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View article: Peptide inhibition of acute lung injury in a novel two-hit rat model
Peptide inhibition of acute lung injury in a novel two-hit rat model Open
Acute lung injury (ALI) often causes severe trauma that may progress to significant morbidity and mortality. ALI results from a combination of the underlying clinical condition of the patient (e.g., inflammation) with a secondary insult su…
View article: RLS-0071 Inhibits Acute Lung Injury in a Novel 2-Hit Model
RLS-0071 Inhibits Acute Lung Injury in a Novel 2-Hit Model Open
Rationale: Acute lung injury (ALI) is often a complication of viral infection (SARS-CoV-2, Influenza, RSV) that leads to significant morbidity and mortality.A novel rat two-hit ALI model was developed that uses a complement stimulus for th…
View article: Incompatible erythrocyte transfusion with lipopolysaccharide induces acute lung injury in a novel rat model
Incompatible erythrocyte transfusion with lipopolysaccharide induces acute lung injury in a novel rat model Open
Acute transfusion reactions can manifest in many forms including acute hemolytic transfusion reaction, allergic reaction and transfusion-related acute lung injury. We previously developed an acute hemolytic transfusion reaction rat model m…
View article: Membrane channel gene expression in human costal and articular chondrocytes
Membrane channel gene expression in human costal and articular chondrocytes Open
Chondrocytes are the uniquely resident cells found in all types of cartilage and key to their function is the ability to respond to mechanical loads with changes of metabolic activity. This mechanotransduction property is, in part, mediate…