Markus W. Germann
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View article: Conserved Sequences from Dengue Virus Genomes Form Stable G-Quadruplexes
Conserved Sequences from Dengue Virus Genomes Form Stable G-Quadruplexes Open
Arthropod-borne members of the genus Orthoflavivirus cause significant human disease. Four serotypes of dengue virus are endemic globally, and approximately 50 percent of the world's population lives in a dengue-affected area. Compl…
View article: Structure of an RNA G-quadruplex from the West Nile virus genome
Structure of an RNA G-quadruplex from the West Nile virus genome Open
View article: Supplementary Figure 3 from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis
Supplementary Figure 3 from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis Open
Supplementary Figure 3. MybPlt4 exacerbates hematopoietic defects in ApcMin/+ mice.
View article: Supplementary Figure 3 from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis
Supplementary Figure 3 from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis Open
Supplementary Figure 3. MybPlt4 exacerbates hematopoietic defects in ApcMin/+ mice.
View article: Supplementary Figure 2 from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis
Supplementary Figure 2 from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis Open
Supplementary Figure 2. Myb, TCF-4, and E2F-1 binding sites identified within the human CCNE1 promoter region.
View article: Supplementary Figure 1 from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis
Supplementary Figure 1 from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis Open
Supplementary Figure 1. Myb, TCF-4, and E2F-1 binding sites identified within the murine Cyclin E1 promoter region.
View article: Data from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis
Data from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis Open
Cyclin E1 is essential for the reentry of quiescent cells into the cell cycle. When hypomorphic mutant Myb mice (MybPlt4) were examined, it was noted that Cyclin E1 (Ccne1) expression was reduced. Furthermore, the …
View article: Supplementary Figure 2 from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis
Supplementary Figure 2 from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis Open
Supplementary Figure 2. Myb, TCF-4, and E2F-1 binding sites identified within the human CCNE1 promoter region.
View article: Supplementary Figure Legends from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis
Supplementary Figure Legends from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis Open
Supplementary Figure Legends
View article: Supplementary Figure 1 from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis
Supplementary Figure 1 from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis Open
Supplementary Figure 1. Myb, TCF-4, and E2F-1 binding sites identified within the murine Cyclin E1 promoter region.
View article: Data from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis
Data from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis Open
Cyclin E1 is essential for the reentry of quiescent cells into the cell cycle. When hypomorphic mutant Myb mice (MybPlt4) were examined, it was noted that Cyclin E1 (Ccne1) expression was reduced. Furthermore, the …
View article: Supplementary Figure Legends from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis
Supplementary Figure Legends from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis Open
Supplementary Figure Legends
View article: Supplementary Table 2 from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer
Supplementary Table 2 from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer Open
PDF file, 46K, Analysis of the expression of ALDH specific isoforms in BPH and PCa surgical specimens.
View article: Data from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer
Data from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer Open
Purpose: High aldehyde dehydrogenase (ALDH) has been suggested to selectively mark cells with high tumorigenic potential in established prostate cancer cell lines. However, the existence of cells with high ALDH activity (ALDHbr…
View article: Supplementary Materials and Methods from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer
Supplementary Materials and Methods from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer Open
PDF file, 41K.
View article: Supplementary Table 1 from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer
Supplementary Table 1 from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer Open
PDF file, 39K, Characteristics of PCa patients.
View article: Supplementary Table 1 from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer
Supplementary Table 1 from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer Open
PDF file, 39K, Characteristics of PCa patients.
View article: Supplementary Table 2 from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer
Supplementary Table 2 from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer Open
PDF file, 46K, Analysis of the expression of ALDH specific isoforms in BPH and PCa surgical specimens.
View article: Supplementary Figure 1 from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer
Supplementary Figure 1 from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer Open
PDF file, 1824K, Differential expression and localization of ALDH1A1 and ALDH7A1 proteins in BPH.
View article: Supplementary Figure 1 from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer
Supplementary Figure 1 from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer Open
PDF file, 1824K, Differential expression and localization of ALDH1A1 and ALDH7A1 proteins in BPH.
View article: Supplementary Figure 2 from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer
Supplementary Figure 2 from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer Open
PDF file, 3314K, Representative IHC analysis of ALDH1A1 expression in large tissues prostate sections.
View article: Data from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer
Data from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer Open
Purpose: High aldehyde dehydrogenase (ALDH) has been suggested to selectively mark cells with high tumorigenic potential in established prostate cancer cell lines. However, the existence of cells with high ALDH activity (ALDHbr…
View article: Supplementary Materials and Methods from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer
Supplementary Materials and Methods from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer Open
PDF file, 41K.
View article: Supplementary Figure 2 from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer
Supplementary Figure 2 from Characterization and Clinical Relevance of ALDH<sup>bright</sup> Populations in Prostate Cancer Open
PDF file, 3314K, Representative IHC analysis of ALDH1A1 expression in large tissues prostate sections.
View article: Editorial: Crosstalk between innate and adaptive immunity in colorectal cancer: Implications for immunotherapy
Editorial: Crosstalk between innate and adaptive immunity in colorectal cancer: Implications for immunotherapy Open
International audience
View article: Understanding Integrase-DNA Interactions in Retroviruses Through 3'-processing
Understanding Integrase-DNA Interactions in Retroviruses Through 3'-processing Open
Retroviral integrase is one of the key enzymes needed to integrate viral DNA into a host cell?s genome for many retroviruses including HIV. Integrase?s role is three-fold. It prepares the ends of the DNA so that they can successfully bind …
View article: Self-Consistent Parameterization of DNA Residues for the Non-Polarizable AMBER Force Fields
Self-Consistent Parameterization of DNA Residues for the Non-Polarizable AMBER Force Fields Open
Fixed-charge (non-polarizable) forcefields are accurate and computationally efficient tools for modeling the molecular dynamics of nucleic acid polymers, particularly DNA, well into the µs timescale. The continued utility of these forcefie…
View article: Intrinsic disorder controls two functionally distinct dimers of the master transcription factor PU.1
Intrinsic disorder controls two functionally distinct dimers of the master transcription factor PU.1 Open
Distinct dimeric forms of PU.1 mutually antagonize to control the transcriptionally active dose via a disordered PEST domain.
View article: Intrinsic Disorder Directs Two Distinct Dimers of the Master Transcription Factor PU.1
Intrinsic Disorder Directs Two Distinct Dimers of the Master Transcription Factor PU.1 Open
View article: Second Generation G-Quadruplex Stabilizing Trimethine Cyanines
Second Generation G-Quadruplex Stabilizing Trimethine Cyanines Open
G-quadruplex DNA has been recognized as a highly appealing target for the development of new selective chemotherapeutics, which could result in markedly reduced toxicity towards normal cells. In particular, the cyanine dyes that bind selec…