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View article: Effect on Syndecan-1 and Hyaluronan Levels Depending on Multiple Organ Failure, Coagulopathy and Survival: An Observational Study in Major Trauma Patients
Effect on Syndecan-1 and Hyaluronan Levels Depending on Multiple Organ Failure, Coagulopathy and Survival: An Observational Study in Major Trauma Patients Open
Background: Major trauma, as well as traumatic hemorrhagic shock go along with early damage to the endothelial glycocalyx (EG). Shed glycocalyx constituents can activate the innate immune system and aggravate secondary injury. Subsequently…
View article: Rabies post-exposure prophylaxis in the emergency department: A monocentric retrospective observational study
Rabies post-exposure prophylaxis in the emergency department: A monocentric retrospective observational study Open
Our data show that patients frequently present for R-PEP in ED. Therefore, there is a high need for education on indication for R-PEP and for implementation of precise R-PEP treatment guidelines in daily clinical practice.
View article: Characteristics of patients who were admitted to the intensive care unit through the emergency department: a monocentric retrospective observational study
Characteristics of patients who were admitted to the intensive care unit through the emergency department: a monocentric retrospective observational study Open
Background The intensive care of critically ill patients is of great importance for emergency care. To achieve this, patients in need of intensive care must be quickly identified. On the other hand, misallocation of intensive care beds to …
View article: The Tyrosine Phosphatase SHP-1 Regulates Hypoxia Inducible Factor-1α (HIF-1α) Protein Levels in Endothelial Cells under Hypoxia
The Tyrosine Phosphatase SHP-1 Regulates Hypoxia Inducible Factor-1α (HIF-1α) Protein Levels in Endothelial Cells under Hypoxia Open
SHP-1 decreases half-life of HIF-1α under hypoxic conditions resulting in decreased cell growth due to diminished VEGF synthesis and secretion. The regulatory effect of SHP-1 on HIF-1α stability may be mediated by inhibition of endothelial…