Markus Schwalbe
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View article: Serotonin modulation of metabolism and stress response in Pseudomonas fluorescens
Serotonin modulation of metabolism and stress response in Pseudomonas fluorescens Open
The findings reveal a novel mechanism by which serotonin modulates the metabolism and stress responses of P. fluorescens. This study provides insight into how P. fluorescens adapts to serotonin-rich environments, such as in celiac disease,…
View article: Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism
Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism Open
Mangiferin (MAN), a natural C-glycosylxanthone, is recognized for its health-promoting effects in traditional medicinal preparations. However, its poor bioavailability and limited intestinal permeability restrict its direct biological acti…
View article: Prebiotic utilisation provides <i>Lactiplantibacillus plantarum</i> a competitive advantage <i>in vitro</i> , but is not reflected by an increased intestinal fitness
Prebiotic utilisation provides <i>Lactiplantibacillus plantarum</i> a competitive advantage <i>in vitro</i> , but is not reflected by an increased intestinal fitness Open
Synbiotics combine the concepts of probiotics and prebiotics to synergistically enhance the health-associated effects of both components. Previously, we have shown that the intestinal persistence of inulin-utilizing L. plantarum Lp900 is s…
View article: Dynamic effects of probiotic formula ecologic®825 on human small intestinal ileostoma microbiota: a network theory approach
Dynamic effects of probiotic formula ecologic®825 on human small intestinal ileostoma microbiota: a network theory approach Open
The gut microbiota plays a pivotal role in health and disease. The use of probiotics as microbiota-targeted therapies is a promising strategy to improve host health. However, the molecular mechanisms involved in such therapies are often no…
View article: Probiotics supplementation to adult human small intestinal stoma microbiota causes dynamic increase in the community resistance to perturbations and nutrient utilization
Probiotics supplementation to adult human small intestinal stoma microbiota causes dynamic increase in the community resistance to perturbations and nutrient utilization Open
The gut microbiota plays a pivotal role in health and disease. The use of probiotics as microbiota-targeted therapies is a promising strategy to improve host health. However, dynamic molecular mechanisms are often not elucidated, especiall…
View article: Potential binding modes of the gut bacterial metabolite, 5-hydroxyindole, to the intestinal L-type calcium channels and its impact on the microbiota in rats
Potential binding modes of the gut bacterial metabolite, 5-hydroxyindole, to the intestinal L-type calcium channels and its impact on the microbiota in rats Open
Intestinal microbiota and microbiota-derived metabolites play a key role in regulating the host physiology. Recently, we have identified a gut-bacterial metabolite, namely 5-hydroxyindole, as a potent stimulant of intestinal motility via i…
View article: Implications of Parkinson’s disease-associated alterations in the oral and gut microbiome on vitamin B12 biosynthesis and levodopa bioavailability
Implications of Parkinson’s disease-associated alterations in the oral and gut microbiome on vitamin B12 biosynthesis and levodopa bioavailability Open
Small intestinal bacteria harboring tyrosine decarboxylase (TDC) activity was shown to reduce levels of the main treatment for Parkinson’s disease (PD), levodopa. However, it remains obscure whether the relative abundance of bacterial-TDC …
View article: Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterparts
Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterparts Open
The gut microbiota is in continuous interaction with the intestinal mucosa via metabolic, neuro-immunological, and neuroendocrine pathways. Disruption in levels of antimicrobial peptides produced by the enteroendocrine cells, such as cates…
View article: Catestatin selects for colonization of antimicrobial-resistant gut bacterial communities
Catestatin selects for colonization of antimicrobial-resistant gut bacterial communities Open
The gut microbiota is in continuous interaction with the innermost layer of the gut, namely the epithelium. One of the various functions of the gut epithelium, is to keep the microbes at bay to avoid overstimulation of the underlying mucos…
View article: Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterparts
Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterparts Open
The gut microbiota is in continuous interaction with the intestinal mucosa via metabolic, neuro- immunological, and neuroendocrine pathways. Disruption in levels of antimicrobial peptides produced by the enteroendocrine cells, such as cate…
View article: Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterparts
Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterparts Open
Background The gut microbiota is in continuous interaction with the intestinal mucosa via metabolic, neuro-immunological, and neuroendocrine pathways. Disruption in levels of antimicrobial peptides produced by the enteroendocrine cells, su…
View article: Oral Administration of the Gut-bacterial Metabolite 5-hydroxyindole and Its Subsequent Acceleration of Gut Motility Have Marginal Effects on the Rat Microbiota
Oral Administration of the Gut-bacterial Metabolite 5-hydroxyindole and Its Subsequent Acceleration of Gut Motility Have Marginal Effects on the Rat Microbiota Open
Background: Intestinal microbiota and microbiota-derived metabolites play a key role in regulating the host physiology, including gut motility. We have previously shown that a wide variety of gut bacteria can produce 5-hydroxyindole from i…
View article: Catestatin Selects for the Colonization of Antimicrobial-Resistant Gut Bacterial Communities
Catestatin Selects for the Colonization of Antimicrobial-Resistant Gut Bacterial Communities Open
The gut microbiota is in continuous interaction with the innermost layer of the gut, namely the epithelium. Among the various functions of the gut epithelium, is to keep the microbes at bay to avoid overstimulation of the underlying mucosa…
View article: Catestatin selects for the colonization of antimicrobial-resistant gut bacterial communities
Catestatin selects for the colonization of antimicrobial-resistant gut bacterial communities Open
The gut microbiota is in continuous interaction with the innermost layer of the gut, namely the epithelium. One of the various functions of the gut epithelium, is to keep the microbes at bay to avoid overstimulation of the underlying mucos…
View article: Stability of Methylphenidate under Various pH Conditions in the Presence or Absence of Gut Microbiota
Stability of Methylphenidate under Various pH Conditions in the Presence or Absence of Gut Microbiota Open
Methylphenidate is one of the most widely used oral treatments for attention-deficit/hyperactivity disorder (ADHD). The drug is mainly absorbed in the small intestine and has low bioavailability. Accordingly, a high interindividual variabi…
View article: Dietary Inulin Increases <i>Lactiplantibacillus plantarum</i> Strain Lp900 Persistence in Rats Depending on the Dietary-Calcium Level
Dietary Inulin Increases <i>Lactiplantibacillus plantarum</i> Strain Lp900 Persistence in Rats Depending on the Dietary-Calcium Level Open
Synbiotics combine probiotics with prebiotics to synergistically elicit a health benefit in the consumer. Previous studies have shown that prebiotics can selectively stimulate the growth in the intestine of specific bacterial strains.
View article: Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels
Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels Open
Microbial conversion of dietary or drug substrates into small bioactive molecules represents a regulatory mechanism by which the gut microbiota alters intestinal physiology. Here, we show that a wide variety of gut bacteria can metabolize …
View article: <i>Kmasker plants</i> – a tool for assessing complex sequence space in plant species
<i>Kmasker plants</i> – a tool for assessing complex sequence space in plant species Open
Summary Many plant genomes display high levels of repetitive sequences. The assembly of these complex genomes using short high‐throughput sequence reads is still a challenging task. Underestimation or disregard of repeat complexity in thes…