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View article: Hydration and health at ages 40–70 years in Salzburg Austria is associated with a median total water intake over 40 mL/kg including at least 1 L/d plain drinking water
Hydration and health at ages 40–70 years in Salzburg Austria is associated with a median total water intake over 40 mL/kg including at least 1 L/d plain drinking water Open
Introduction To address longstanding questions about how much plain water to drink for hydration and long-term health, this study described the plain water intake (PWI) of people without chronic health conditions (CHC), at ages 40–70 years…
View article: Feasibility and Reliability of the Osteoarthritis Quality Indicator Questionnaire for Assessing Osteoarthritis Care in Bilingual General Practices in South Tyrol/Alto Adige, Italy
Feasibility and Reliability of the Osteoarthritis Quality Indicator Questionnaire for Assessing Osteoarthritis Care in Bilingual General Practices in South Tyrol/Alto Adige, Italy Open
Background and Objectives: Evaluating osteoarthritis (OA) care quality is increasingly relevant for service improvement and benchmarking purposes. The Osteoarthritis Quality Indicator questionnaire (OA-QI) measures patient-reported guideli…
View article: Feasibility and Reliability of the OA-QI v3 for Assessing Osteoarthritis Care in Bilingual General Practices in South Tyrol/Alto Adige, Italy
Feasibility and Reliability of the OA-QI v3 for Assessing Osteoarthritis Care in Bilingual General Practices in South Tyrol/Alto Adige, Italy Open
Background/Objectives: Evaluating osteoarthritis (OA) care quality is increasingly relevant for service improvement and benchmarking purposes. The Osteoarthritis Quality Indicator questionnaire (OA-QI) measures patient-reported guideline-c…
View article: Spatial Transcriptomics Characterisation of Radionecrotic Changes in Glioblastoma Patients
Spatial Transcriptomics Characterisation of Radionecrotic Changes in Glioblastoma Patients Open
Background: IDH-wildtype Glioblastoma (GB) is the most prevalent primary CNS tumour in adults. The standard treatment involves radiotherapy, which can cause radionecrotic changes. Progressive GB and radionecrotic changes can be challenging…
View article: KS03.6.A THE RECURRENT TISSUE STATES ACROSS ADULT GLIOMAS AS REVEALED BY SPATIAL TRANSCRIPTOMICS
KS03.6.A THE RECURRENT TISSUE STATES ACROSS ADULT GLIOMAS AS REVEALED BY SPATIAL TRANSCRIPTOMICS Open
BACKGROUND Adult gliomas are a diverse class of tumors with substantial molecular and pathological variation. While prior single-cell omics studies have characterized intratumoral heterogeneity, they often examined tumors in isolation, thu…
View article: A REGISTER-BASED, EPIDEMIOLOGICAL EVALUATION OF DISEASE ACTIVITY AND FUNCTIONAL PERFORMANCE IN ANKYLOSING SPONDYLITIS PATIENTS AFTER MULTIMODAL SPA THERAPY IN AUSTRIA
A REGISTER-BASED, EPIDEMIOLOGICAL EVALUATION OF DISEASE ACTIVITY AND FUNCTIONAL PERFORMANCE IN ANKYLOSING SPONDYLITIS PATIENTS AFTER MULTIMODAL SPA THERAPY IN AUSTRIA Open
Objective Evidence regarding the impact of multimodal treatment on disease activity and functional performance in ankylosing spondylitis (AS) remains scarce. This study aims to evaluate changes in these outcomes after multimodal rehabilita…
View article: Cannabidiol Is a Potential Inhibitor of Ferroptosis in Human Articular Chondrocytes
Cannabidiol Is a Potential Inhibitor of Ferroptosis in Human Articular Chondrocytes Open
The present study investigates the effects of cannabidiol (CBD), the major non‐psychoactive compound of Cannabis sativa L. extracts, on ferroptotic cell death in human articular chondrocytes. Exposure to known ferroptosis inducers RSL3, er…
View article: Obituary Peter H. Deetjen (1932–2024): Editor-in-Chief of Pflügers Archiv from 1970 to 1998
Obituary Peter H. Deetjen (1932–2024): Editor-in-Chief of Pflügers Archiv from 1970 to 1998 Open
View article: Exploring risk factors for comorbid depression in osteoarthritis: a scoping review protocol
Exploring risk factors for comorbid depression in osteoarthritis: a scoping review protocol Open
Introduction Globally, osteoarthritis (OA) is the most prevalent musculoskeletal disease, affecting approximately 600 million people. It is characterised by progressive degeneration of the articular cartilage, osteophyte formation and asym…
View article: The Cdk inhibitor dinaciclib as a promising anti-tumorigenic agent in biliary tract cancer
The Cdk inhibitor dinaciclib as a promising anti-tumorigenic agent in biliary tract cancer Open
Biliary tract cancer (BTC) is a rare malignancy with rising incidence. The therapeutic options are limited and the overall survival remains poor. Cyclin-dependent kinases, drivers of cell cycle and transcription have numerous biological fu…
View article: Delayed vacuolation in mammalian cells caused by hypotonicity and ion loss
Delayed vacuolation in mammalian cells caused by hypotonicity and ion loss Open
Prolonged exposure of mammalian cells to hypotonic environments stimulates the development of sometimes large and numerous vacuoles of unknown origin. Here, we investigate the nature and formation of these vacuoles, which we term LateVacs.…
View article: Exploring Risk Factors for Comorbid Depression in Osteoarthritis: A Scoping Review Protocol
Exploring Risk Factors for Comorbid Depression in Osteoarthritis: A Scoping Review Protocol Open
Introduction Globally, osteoarthritis (OA) is the most prevalent musculoskeletal disease, affecting approximately 600 million people. It is characterised by progressive degeneration of the articular cartilage, osteophyte formation, and asy…
View article: The efficacy of ferroptosis-inducing compounds IKE and RSL3 correlates with the expression of ferroptotic pathway regulators CD71 and SLC7A11 in biliary tract cancer cells
The efficacy of ferroptosis-inducing compounds IKE and RSL3 correlates with the expression of ferroptotic pathway regulators CD71 and SLC7A11 in biliary tract cancer cells Open
Introduction Biliary tract cancer (BTC) is a lethal disease with a bad overall survivability, partly arising from inadequate therapeutic alternatives, detection at a belated stage, and a resistance to common therapeutic approaches. Ferropt…
View article: Paracelsus 10000 data from Austria suggest >1 L/D drinking water for hydration and health into middle-age
Paracelsus 10000 data from Austria suggest >1 L/D drinking water for hydration and health into middle-age Open
View article: P18.04.B SINGLE CELL TRANSCRIPTOMIC ANALYSIS IDENTIFIES DISTINCT INTRATUMORAL SUBCLONES IN MENINGIOMA
P18.04.B SINGLE CELL TRANSCRIPTOMIC ANALYSIS IDENTIFIES DISTINCT INTRATUMORAL SUBCLONES IN MENINGIOMA Open
BACKGROUND Meningiomas arise from the leptomeninges of the brain and spinal cord. Despite being the most common intracranial tumor in adults, risk stratification remains challenging. Currently, tumors are graded based on histology as well …
View article: Ouabain at nanomolar concentrations is cytotoxic for biliary tract cancer cells
Ouabain at nanomolar concentrations is cytotoxic for biliary tract cancer cells Open
Biliary tract cancer is a deadly disease with limited therapeutic options. Ouabain is a well-known inhibitor of the pumping function of Na + /K + -ATPase, though there is evidence that low concentrations of ouabain lead to a reduction of c…
View article: Improvement of Pain Symptoms in Musculoskeletal Diseases After Multimodal Spa Therapy in the Austrian Gastein Valley—A Study Based on Longitudinal Registry Data
Improvement of Pain Symptoms in Musculoskeletal Diseases After Multimodal Spa Therapy in the Austrian Gastein Valley—A Study Based on Longitudinal Registry Data Open
Objective: The study aim was to investigate the course of pain in rest and motion in seven different rheumatic diseases (RMD), prior and after multimodal spa therapy including low-dose radon treatment and at 3-, 6-; and 9-month follow up. …
View article: Change in Metabolomic Profile Associated with an Average Increase in Plain Water Intake of >+1 L/Day, Sustained Over 4 Weeks, in Healthy Young Men with Initial Total Water Intake Below 2 L/Day
Change in Metabolomic Profile Associated with an Average Increase in Plain Water Intake of >+1 L/Day, Sustained Over 4 Weeks, in Healthy Young Men with Initial Total Water Intake Below 2 L/Day Open
Background/Aims: Cells adapt to chronic extracellular hypotonicity by altering metabolism. Corresponding effects of sustained hypotonic exposure at the whole-person level remain to be confirmed and characterized in clinical and population-…
View article: Patient-Reported Quality of Care for Osteoarthritis in General Practice in South Tyrol, Italy: Protocol for Translation, Validation and Assessment of the OsteoArthritis Quality Indicator Questionnaire (OA-QI)
Patient-Reported Quality of Care for Osteoarthritis in General Practice in South Tyrol, Italy: Protocol for Translation, Validation and Assessment of the OsteoArthritis Quality Indicator Questionnaire (OA-QI) Open
Background: Evidence-based recommendations for the treatment of knee and hip osteoarthritis are similar internationally. Nevertheless, clinical practice varies across countries. Instruments for measuring quality have been developed to impr…
View article: Evaluation of Tazemetostat as a Therapeutically Relevant Substance in Biliary Tract Cancer
Evaluation of Tazemetostat as a Therapeutically Relevant Substance in Biliary Tract Cancer Open
Biliary tract cancer (BTC) is a gastrointestinal malignancy associated with a poor survival rate. Current therapies encompass palliative and chemotherapeutic treatment as well as radiation therapy, which results in a median survival of onl…
View article: Subcutaneous rituximab in patients with diffuse large B cell lymphoma and follicular lymphoma: Final results of the non‐interventional study <scp>MabSCale</scp>
Subcutaneous rituximab in patients with diffuse large B cell lymphoma and follicular lymphoma: Final results of the non‐interventional study <span>MabSCale</span> Open
Background Rituximab has become a standard treatment for non‐Hodgkin lymphoma. Clinical studies have demonstrated the efficacy of rituximab in combination with standard chemotherapies in the treatment of follicular lymphoma (FL) and diffus…
View article: Sustained improvements in EQ-5D utility scores and self-rated health status in patients with ankylosing spondylitis after spa treatment including low-dose radon – an analysis of prospective radon indication registry data
Sustained improvements in EQ-5D utility scores and self-rated health status in patients with ankylosing spondylitis after spa treatment including low-dose radon – an analysis of prospective radon indication registry data Open
View article: Ferroptosis in Hepatocellular Carcinoma: Mechanisms, Drug Targets and Approaches to Clinical Translation
Ferroptosis in Hepatocellular Carcinoma: Mechanisms, Drug Targets and Approaches to Clinical Translation Open
Ferroptosis, an iron and reactive oxygen species (ROS)-dependent non-apoptotic type of regulated cell death, is characterized by a massive iron overload and peroxidation of polyunsaturated fatty acids (PUFAs), which finally results in cell…
View article: Sprifermin for Treatment of Osteoarthritis: Recombinant Fibroblast Growth Factor 18 as a Possible Disease-Modifying Knee Osteoarthritis Drug
Sprifermin for Treatment of Osteoarthritis: Recombinant Fibroblast Growth Factor 18 as a Possible Disease-Modifying Knee Osteoarthritis Drug Open
Osteoarthritis (OA) is a major cause of pain and disability in adults, affecting approximately 150 million people worldwide. It is most prevalent in knees and hips. Major risk factors are age, female sex, prior joint injury, and obesity. O…
View article: Projected number of osteoarthritis patients in Austria for the next decades – quantifying the necessity of treatment and prevention strategies in Europe
Projected number of osteoarthritis patients in Austria for the next decades – quantifying the necessity of treatment and prevention strategies in Europe Open
View article: Sustained Improvements in EQ-5D Utility Scores and Self-rated Health Status in Patients With Ankylosing Spondylitis After Spa Treatment Including Low-dose Radon
Sustained Improvements in EQ-5D Utility Scores and Self-rated Health Status in Patients With Ankylosing Spondylitis After Spa Treatment Including Low-dose Radon Open
Background Patients with ankylosing spondylitis (AS) have significantly lower quality of life (QoL) than the general population. Holistic interventions addressing QoL include spa- or balneotherapy. Inclusion of radon in spa-therapy treatme…
View article: Low pH Attenuates Apoptosis by Suppressing the Volume-Sensitive Outwardly Rectifying (VSOR) Chloride Current in Chondrocytes
Low pH Attenuates Apoptosis by Suppressing the Volume-Sensitive Outwardly Rectifying (VSOR) Chloride Current in Chondrocytes Open
In a variety of physiological and pathophysiological conditions, cells are exposed to acidic environments. Severe synovial fluid acidification also occurs in a progressive state of osteoarthritis (OA) affecting articular chondrocytes. In p…
View article: Projected number of osteoarthritis patients in Austria for the next decades – quantifying the necessity of treatment and prevention strategies in Europe
Projected number of osteoarthritis patients in Austria for the next decades – quantifying the necessity of treatment and prevention strategies in Europe Open
Background The present study aimed to predict the expected number of patients with osteoarthritis (OA) in Austria up to the year 2080. Methods Demographic data and population projections between 2019 and 2080 were obtained from European au…
View article: Editorial: Ion and Water Transport in Cell Death
Editorial: Ion and Water Transport in Cell Death Open
EDITORIAL article Front. Cell Dev. Biol., 09 September 2021 | https://doi.org/10.3389/fcell.2021.757033
View article: HDAC Screening Identifies the HDAC Class I Inhibitor Romidepsin as a Promising Epigenetic Drug for Biliary Tract Cancer
HDAC Screening Identifies the HDAC Class I Inhibitor Romidepsin as a Promising Epigenetic Drug for Biliary Tract Cancer Open
Inhibition of histone deacetylases (HDACs) is a promising anti-cancer approach. For biliary tract cancer (BTC), only limited therapeutic options are currently available. Therefore, we performed a comprehensive investigation of HDAC express…