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View article: Oberflächenthrombosen: Notfall-Crossektomie nur noch selten indiziert
Oberflächenthrombosen: Notfall-Crossektomie nur noch selten indiziert Open
Objective: The aim of this study was to assess the utilization of surgical interventions in patients diagnosed with superficial vein thrombosis (SVT) and its potential association with the occurrence of venous thromboembolism (VTE) and ble…
View article: Interventionelle Varizentherapie mittels endoluminaler Laserablation (1940 nm) bei Patienten mit Ehlers‐Danlos‐Syndromen: zwei Fallberichte
Interventionelle Varizentherapie mittels endoluminaler Laserablation (1940 nm) bei Patienten mit Ehlers‐Danlos‐Syndromen: zwei Fallberichte Open
Zusammenfassung Die chronische venöse Insuffizienz bei Patienten mit Ehlers‐Danlos‐Syndromen stellt Ärzte vor die mitunter schwierige Indikationsstellung operativer Sanierungsmaßnahmen. Durch Gefäßfragilität kommt es insbesondere bei offen…
View article: Interventional varicose vein therapy using endoluminal laser ablation (1940 nm) in patients with Ehlers‐Danlos syndromes: two case reports
Interventional varicose vein therapy using endoluminal laser ablation (1940 nm) in patients with Ehlers‐Danlos syndromes: two case reports Open
Summary In patients with Ehlers‐Danlos syndrome, the presence of chronic venous insufficiency poses a particular challenge for physicians when determining the indication for surgical treatment. Due to vascular fragility, complications such…
View article: Immunohistochemical Characterisation of the Interstitial Inflammatory Environment: T-Cell- and B-Cell-Dominant Subtypes of Hidradenitis Suppurativa
Immunohistochemical Characterisation of the Interstitial Inflammatory Environment: T-Cell- and B-Cell-Dominant Subtypes of Hidradenitis Suppurativa Open
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease with a complex immune response. Given the considerable heterogeneity of the clinical phenotype of HS, this study aimed to analyse the immunohistochemical pattern o…
View article: Medical compression stockings reduce the symptoms of obesity-associated functional venous insufficiency
Medical compression stockings reduce the symptoms of obesity-associated functional venous insufficiency Open
Background and Objectives Many overweight individuals develop obesity-associated functional venous insufficiency (OA-FVI), also known as obesity-associated dependency syndrome. This study investigates the impact of medical compression stoc…
View article: Basal Cell Carcinoma with Sarcomatoid Differentiation—A Rare Type and Its Possible Origin
Basal Cell Carcinoma with Sarcomatoid Differentiation—A Rare Type and Its Possible Origin Open
Background: We present an interesting case involving a tumour comprising both basal cell tumour cells and sarcomatoid tumour cells. An 86-year-old woman presented with an erythematous lesion on her left cheek. Clinical and dermoscopic find…
View article: Upregulated NOTCH2 Expression Is Implicated in the Clinical Aggressiveness of Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma
Upregulated NOTCH2 Expression Is Implicated in the Clinical Aggressiveness of Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma Open
Background Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) represent clinicopathological variants of a spectrum. It is known that AFX and PDS tumors harbor frequent NOTCH1/2 mutations. However, the expression of Notch sig…
View article: Immunohistochemical Expression of Haptoglobin in Skin Lesions of Hidradenitis Suppurativa
Immunohistochemical Expression of Haptoglobin in Skin Lesions of Hidradenitis Suppurativa Open
Background: Meta-inflammation is a hallmark of hidradenitis suppurativa (HS). Research on meta-inflammation in HS is growing, but there is still no research on haptoglobin as an inflammatory protein in lesional HS skin. This study examines…
View article: Efficacy of medical compression stockings class I on the reduction of symptoms in patients with uncomplicated varicose veins
Efficacy of medical compression stockings class I on the reduction of symptoms in patients with uncomplicated varicose veins Open
Summary: Background: Aim of this study was to analyze the effect of medical compression stockings (MCS) class I (according to the German classification “RAL-GZ 387”; 18–21 mmHg) on symptoms in patients with uncomplicated varicose veins (C2…
View article: S2k guideline lipedema
S2k guideline lipedema Open
Summary This S2k guideline was developed on the initiative and under the German Society of Phlebology and Lymphology (DGPL) leadership. The guideline aims to optimize the diagnosis and treatment of lipedema. It is intended to bring togethe…
View article: Excellent response to cemiplimab and radiotherapy in advanced metastatic porocarcinoma
Excellent response to cemiplimab and radiotherapy in advanced metastatic porocarcinoma Open
We present a case of excellent response to combined radiotherapy and cemiplimab in a patient with an advanced metastatic porocarcinoma. Cemiplimab is a PD-1 checkpoint inhibitor approved for the treatment of metastatic or locally advanced …
View article: Diagnosis and treatment of venous leg ulcers: S2k Guideline of the German Society of Phlebology and Lymphology (DGPL) e.V.
Diagnosis and treatment of venous leg ulcers: S2k Guideline of the German Society of Phlebology and Lymphology (DGPL) e.V. Open
Summary This S2k guideline on venous leg ulcers was created on the initiative and under the leadership of the German Society of Phlebology and Lymphology (DGPL). The guideline group also consisted of representatives from the German Society…
View article: Compression therapy in dermatology
Compression therapy in dermatology Open
Summary Compression therapy is a conservative therapy that can be used in many patients with dermatological conditions, especially those associated with edema. In addition to its well‐established use in venous and lymphatic disorders, ther…
View article: Cold Plasma Therapy in Chronic Wounds—A Multicenter, Randomized Controlled Clinical Trial (Plasma on Chronic Wounds for Epidermal Regeneration Study): Preliminary Results
Cold Plasma Therapy in Chronic Wounds—A Multicenter, Randomized Controlled Clinical Trial (Plasma on Chronic Wounds for Epidermal Regeneration Study): Preliminary Results Open
Chronic wounds (CWs) pose a significant health challenge in clinical practice. Standard wound therapy (SWT) is currently considered the gold standard. However, recent evidence suggests that cold plasma therapy (CPT) holds promise for impro…
View article: Endovenöse Laserablation vs. Crossektomie und Stripping-Operation: Welche Methode gewinnt im 10-Jahres-Vergleich?
Endovenöse Laserablation vs. Crossektomie und Stripping-Operation: Welche Methode gewinnt im 10-Jahres-Vergleich? Open
Objective: The long-term results of saphenofemoral ligation and stripping (SFL/S) were compared with 980-nm bare fiber endovenous laser ablation (EVLA) for the treatment of great saphenous vein (GSV) incompetence. Methods: This was a singl…
View article: Factors influencing superficial and deep vein thrombosis after foam sclerotherapy in varicose veins
Factors influencing superficial and deep vein thrombosis after foam sclerotherapy in varicose veins Open
Summary Background Side effects of foam sclerotherapy for varicose veins can include both deep (DVT) and superficial leg vein thrombosis (SVT). The risk factors that favor the development of SVT or DVT after foam sclerotherapy are still la…
View article: Impact of a synchronous prophylactic treatment of the anterior accessory saphenous vein on the recurrent varicose vein rate in patients undergoing thermal ablation of an insufficient great saphenous vein (SYNCHRONOUS-Study): study protocol for a prospective, multicentre, controlled observational study
Impact of a synchronous prophylactic treatment of the anterior accessory saphenous vein on the recurrent varicose vein rate in patients undergoing thermal ablation of an insufficient great saphenous vein (SYNCHRONOUS-Study): study protocol for a prospective, multicentre, controlled observational study Open
Introduction To date, there are no prospective studies evaluating the prevention of recurrent veins by the simultaneous treatment of a sufficient anterior accessory saphenous vein (AASV) in patients undergoing endovenous laser ablation (EV…
View article: Undifferentiated pleomorphic sarcoma of the breast with neoplastic fever: case report and genomic characterization
Undifferentiated pleomorphic sarcoma of the breast with neoplastic fever: case report and genomic characterization Open
Purpose Primary breast sarcomas are extraordinary rare, in particular undifferentiated pleomorphic sarcoma (UPS). UPS with neoplastic fever (UPS-NF) of the breast has not been reported yet. Here, we present an extended UPS-NF of the breast…
View article: Antibody-Negative Paraneoplastic Autoimmune Multiorgan Syndrome (PAMS) in a Patient with Follicular Lymphoma Accompanied by an Excess of Peripheral Blood CD8+ Lymphocytes
Antibody-Negative Paraneoplastic Autoimmune Multiorgan Syndrome (PAMS) in a Patient with Follicular Lymphoma Accompanied by an Excess of Peripheral Blood CD8+ Lymphocytes Open
Paraneoplastic autoimmune multiorgan syndrome (PAMS) is a life-threatening autoimmune disease associated with malignancies. Here, we present a patient initially misdiagnosed with “chronic” Stevens–Johnson syndrome. Over a year later, the p…
View article: Ulcus cruris venosum: Allogene Stammzelltransplantation bietet vielversprechenden Therapieansatz
Ulcus cruris venosum: Allogene Stammzelltransplantation bietet vielversprechenden Therapieansatz Open
A significant number of chronic venous ulcers (CVUs) fail to heal despite of guideline-conform standard of care. Skin-derived ABCB5+ mesenchymal stem cells (MSCs) can dampen the sustained IL-1β-driven inflammation present in chronic wounds…
View article: Waiving Subsequent Complete Lymph Node Dissection in Melanoma Patients with Positive Sentinel Lymph Node Does Not Result in Worse Outcome on 20-Year Analysis
Waiving Subsequent Complete Lymph Node Dissection in Melanoma Patients with Positive Sentinel Lymph Node Does Not Result in Worse Outcome on 20-Year Analysis Open
Complete lymph node dissection (CLND) following positive sentinel lymph node (SLN) biopsy has been the standard of care for decades. We aimed to study melanoma patients with an emphasis on the outcome of patients with versus without CLND f…
View article: Cutaneous findings following COVID‐19 vaccination: review of world literature and own experience
Cutaneous findings following COVID‐19 vaccination: review of world literature and own experience Open
There is growing evidence that not only the novel coronavirus disease (COVID‐19) but also the COVID‐19 vaccines can cause a variety of skin reactions. In this review article, we provide a brief overview on cutaneous findings that have been…
View article: Comparison of mutation profiles in primary melanomas and corresponding nodal naevi using next‐generation sequencing
Comparison of mutation profiles in primary melanomas and corresponding nodal naevi using next‐generation sequencing Open
Based on our data, it seems that NN descend from previously UV-exposed BRAF wildtype cutaneous melanocytes, rather than from primary MM or arrested progenitor cells.
View article: Expression of Mismatch Repair Proteins in Merkel Cell Carcinoma
Expression of Mismatch Repair Proteins in Merkel Cell Carcinoma Open
We aimed to assess for the first time the mismatch repair (MMR) protein expression in Merkel cell carcinoma (MCC). Immunohistochemistry was performed for MLH1, MSH2, MSH6, and PMS2 on patients’ tumor tissue (n = 56), including neighbored h…
View article: Functional repair of the great saphenous vein by external valvuloplasty reduces the vein's diameter: 6-month results of a multicentre study
Functional repair of the great saphenous vein by external valvuloplasty reduces the vein's diameter: 6-month results of a multicentre study Open
Objectives External valvuloplasty (eVP) is a reconstructive surgical method to repair the function of the terminal and preterminal valves. We evaluated the 6-month outcomes of eVP regarding the diameter of the great saphenous vein (GSV). M…
View article: Expression of Hedgehog signalling molecules in microcystic adnexal carcinoma
Expression of Hedgehog signalling molecules in microcystic adnexal carcinoma Open
Our results indicate that alterations of the HH signalling are unlikely to play a major role in the pathogenesis of MAC, which is in contrast to the morphologically similar BCC and TE. Our observation provides additional information to the…