Marla E. Tharp
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View article: The inactive X chromosome drives sex differences in microglial inflammatory activity in human glioblastoma
The inactive X chromosome drives sex differences in microglial inflammatory activity in human glioblastoma Open
Whether an individual is a biological female or male affects cancer risk, but the responsible mechanisms and cell types remain obscure. Glioblastoma multiforme (GBM) is a male-biased cancer that is highly aggressive, and resistant to treat…
View article: 984 Using sex differences to uncover novel microglia regulators of glioblastoma progression
984 Using sex differences to uncover novel microglia regulators of glioblastoma progression Open
Background Glioblastoma Multiforme (GBM) is the most aggressive and treatment-resistant brain tumor. GBM progression is heavily influenced by non-malignant microglia, the brain resident macrophages, that get coerced into a symbiotic relati…
View article: Tumor susceptibility gene-101 regulates glucocorticoid receptor through disorder-mediated allostery
Tumor susceptibility gene-101 regulates glucocorticoid receptor through disorder-mediated allostery Open
Tumor Susceptibility Gene-101 (TSG101) is involved in endosomal maturation and has been implicated in the transcriptional regulation of several steroid hormone receptors (SHRs), although a detailed characterization of such regulation has y…
View article: Evading non-essential fetal oocyte attrition maximizes the ovarian reserve
Evading non-essential fetal oocyte attrition maximizes the ovarian reserve Open
Female reproductive success depends on the size and quality of a finite ovarian reserve. Paradoxically, mammals such as mice and humans eliminate up to 80% of the initial oocyte pool during development through the enigmatic process of feta…
View article: Fluorescent Cell Staining Methods for Living <i>Hypsibius exemplaris</i> Embryos
Fluorescent Cell Staining Methods for Living <i>Hypsibius exemplaris</i> Embryos Open
The tardigrade Hypsibius exemplaris was chosen as a model system in part because animals and embryos are optically clear at all stages, facilitating the visualization of events in living material. Here we report new methods for introducing…
View article: A Whole-Mount Approach for Accurate Quantitative and Spatial Assessment of Fetal Oocyte Dynamics in Mice1
A Whole-Mount Approach for Accurate Quantitative and Spatial Assessment of Fetal Oocyte Dynamics in Mice1 Open
Depletion of oocytes from the embryonic ovary is a key feature of mammalian oogenesis; however, the rational and molecular bases for this phenomenon remain poorly understood. Presently in the field, the most systematic analysis used to und…