Marla Gearing
YOU?
Author Swipe
View article: Metabolic dysregulation in Alzheimer's disease: A brain metabolomics approach
Metabolic dysregulation in Alzheimer's disease: A brain metabolomics approach Open
INTRODUCTION This study aimed to identify specific biological pathways and molecules involved in Alzheimer's disease (AD) neuropathology. METHODS We conducted cutting‐edge high‐resolution metabolomics profiling of 162 human frontal cortex …
View article: Formic acid impairs α-synuclein seeding activity in human and mouse brains
Formic acid impairs α-synuclein seeding activity in human and mouse brains Open
α-Synuclein (α-syn) is an abundant monomeric protein that can aggregate into fibrils and form neuropathological inclusions in the brains of patients with synucleinopathies. New evidence suggests that the mouse-human transmission barrier of…
View article: Exploring potential mechanisms of an African protective locus for Alzheimer's disease in <i>APOEε4</i> carriers
Exploring potential mechanisms of an African protective locus for Alzheimer's disease in <i>APOEε4</i> carriers Open
INTRODUCTION We recently described that the African‐specific A allele of rs10423769, which lies in an area of segmental duplications, reduces Alzheimer's disease (AD) risk by ∼ 75% in apolipoprotein E ( APOE) ε4 homozygotes. METHODS Short …
View article: Multiplex digital spatial profiling identifies subregion dependent targeted proteome changes across variants of dementia
Multiplex digital spatial profiling identifies subregion dependent targeted proteome changes across variants of dementia Open
Frontotemporal lobar degeneration (FTLD) is the leading cause of dementia in patients under the age of 65. Even in a single anatomical region, there is variance within pathological protein deposition within the FTLD spectrum, which drives …
View article: Copy Number Variation and Haplotype Analysis of <scp>17q21.31</scp> Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells
Copy Number Variation and Haplotype Analysis of <span>17q21.31</span> Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells Open
Background The 17q21.31 region with various structural forms characterized by the H1/H2 haplotypes and three large copy number variations (CNVs) represents the strongest risk locus in progressive supranuclear palsy (PSP). Objective To inve…
View article: pTDP-43 levels correlate with cell type–specific molecular alterations in the prefrontal cortex of <i>C9orf72</i> ALS/FTD patients
pTDP-43 levels correlate with cell type–specific molecular alterations in the prefrontal cortex of <i>C9orf72</i> ALS/FTD patients Open
Repeat expansions in the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis and familial frontotemporal dementia (ALS/FTD). To identify molecular defects that take place in the dorsolateral frontal cortex of pa…
View article: Harnessing chromatin loops to identify susceptibility genes in different populations for Alzheimer’s disease: rs3851179 links to <i>PICALM</i> not <i>EED</i>
Harnessing chromatin loops to identify susceptibility genes in different populations for Alzheimer’s disease: rs3851179 links to <i>PICALM</i> not <i>EED</i> Open
Background Annotation of target genes of non‐coding GWAS loci remains a challenge since 1) regulatory elements identified by GWAS can be metabases away from its actual target, 2) one regulatory element can target multiple genes, and 3) mul…
View article: Proteomic Analysis Resolves Distinct Molecular Signatures in Alzheimer’s Disease Brain Across Diverse Racial Groups
Proteomic Analysis Resolves Distinct Molecular Signatures in Alzheimer’s Disease Brain Across Diverse Racial Groups Open
Background Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, yet our comprehension predominantly relies on studies within the non‐Hispanic White (NHW) population. To address this, Accelerating Medicines Partnership …
View article: Local ancestry in Apoe3: Friend or Foe?
Local ancestry in Apoe3: Friend or Foe? Open
Background Non‐Hispanic White APOE4 carriers have a higher risk of developing AD compared to African American APOE4 carriers. The local ancestry (LA) surrounding the APOE region was previously shown to be the primary factor in this risk di…
View article: Large‐scale deep proteomic analysis in Alzheimer's disease brain regions across race and ethnicity
Large‐scale deep proteomic analysis in Alzheimer's disease brain regions across race and ethnicity Open
INTRODUCTION Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, yet our comprehension predominantly relies on studies within non‐Hispanic White (NHW) populations. Here we provide an extensive survey of the proteomic …
View article: Transcriptome-wide association study of Alzheimer disease reveals many differentially expressed genes and multiple biological pathways in brain tissue from African American donors
Transcriptome-wide association study of Alzheimer disease reveals many differentially expressed genes and multiple biological pathways in brain tissue from African American donors Open
Background The genetic basis of Alzheimer disease (AD) in African American (AA) individuals is much less well understood than in European-ancestry (EA) individuals. Furthermore, relatively few AA donors have been included in postmortem AD …
View article: African origin haplotype protective for Alzheimer’s disease in<i>APOE</i>ε4 carriers: exploring potential mechanisms
African origin haplotype protective for Alzheimer’s disease in<i>APOE</i>ε4 carriers: exploring potential mechanisms Open
APOE ε4 is the strongest genetic risk factor for Alzheimer’s disease (AD) with approximately 50% of AD patients carrying at least one APOE ε4 allele. Our group identified a protective interaction between APOE ε4 with the African-specific A…
View article: Amyloid-β predominant Alzheimer’s disease neuropathologic change
Amyloid-β predominant Alzheimer’s disease neuropathologic change Open
Different subsets of Alzheimer’s disease neuropathologic change (ADNC), including the intriguing set of individuals with severe/widespread amyloid-β (Aβ) plaques but no/mild tau tangles [Aβ-predominant (AP)-ADNC], may have distinct genetic…
View article: Correction: Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy
Correction: Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy Open
Background: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and oligodendrocytes. Previous genome-wide association studies for PS…
View article: Correction: Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease
Correction: Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease Open
View article: Bridging the gap: Multi‐omics profiling of brain tissue in Alzheimer's disease and older controls in multi‐ethnic populations
Bridging the gap: Multi‐omics profiling of brain tissue in Alzheimer's disease and older controls in multi‐ethnic populations Open
INTRODUCTION Multi‐omics studies in Alzheimer's disease (AD) revealed many potential disease pathways and therapeutic targets. Despite their promise of precision medicine, these studies lacked Black Americans (BA) and Latin Americans (LA),…
View article: Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy
Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy Open
Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and oligodendrocytes. Previous genome-wide association studies for PSP…
View article: Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease
Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease Open
Lewy body dementia (LBD), a class of disorders comprising Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB), features substantial clinical and pathological overlap with Alzheimer’s disease (AD). The identification of b…
View article: Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing
Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing Open
Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) is a fatal neurodegenerative disorder with only a limited number of risk loci identified. We report our comprehensive genome-wide assoc…
View article: Large-scale Deep Proteomic Analysis in Alzheimer’s Disease Brain Regions Across Race and Ethnicity
Large-scale Deep Proteomic Analysis in Alzheimer’s Disease Brain Regions Across Race and Ethnicity Open
Introduction Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease, yet our comprehension predominantly relies on studies within the non-Hispanic White (NHW) population. Here we aimed to provide comprehensive insights in…
View article: The association between neighborhood deprivation and DNA methylation in an autopsy cohort
The association between neighborhood deprivation and DNA methylation in an autopsy cohort Open
Previous research has found that living in a disadvantaged neighborhood is associated with poor health outcomes. Living in disadvantaged neighborhoods may alter inflammation and immune response in the body, which could be reflected in epig…
View article: Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer’s Disease and Older Controls in Multi-Ethnic Populations
Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer’s Disease and Older Controls in Multi-Ethnic Populations Open
INTRODUCTION Multi-omics studies in Alzheimer’s disease (AD) revealed many potential disease pathways and therapeutic targets. Despite their promise of precision medicine, these studies lacked African Americans (AA) and Latin Americans (LA…
View article: MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study
MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study Open
Wellcome Trust, Rotha Abraham Trust, Brain Research UK, the Dolby Fund, Dementia Research Institute (Medical Research Council), US National Institutes of Health, and the Mayo Clinic Foundation.
View article: Vascular Heparan Sulfate and Amyloid-β in Alzheimer’s Disease Patients
Vascular Heparan Sulfate and Amyloid-β in Alzheimer’s Disease Patients Open
Alzheimer’s disease (AD) is a debilitating neurodegenerative disease characterized by the accumulation of extracellular amyloid-β peptides (Aβ) within the cerebral parenchyma and vasculature, which is known as cerebral amyloid angiopathy (…
View article: Association of Structural Forms of 17q21.31 with the Risk of Progressive Supranuclear Palsy and<i>MAPT</i>Sub-haplotypes
Association of Structural Forms of 17q21.31 with the Risk of Progressive Supranuclear Palsy and<i>MAPT</i>Sub-haplotypes Open
Importance The chromosome 17q21.31 region, containing a 900 Kb inversion that defines H1 and H2 haplotypes, represents the strongest genetic risk locus in progressive supranuclear palsy (PSP). In addition to H1 and H2, various structural f…
View article: Differential DNA methylation in the brain as potential mediator of the association between traffic‐related PM<sub>2.5</sub> and neuropathology markers of Alzheimer's disease
Differential DNA methylation in the brain as potential mediator of the association between traffic‐related PM<sub>2.5</sub> and neuropathology markers of Alzheimer's disease Open
INTRODUCTION Growing evidence indicates that fine particulate matter (PM 2.5 ) is a risk factor for Alzheimer's disease (AD), but the underlying mechanisms have been insufficiently investigated. We hypothesized differential DNA methylation…
View article: Vascular Heparan Sulfate and Amyloid-β in Alzheimer’s Disease Patients
Vascular Heparan Sulfate and Amyloid-β in Alzheimer’s Disease Patients Open
Alzheimer’s Disease (AD) is a debilitating neurodegenerative disease characterized by the accumulation of extracellular amyloid-β peptides (Aβ) within the cerebral parenchyma and vasculature, the latter termed cerebral amyloid angiopathy (…
View article: Network Proteomics of the Lewy Body Dementia Brain Reveals Presynaptic Signatures Distinct from Alzheimer’s Disease
Network Proteomics of the Lewy Body Dementia Brain Reveals Presynaptic Signatures Distinct from Alzheimer’s Disease Open
Lewy body dementia (LBD), a class of disorders comprising Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB), features substantial clinical and pathological overlap with Alzheimer’s disease (AD). The identification of b…
View article: Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy
Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy Open
Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and oligodendrocytes. Previous genome-wide association studies for PSP…
View article: Toward a generalizable machine learning workflow for neurodegenerative disease staging with focus on neurofibrillary tangles
Toward a generalizable machine learning workflow for neurodegenerative disease staging with focus on neurofibrillary tangles Open