancer
Endoscopic Management for Post-Surgical Complications after Resection of Esophageal Cancer Open
Background: Esophageal cancer (EC) is the sixth-leading cause of cancer-related deaths in the world. Esophagectomy is the most effective treatment for patients without invasion of adjacent organs or distant metastasis. Complications and re…
View article: Restored TDCA and valine levels imitate the effects of bariatric surgery
Restored TDCA and valine levels imitate the effects of bariatric surgery Open
Background: Obesity is widespread and linked to various co-morbidities. Bariatric surgery has been identified as the only effective treatment, promoting sustained weight loss and the remission of co-morbidities. Methods: Metabolic profilin…
View article: Regulatory Immune Cells in Idiopathic Pulmonary Fibrosis: Friends or Foes?
Regulatory Immune Cells in Idiopathic Pulmonary Fibrosis: Friends or Foes? Open
The immune system is receiving increasing attention for interstitial lung diseases, as knowledge on its role in fibrosis development and response to therapies is expanding. Uncontrolled immune responses and unbalanced injury-inflammation-r…
View article: Targeting age‐specific changes in CD4<sup>+</sup> T cell metabolism ameliorates alloimmune responses and prolongs graft survival
Targeting age‐specific changes in CD4<sup>+</sup> T cell metabolism ameliorates alloimmune responses and prolongs graft survival Open
Age impacts alloimmunity. Effects of aging on T‐cell metabolism and the potential to interfere with immunosuppressants have not been explored yet. Here, we dissected metabolic pathways of CD4 + and CD8 + T cells in aging and offer novel im…
View article: Restored TDCA and Valine Levels Imitate the Effects of Bariatric Surgery
Restored TDCA and Valine Levels Imitate the Effects of Bariatric Surgery Open
Obesity is widespread and linked to various co-morbidities. Bariatric surgery has been identified as the only effective treatment, promoting sustained weight loss and the remission of co-morbidities. We performed sleeve-gastrectomies (SGx)…
View article: COVID-19-related absence among surgeons: development of an international surgical workforce prediction model
COVID-19-related absence among surgeons: development of an international surgical workforce prediction model Open
Background During the initial COVID-19 outbreak up to 28.4 million elective operations were cancelled worldwide, in part owing to concerns that it would be unsustainable to maintain elective surgery capacity because of COVID-19-related sur…
View article: Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation Open
Older organs represent an untapped potential to close the gap between demand and supply in organ transplantation but are associated with age-specific responses to injury and increased immunogenicity, thereby aggravating transplant outcomes…
View article: Expanding pancreas donor pool by evaluation of unallocated organs after brain death
Expanding pancreas donor pool by evaluation of unallocated organs after brain death Open
Background: Pancreas graft quality directly affects morbidity and mortality rates after pancreas transplantation (PTx). The criteria for pancreas graft allocation are restricted, which has decreased the number of available organs. Suitable…
View article: Recall features and allorecognition in innate immunity
Recall features and allorecognition in innate immunity Open
Alloimmunity traditionally distinguishes short-lived, rapid and nonspecific innate immune responses from adaptive immune responses that are characterized by a highly specific response initiated in a delayed fashion. Key players of innate i…
View article: Rapamycin Prolongs Graft Survival and Induces CD4+IFN-γ+IL-10+ Regulatory Type 1 Cells in Old Recipient Mice
Rapamycin Prolongs Graft Survival and Induces CD4+IFN-γ+IL-10+ Regulatory Type 1 Cells in Old Recipient Mice Open
Our results highlight novel aspects of age-dependent immunosuppressive effects of rapamycin, with relevance for age-specific immunosuppressive regimens.
View article: MP06-07 CD4 <sup>+</sup> IFN-γ <sup>+</sup> IL-10 <sup>+</sup> CELLS FACILITATE A PROLONGATION OF GRAFT SURVIVAL IN OLD RECIPIENT MICE TREATED WITH RAPAMYCIN
MP06-07 CD4 <sup>+</sup> IFN-γ <sup>+</sup> IL-10 <sup>+</sup> CELLS FACILITATE A PROLONGATION OF GRAFT SURVIVAL IN OLD RECIPIENT MICE TREATED WITH RAPAMYCIN Open
You have accessJournal of UrologyTransplantation & Vascular Surgery: Renal Transplantation & Vascular Surgery I1 Apr 2017MP06-07 CD4+IFN-γ+IL-10+ CELLS FACILITATE A PROLONGATION OF GRAFT SURVIVAL IN OLD RECIPIENT MICE TREATED WITH RAPAMYCI…