Markus Stein
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View article: Phylogenomic analysis and genetic mechanisms of antifungal resistance in clinical isolates of <i>Candida glabrata</i> ( <i>Nakaseomyces glabratus</i> ) from across Canada, 2013–2020
Phylogenomic analysis and genetic mechanisms of antifungal resistance in clinical isolates of <i>Candida glabrata</i> ( <i>Nakaseomyces glabratus</i> ) from across Canada, 2013–2020 Open
Candida glabrata ( Nakaseomyces glabratus ) is an important cause of invasive fungal infections and may exhibit reduced susceptibility toward antifungal drugs. Here, we used whole-genome sequencing to investigate the genomic phylogeny and …
View article: Potentially preventable? A case of recurrent blastomycosis involving the central nervous system
Potentially preventable? A case of recurrent blastomycosis involving the central nervous system Open
Background: Blastomycosis is a disease caused by infection with thermally dimorphic fungi belonging to the genus Blastomyces. Central nervous system (CNS) involvement occurs in an estimated 1% to 10% of patients with blastomycosis, and tre…
View article: What comes after the lockdown? Clustering of ANCA-associated vasculitis: single-centre observation of a spatiotemporal pattern
What comes after the lockdown? Clustering of ANCA-associated vasculitis: single-centre observation of a spatiotemporal pattern Open
Antineutrophil cytoplasm antibodies (ANCA)-associated vasculitides (AAV) are characterised by a heterogeneous clinical phenotype.1 We report a cluster of 15 patients diagnosed with AAV either de novo (n=11) or with relapsing disease (n=4) …
View article: Inhibition of polarity-regulating kinase PAR1b contributes to <i>Helicobacter pylori</i> inflicted DNA Double Strand Breaks in gastric cells
Inhibition of polarity-regulating kinase PAR1b contributes to <i>Helicobacter pylori</i> inflicted DNA Double Strand Breaks in gastric cells Open
The serine/threonine kinase Par1 is a core component of the machinery that sets up polarity in the embryo and regulates cell fate decisions but its role in the homeostasis of adult tissues is poorly understood. Inhibition of Par1 by the ba…
View article: Inhibition of polarity-regulating kinase PAR1b contributes to <i>Helicobacter pylori</i> inflicted DNA Double Strand Breaks in gastric cells
Inhibition of polarity-regulating kinase PAR1b contributes to <i>Helicobacter pylori</i> inflicted DNA Double Strand Breaks in gastric cells Open
The serine/threonine kinase Par1 is a core component of the machinery that sets up polarity in the embryo and regulates cell fate decisions but its role in the homeostasis of adult tissues is poorly understood. Inhibition of Par1 by the ba…
View article: Tolerability of inhaled N-chlorotaurine in humans: a double-blind randomized phase I clinical study
Tolerability of inhaled N-chlorotaurine in humans: a double-blind randomized phase I clinical study Open
Background: N-chlorotaurine (NCT), a long-lived oxidant produced by human leukocytes, can be synthesized chemically and used topically as a well-tolerated antiseptic to different body regions including sensitive ones. The aim of this study…
View article: Inhibition of Polarity-Regulating Kinase PAR1b contributes to <i>Helicobacter pylori</i> inflicted DNA Double Strand Breaks in Gastric Cells
Inhibition of Polarity-Regulating Kinase PAR1b contributes to <i>Helicobacter pylori</i> inflicted DNA Double Strand Breaks in Gastric Cells Open
The serine/threonine kinase Par1 is a core component of the machinery that sets up polarity in the embryo and regulates cell fate decisions but its role in the homeostasis of adult tissues is poorly understood. Inhibition of Par1 by the ba…
View article: CagA of<i>H</i><i>elicobacter pylori</i>interacts with and inhibits the serine-threonine kinase PRK2
CagA of<i>H</i><i>elicobacter pylori</i>interacts with and inhibits the serine-threonine kinase PRK2 Open
CagA is a multifunctional toxin of Helicobacter pylori that is secreted into host epithelial cells by a type IV secretion system. Following host cell translocation, CagA interferes with various host-cell signalling pathways. Most notably t…