Christoph Sommer
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View article: Light-microscopy-based connectomic reconstruction of mammalian brain tissue
Light-microscopy-based connectomic reconstruction of mammalian brain tissue Open
The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connec…
View article: Super-resolution expansion microscopy in plant roots
Super-resolution expansion microscopy in plant roots Open
Super-resolution methods provide far better spatial resolution than the optical diffraction limit of about half the wavelength of light (∼200–300 nm). Nevertheless, they have yet to attain widespread use in plants, largely due to plants' c…
View article: Spinal neuron diversity scales exponentially with swim-to-limb transformation during frog metamorphosis
Spinal neuron diversity scales exponentially with swim-to-limb transformation during frog metamorphosis Open
SUMMARY Vertebrates exhibit a wide range of motor behaviors, ranging from swimming to complex limb-based movements. Here we take advantage of frog metamorphosis, which captures a swim-to-limb-based movement transformation during the develo…
View article: Mating-induced release of oxytocin in the mouse lateral septum: Implications for social fear extinction
Mating-induced release of oxytocin in the mouse lateral septum: Implications for social fear extinction Open
In mammals, some physiological conditions are associated with the high brain oxytocin (OXT) system activity. These include lactation in females and mating in males and females, both of which have been linked to reduced stress responsivenes…
View article: Analysis of Eligibility of the S1 Corridor for the Trans-Sacral Screw Placement in Geriatric Patients
Analysis of Eligibility of the S1 Corridor for the Trans-Sacral Screw Placement in Geriatric Patients Open
Background Minimal-invasive placement of a trans-sacral screw represents an increasingly popular method of fixation for Fragility Fractures of the Pelvis (FFP), with variable upper sacral anatomy representing the main challenge. Little is …
View article: Light-microscopy based dense connectomic reconstruction of mammalian brain tissue
Light-microscopy based dense connectomic reconstruction of mammalian brain tissue Open
The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connec…
View article: Super-resolution expansion microscopy in plant roots
Super-resolution expansion microscopy in plant roots Open
Super-resolution methods enable spatial resolution far better than the optical diffraction limit of about half the wavelength of light (∼200-300 nm) but have yet to attain widespread use in plants, owing in large part to plants’ challengin…
View article: Reduction Technique of Atypical Irreducible Posterolateral Quadrant Dislocation in Proximal Tibial Fracture with Entrapment of the Popliteal Tendon
Reduction Technique of Atypical Irreducible Posterolateral Quadrant Dislocation in Proximal Tibial Fracture with Entrapment of the Popliteal Tendon Open
Summary Treatment of proximal tibia fractures with involvement of the posterolateral quadrant remains challenging due to the difficulty in achieving adequate reduction and fixation. We describe a rare but special fracture pattern with an i…
View article: Imaging brain tissue architecture across millimeter to nanometer scales
Imaging brain tissue architecture across millimeter to nanometer scales Open
Mapping the complex and dense arrangement of cells and their connectivity in brain tissue demands nanoscale spatial resolution imaging. Super-resolution optical microscopy excels at visualizing specific molecules and individual cells but f…
View article: Minimally invasive plate osteosynthesis (MIPO) for scapular fractures
Minimally invasive plate osteosynthesis (MIPO) for scapular fractures Open
Objective Presentation of a minimally invasive surgical approach for the treatment of scapular fractures and the clinical outcome using this technique. Indications Displaced extra-articular fractures of the scapula body and glenoid neck (A…
View article: Suitable electrospinning approaches for recombinant spider silk proteins
Suitable electrospinning approaches for recombinant spider silk proteins Open
Among the versatile opportunities of processing recombinant spider silk proteins into coatings, hydrogels, particles, fibrils and foams, electrospinning provides a further highly important morphology: submicron- and nanofibers. These fiber…
View article: Dense 4D nanoscale reconstruction of living brain tissue
Dense 4D nanoscale reconstruction of living brain tissue Open
Three-dimensional (3D) reconstruction of living brain tissue down to an individual synapse level would create opportunities for decoding the dynamics and structure–function relationships of the brain’s complex and dense information process…
View article: Clavicular Hook Plate versus Dog-Bone Technique for Acute High-Grade Acromioclavicular Joint Dislocation – A Retrospective Cohort Study Comparing Clinical Outcome Scores, Complications and Costs
Clavicular Hook Plate versus Dog-Bone Technique for Acute High-Grade Acromioclavicular Joint Dislocation – A Retrospective Cohort Study Comparing Clinical Outcome Scores, Complications and Costs Open
Background Arthroscopically assisted coracoclavicular (CC) ligament fixation techniques have been promoted as providing superior outcomes for the treatment of acute high-grade acromioclavicular joint (ACJ) dislocations. Nevertheless, there…
View article: A hydraulic feedback loop between mesendoderm cell migration and interstitial fluid relocalization promotes embryonic axis formation in zebrafish
A hydraulic feedback loop between mesendoderm cell migration and interstitial fluid relocalization promotes embryonic axis formation in zebrafish Open
Interstitial fluid (IF) accumulation between embryonic cells is thought to be important for embryo patterning and morphogenesis. Here, we identify a positive mechanical feedback loop between cell migration and IF relocalization and find th…
View article: Author Correction: In vitro reconstitution of Escherichia coli divisome activation
Author Correction: In vitro reconstitution of Escherichia coli divisome activation Open
1.The original caption of Fig. 3b incorrectly read "b.The mobility of both proteins decreases with increasing concentrations, but R286W remains 10x more mobile and has a 2-10x lower lifetime".The correct version replaces this sentence with…
View article: Three-dimensional visualization of planta clathrin-coated vesicles at ultrastructural resolution
Three-dimensional visualization of planta clathrin-coated vesicles at ultrastructural resolution Open
Biological systems are the sum of their dynamic three-dimensional (3D) parts. Therefore, it is critical to study biological structures in 3D and at high resolution to gain insights into their physiological functions. Electron microscopy of…
View article: Uncovering brain tissue architecture across scales with super-resolution light microscopy
Uncovering brain tissue architecture across scales with super-resolution light microscopy Open
Mapping the complex and dense arrangement of cells and their connectivity in brain tissue demands nanoscale spatial resolution imaging. Super-resolution optical microscopy excels at visualizing specific molecules and individual cells but f…
View article: User-friendly electron microscopy protocols for the visualization of biological macromolecular complexes in three dimensions: Visualization of <i>planta</i> clathrin-coated vesicles at ultrastructural resolution
User-friendly electron microscopy protocols for the visualization of biological macromolecular complexes in three dimensions: Visualization of <i>planta</i> clathrin-coated vesicles at ultrastructural resolution Open
Biological systems are the sum of their dynamic 3-dimensional (3D) parts. Therefore, it is critical to study biological structures in 3D and at high resolutions to gain insights into their physiological functions. Electron microscopy of me…
View article: CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories
CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories Open
Mutations in the chromodomain helicase DNA-binding 8 (CHD8) gene are a frequent cause of autism spectrum disorder (ASD). While its phenotypic spectrum often encompasses macrocephaly, implicating cortical abnormalities, how CHD8 haploinsuff…
View article: Saturated reconstruction of living brain tissue
Saturated reconstruction of living brain tissue Open
Complex wiring between neurons underlies the information-processing network enabling all brain functions, including cognition and memory. For understanding how the network is structured, processes information, and changes over time, compre…
View article: Let’s Agree to Disagree on Operative versus Nonoperative (LADON) treatment for proximal humerus fractures: Study protocol for an international multicenter prospective cohort study
Let’s Agree to Disagree on Operative versus Nonoperative (LADON) treatment for proximal humerus fractures: Study protocol for an international multicenter prospective cohort study Open
Background The proximal humerus fracture is a common injury, but the optimal management is much debated. The decision for operative or nonoperative treatment is strongly influenced by patient specific factors, regional and cultural differe…
View article: Tissue-wide Effects Overrule Cell-intrinsic Gene Function in Cortical Projection Neuron Migration
Tissue-wide Effects Overrule Cell-intrinsic Gene Function in Cortical Projection Neuron Migration Open
The mammalian neocortex is composed of diverse neuronal and glial cell classes that broadly arrange in six distinct laminae. Cortical layers emerge during development and defects in the developmental programs that orchestrate cortical lami…
View article: Reference radiologic measurements for the assessment of tibial pilon fractures
Reference radiologic measurements for the assessment of tibial pilon fractures Open
Objectives: The management of pilon fractures is a challenge and the outcome depends on multiple factors, one of which is the quality of reduction. In the literature, there is no assessment of anatomical reduction in pilon fractures. We al…
View article: Tissue-Wide Effects Override Cell-Intrinsic Gene Function in Radial Neuron Migration
Tissue-Wide Effects Override Cell-Intrinsic Gene Function in Radial Neuron Migration Open
The mammalian neocortex is composed of diverse neuronal and glial cell classes that broadly arrange in six distinct laminae. Cortical layers emerge during development and defects in the developmental programs that orchestrate cortical lami…
View article: In vitro reconstitution of divisome activation
In vitro reconstitution of divisome activation Open
Bacterial cell division is coordinated by the Z-ring, a cytoskeletal structure of treadmilling filaments of FtsZ and their membrane anchors, FtsA and ZipA. For divisome maturation and initiation of constriction, the widely conserved actin-…
View article: Neurotransmitter signaling regulates distinct phases of multimodal human interneuron migration
Neurotransmitter signaling regulates distinct phases of multimodal human interneuron migration Open
Inhibitory GABAergic interneurons migrate over long distances from their extracortical origin into the developing cortex. In humans, this process is uniquely slow and prolonged, and it is unclear whether guidance cues unique to humans gove…