Markus Zojer
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Cdk6’s functions are critically regulated by its unique C-terminus Open
The vital cell cycle machinery is tightly regulated and alterations of its central signaling hubs are a hallmark of cancer. The activity of CDK6 is controlled by interaction with several partners including cyclins and INK4 proteins, which …
View article: Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells
Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells Open
Hematopoietic stem cells (HSCs) are characterized by the ability to self-renew and to replenish the hematopoietic system. The cell-cycle kinase cyclin-dependent kinase 6 (CDK6) regulates transcription, whereby it has both kinase-dependent …
View article: Genome Dynamics and Temperature Adaptation During Experimental Evolution of Obligate Intracellular Bacteria
Genome Dynamics and Temperature Adaptation During Experimental Evolution of Obligate Intracellular Bacteria Open
Evolution experiments with free-living microbes have radically improved our understanding of genome evolution and how microorganisms adapt. Yet there is a paucity of such research focusing on strictly host-associated bacteria, even though …
P452: THE INTERACTOME OF CDK6 IN DIFFERENT ONCOGENIC CONTEXTS Open
Background: The mammalian cell cycle is controlled by a complex signaling network that is frequently deregulated in cancer. Cyclin-dependent kinases (CDKs) are the key players in governing cell cycle progression. CDK6 and its close homolog…
P325: A KINASE-DEAD VARIANT OF CDK6 IS ASSOCIATED WITH REDUCED TUMORIGENIC POTENTIAL AND A DISTINCT TRANSCRIPTIONAL REWIRING IN AN ALL MODEL Open
Background: The cell cycle kinase Cdk6 is a major regulator of cell cycle progression from G1 to S phase. Cdk4/6 kinase inhibitors are approved for the treatment of breast cancer and show promising results in pre-clinical studies of other …
P453: CDK6 DEGRADATION IS IMPEDED BY P16INK4A AND P18INK4C IN AML Open
Background: Acute myeloid leukemia (AML) is a highly aggressive disease that comprises a heterogeneous group of genetically distinct subtypes. AML is initiated by leukemic cells, which are able to self-renew and give rise to malignant myel…
CDK6 Degradation Is Counteracted by p16INK4A and p18INK4C in AML Open
Cyclin-dependent kinase 6 (CDK6) represents a novel therapeutic target for the treatment of certain subtypes of acute myeloid leukaemia (AML). CDK4/6 kinase inhibitors have been widely studied in many cancer types and their effects may be …
A robust approach for the generation of functional hematopoietic progenitor cell lines to model leukemic transformation Open
Studies of molecular mechanisms of hematopoiesis and leukemogenesis are hampered by the unavailability of progenitor cell lines that accurately mimic the situation in vivo. We now report a robust method to generate and maintain LSK (Lin−, …
A cutting-edge approach unravels a novel role for CDK6 in leukemic progenitor cells Open
Studies of molecular mechanisms of hematopoiesis and leukemogenesis are hampered by the unavailability of progenitor cell lines that accurately mimic the situation in vivo . We now report a robust method to generate and maintain LSK (lin -…
Molecular causes of an evolutionary shift along the parasitism–mutualism continuum in a bacterial symbiont Open
Significance Symbiotic relationships with microbes are ubiquitous among living beings and can be parasitic, such as in bacterial pathogens, or mutualistic, as in beneficial microbiomes. Among other factors, the outcome of microbe–host rela…
The interplay of CDK4 and CDK6 in melanoma Open
The cyclin-dependent kinases CDK4 and CDK6 promote progression through the cell cycle, where their functions are considered to be redundant. Recent studies have identified an additional role for CDK6 in the transcriptional regulation of ca…
View article: CDK6 coordinates JAK2V617F mutant MPN via NF-κB and apoptotic networks
CDK6 coordinates JAK2V617F mutant MPN via NF-κB and apoptotic networks Open
Over 80% of patients with myeloproliferative neoplasms (MPNs) harbor the acquired somatic JAK2V617F mutation. JAK inhibition is not curative and fails to induce a persistent response in most patients, illustrating the need for the developm…
Therapeutic Vulnerabilities in FLT3-Mutant AML Unmasked by Palbociclib Open
While significant progress has been made in the treatment of acute myeloid leukemia (AML), not all patients can be cured. Mutated in about 1/3 of de novo AML, the FLT3 receptor tyrosine kinase is an attractive target for drug development, …
CDK6 Antagonizes p53-Induced Responses during Tumorigenesis Open
Tumor formation is a multistep process during which cells acquire genetic and epigenetic changes until they reach a fully transformed state. We show that CDK6 contributes to tumor formation by regulating transcriptional responses in a stag…
Variant profiling of evolving prokaryotic populations Open
Genomic heterogeneity of bacterial species is observed and studied in experimental evolution experiments and clinical diagnostics, and occurs as micro-diversity of natural habitats. The challenge for genome research is to accurately captur…
Peer Review #1 of "Variant profiling of evolving prokaryotic populations (v0.2)" Open
Genomic heterogeneity of bacterial species is observed and studied in experimental evolution experiments, clinical diagnostics and occurs as micro-diversity of natural habitats.The challenge for genome research is to accurately capture thi…
Genotyping of evolving prokaryotic populations Open
Genomic heterogeneity of bacterial species is observed and studied in experimental evolution experiments, clinical diagnostics and occurs as micro-diversity of natural habitats. The challenge for genome research is to accurately capture th…
Genotyping of evolving prokaryotic populations Open
Genomic heterogeneity of bacterial species is observed and studied in experimental evolution experiments, clinical diagnostics and occurs as micro-diversity of natural habitats. The challenge for genome research is to accurately capture th…