Markus Räschle
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View article: A protein-specific priority code in presequences determines the efficiency of mitochondrial protein import
A protein-specific priority code in presequences determines the efficiency of mitochondrial protein import Open
The biogenesis of mitochondria relies on the import of hundreds of different precursor proteins from the cytosol. Most of these proteins are synthesized with N-terminal presequences which serve as mitochondrial targeting signals. Presequen…
View article: Aneuploidy-induced proteostasis disruption impairs mitochondrial functions and mediates aggregation of mitochondrial precursor proteins through SQSTM1/p62
Aneuploidy-induced proteostasis disruption impairs mitochondrial functions and mediates aggregation of mitochondrial precursor proteins through SQSTM1/p62 Open
Aneuploidy, or aberrant chromosomal content, disrupts cellular proteostasis through altered expression of numerous proteins. Aneuploid cells accumulate SQSTM1/p62-positive cytosolic bodies, exhibit impaired protein folding, and show altere…
View article: Explainable Machine Learning Identifies Factors for Dosage Compensation in Aneuploid Human Cancer Cells
Explainable Machine Learning Identifies Factors for Dosage Compensation in Aneuploid Human Cancer Cells Open
Aneuploidy, a hallmark of cancer, leads to widespread changes in chromosome copy number, altering the abundance of hundreds or thousands of proteins. How-ever, evidence suggests that levels of proteins encoded on affected chromosomes are o…
View article: BTRR complex deficiency is a driver for genomic instability in Bloom syndrome
BTRR complex deficiency is a driver for genomic instability in Bloom syndrome Open
Biallelic loss-of-function (LoF) variants in the BTRR complex members BLM , TOP3A, RMI1, and RMI2 cause Bloom syndrome (BS). The BTRR complex mainly acts on DNA replication and DNA repair processes, and dysfunction of this complex underlie…
View article: Pex30-dependent membrane contact sites maintain ER lipid homeostasis
Pex30-dependent membrane contact sites maintain ER lipid homeostasis Open
In eukaryotic cells, communication between organelles and the coordination of their activities depend on membrane contact sites (MCS). How MCS are regulated under the dynamic cellular environment remains poorly understood. Here, we investi…
View article: Proteogenomic analysis reveals adaptive strategies for alleviating the consequences of aneuploidy in cancer
Proteogenomic analysis reveals adaptive strategies for alleviating the consequences of aneuploidy in cancer Open
Aneuploidy is prevalent in cancer and associates with fitness advantage and poor patient prognosis. Yet, experimentally induced aneuploidy initially leads to adverse effects and impaired proliferation, suggesting that cancer cells must ada…
View article: TTF2 promotes replisome eviction from stalled forks in mitosis
TTF2 promotes replisome eviction from stalled forks in mitosis Open
When cells enter mitosis with under-replicated DNA, sister chromosome segregation is compromised, which can lead to massive genome instability. The replisome-associated E3 ubiquitin ligase TRAIP mitigates this threat by ubiquitylating the …
View article: Aneuploidy-induced proteostasis disruption impairs mitochondrial functions and mediates aggregation of mitochondrial precursor proteins through SQSTM1/p62
Aneuploidy-induced proteostasis disruption impairs mitochondrial functions and mediates aggregation of mitochondrial precursor proteins through SQSTM1/p62 Open
Aberrant chromosomal content, or aneuploidy, profoundly affects cellular physiology. Even a gain of a single chromosome disrupts proteostasis due to overexpression of numerous proteins. Consequently, cells accumulate SQSTM1/p62-positive cy…
View article: A priority code in presequences: mitochondrial targeting signals assign specific import characteristics to precursor proteins
A priority code in presequences: mitochondrial targeting signals assign specific import characteristics to precursor proteins Open
The biogenesis of mitochondria relies on the import of hundreds of different precursor proteins from the cytosol. Most of these proteins are synthesized with N-terminal presequences which serve as mitochondrial targeting signals. Presequen…
View article: The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria
The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria Open
Most mitochondrial proteins are synthesized on cytosolic ribosomes and imported into mitochondria in a post-translational reaction. Mitochondrial precursor proteins which use the ER-SURF pathway employ the surface of the endoplasmic reticu…
View article: Distinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress
Distinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress Open
Mitochondria consist of hundreds of proteins, most of which are inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions remains poorly understood. …
View article: Proteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer
Proteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer Open
Aneuploidy is prevalent in cancer and associates with fitness advantage and poor patient prognosis. Yet, experimentally induced aneuploidy initially leads to adverse effects and impaired proliferation, suggesting that cancer cells must ada…
View article: TopBP1 utilises a bipartite GINS binding mode to support genome replication
TopBP1 utilises a bipartite GINS binding mode to support genome replication Open
Activation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for replication origin firing, and as such for faithful genetic inheritance. Our biochemical and structural studies demonstrate that the helicase activator …
View article: The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis
The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) expresses high amounts of the protein Orf9b to target the mitochondrial outer membrane protein Tom70. Tom70 serves as an import receptor for mitochondrial precursors and, ind…
View article: The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria
The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria Open
Most mitochondrial proteins are synthesized on cytosolic ribosomes and imported into mitochondria in a post-translational reaction. Mitochondrial precursor proteins which use the ER-SURF pathway employ the surface of the endoplasmic reticu…
View article: Supplementary Table S1 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion
Supplementary Table S1 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion Open
The supplementary Table S1 provides the results of the mass spectrometry results comparing protein content of microvesicles from melanoma cells with or without PLK4 overexpression.
View article: Figure S3 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion
Figure S3 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion Open
Figure S3 shows that conditioned media from invasive melanoma cells or from non.-invasive cells overexpressing PLK4 or STIL do not induce supernumerary centrosomes.
View article: Figure S1 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion
Figure S1 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion Open
Figure S1 shows that low-dose Taxol or CKAP5 siRNA treatment does not induce cell cycle alterations or cell death while CKAP overexpression increases microtubule growth rates.
View article: Figure S4 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion
Figure S4 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion Open
Figure S4 shows that microvesicles from non-invasive melanoma cells with PLK4 overexpression increase microtubule growth rates in recipient cells.
View article: Figure S1 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion
Figure S1 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion Open
Figure S1 shows that low-dose Taxol or CKAP5 siRNA treatment does not induce cell cycle alterations or cell death while CKAP overexpression increases microtubule growth rates.
View article: Data from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion
Data from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion Open
The acquisition of cell invasiveness is the key transition from benign melanocyte hyperplasia to aggressive melanoma. Recent work has provided an intriguing new link between the presence of supernumerary centrosomes and increased cell inva…
View article: Supplementary Video S1 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion
Supplementary Video S1 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion Open
The supplementary Movie S1 shows an example movie displaying the detection of EB3-GFP in a living interphase melanoma cell,
View article: Supplementary Table S1 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion
Supplementary Table S1 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion Open
The supplementary Table S1 provides the results of the mass spectrometry results comparing protein content of microvesicles from melanoma cells with or without PLK4 overexpression.
View article: Figure S4 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion
Figure S4 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion Open
Figure S4 shows that microvesicles from non-invasive melanoma cells with PLK4 overexpression increase microtubule growth rates in recipient cells.
View article: Supplementary Video S1 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion
Supplementary Video S1 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion Open
The supplementary Movie S1 shows an example movie displaying the detection of EB3-GFP in a living interphase melanoma cell,
View article: Data from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion
Data from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion Open
The acquisition of cell invasiveness is the key transition from benign melanocyte hyperplasia to aggressive melanoma. Recent work has provided an intriguing new link between the presence of supernumerary centrosomes and increased cell inva…
View article: Figure S2 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion
Figure S2 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion Open
Figure S2 shows that CKAP5, STIL or PLK4 overexpression is not sufficient to significantly increase spheroid outgrowth in 3D matrices.
View article: Figure S2 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion
Figure S2 from Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion Open
Figure S2 shows that CKAP5, STIL or PLK4 overexpression is not sufficient to significantly increase spheroid outgrowth in 3D matrices.