Marla J. Berry
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View article: Cardiac redox imbalance upon disruption of selenocysteine decomposition in mice
Cardiac redox imbalance upon disruption of selenocysteine decomposition in mice Open
Global loss of selenocysteine lyase controls the glutathione system in the heart, impacting glutathione peroxidase protein levels and activity, and glutathione levels in a mouse model of obesity. Loss of selenocysteine lyase and selenometh…
View article: Health Disparities Investigator Development through a Team-Science Pilot Projects Program
Health Disparities Investigator Development through a Team-Science Pilot Projects Program Open
Profound health disparities are widespread among Native Hawaiians, other Pacific Islanders, and Filipinos in Hawai‘i. Efforts to reduce and eliminate health disparities are limited by a shortage of investigators trained in addressing the g…
View article: Prolonged maternal exposure to glucocorticoids alters selenoprotein expression in the developing brain
Prolonged maternal exposure to glucocorticoids alters selenoprotein expression in the developing brain Open
Aberrant activation of the stress-response system in early life can alter neurodevelopment and cause long-term neurological changes. Activation of the hypothalamic–pituitary–adrenal axis releases glucocorticoids into the bloodstream, to he…
View article: Selenium Protects Mouse Hypothalamic Cells from Glucocorticoid-Induced Endoplasmic Reticulum Stress Vulnerability and Insulin Signaling Impairment
Selenium Protects Mouse Hypothalamic Cells from Glucocorticoid-Induced Endoplasmic Reticulum Stress Vulnerability and Insulin Signaling Impairment Open
The use of glucocorticoid medications is known to cause metabolic side effects such as overeating, excess weight gain, and insulin resistance. The hypothalamus, a central regulator of feeding behavior and energy expenditure, is highly resp…
View article: Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication
Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication Open
The ability of the body to maintain homeostasis requires constant communication between the brain and peripheral tissues. Different organs produce signals, often in the form of hormones, which are detected by the hypothalamus. In response,…
View article: Female Mice with Selenocysteine tRNA Deletion in Agrp Neurons Maintain Leptin Sensitivity and Resist Weight Gain While on a High-Fat Diet
Female Mice with Selenocysteine tRNA Deletion in Agrp Neurons Maintain Leptin Sensitivity and Resist Weight Gain While on a High-Fat Diet Open
The role of the essential trace element selenium in hypothalamic physiology has begun to come to light over recent years. Selenium is used to synthesize a family of proteins participating in redox reactions called selenoproteins, which con…
View article: Sex-Specific Metabolic Impairments in a Mouse Model of Disrupted Selenium Utilization
Sex-Specific Metabolic Impairments in a Mouse Model of Disrupted Selenium Utilization Open
The essential micronutrient selenium (Se) provides antioxidant defense and supports numerous biological functions. Obtained through dietary intake, Se is incorporated into selenoproteins via the amino acid, selenocysteine (Sec). Mice with …
View article: Stress and the Brain: An Emerging Role for Selenium
Stress and the Brain: An Emerging Role for Selenium Open
The stress response is an important tool in an organism’s ability to properly respond to adverse environmental conditions in order to survive. Intense acute or chronic elevation of glucocorticoids, a class of stress hormone, can have delet…
View article: Building a Diverse Workforce and Thinkforce to Reduce Health Disparities
Building a Diverse Workforce and Thinkforce to Reduce Health Disparities Open
The Research Centers in Minority Institutions (RCMI) Program was congressionally mandated in 1985 to build research capacity at institutions that currently and historically recruit, train, and award doctorate degrees in the health professi…
View article: The Deiodinases: Their Identification and Cloning of Their Genes
The Deiodinases: Their Identification and Cloning of Their Genes Open
In this minireview, we provide a historical outline of the events that led to the identification and characterization of the deiodinases, the recognition that deiodination plays a major role in thyroid hormone action, and the cloning of th…
View article: Adaptive Thermogenesis in a Mouse Model Lacking Selenoprotein Biosynthesis in Brown Adipocytes
Adaptive Thermogenesis in a Mouse Model Lacking Selenoprotein Biosynthesis in Brown Adipocytes Open
Selenoproteins are a class of proteins with the selenium-containing amino acid selenocysteine (Sec) in their primary structure. Sec is incorporated into selenoproteins via recoding of the stop codon UGA, with specific cis and trans factors…
View article: Effect of Statin Treatment on Obese Mice Lacking Selenocysteine Lyase
Effect of Statin Treatment on Obese Mice Lacking Selenocysteine Lyase Open
OBJECTIVES: Americans are a selenium-replete population with high use of statins, a drug commonly prescribed to ameliorate hypercholesterolemia. Statins act by inhibiting the first step of cholesterol biosynthesis in the liver, the mevalon…
View article: Selenium Regulates Hypothalamic Control of Energy Metabolism in a Sexually Dimorphic Manner
Selenium Regulates Hypothalamic Control of Energy Metabolism in a Sexually Dimorphic Manner Open
OBJECTIVES: The trace element selenium (Se) is known mainly for its antioxidant properties and is critical for proper brain function. The role of Se in regulating energy metabolism, and the sexually dimorphic nature of Se functions, howeve…
View article: Combined Omics Reveals That Disruption of the Selenocysteine Lyase Gene Affects Amino Acid Pathways in Mice
Combined Omics Reveals That Disruption of the Selenocysteine Lyase Gene Affects Amino Acid Pathways in Mice Open
Selenium is a nonmetal trace element that is critical for several redox reactions and utilized to produce the amino acid selenocysteine (Sec), which can be incorporated into selenoproteins. Selenocysteine lyase (SCL) is an enzyme which dec…
View article: Maternal cardiovascular-related single nucleotide polymorphisms, genes, and pathways associated with early-onset preeclampsia
Maternal cardiovascular-related single nucleotide polymorphisms, genes, and pathways associated with early-onset preeclampsia Open
Multiple cardiovascular genes and diseases demonstrate associations with early-onset preeclampsia. This unfolds new areas of research regarding the genetic determinants of early-onset preeclampsia and their relation to future cardiovascula…
View article: Agrp-Specific Ablation of Scly Protects against Diet-Induced Obesity and Leptin Resistance
Agrp-Specific Ablation of Scly Protects against Diet-Induced Obesity and Leptin Resistance Open
Selenium, an essential trace element known mainly for its antioxidant properties, is critical for proper brain function and regulation of energy metabolism. Whole-body knockout of the selenium recycling enzyme, selenocysteine lyase (Scly),…
View article: Disruption of Selenium Handling During Puberty Causes Sex-Specific Neurological Impairments in Mice
Disruption of Selenium Handling During Puberty Causes Sex-Specific Neurological Impairments in Mice Open
Selenium is an essential trace element linked to normal development and antioxidant defense mechanisms through its incorporation into selenoproteins via the amino acid, selenocysteine (Sec). Male mice lacking both the Se transporter, selen…
View article: SAT-564 The Role Of Se Recycling In Regulating Iodothyronine-deiodinases In The Skeletal Muscle
SAT-564 The Role Of Se Recycling In Regulating Iodothyronine-deiodinases In The Skeletal Muscle Open
T3 action is locally modulated by the intracellular type 2 (D2) and type 3 (D3) iodothyronine-deiodinases which convert the prohormone T4 to active T3, and inactivate T4 and T3, respectively. The synchronized expression of D3 followed by D…
View article: The Research Centers in Minority Institutions (RCMI) Translational Research Network: Building and Sustaining Capacity for Multi-Site Basic Biomedical, Clinical and Behavioral Research
The Research Centers in Minority Institutions (RCMI) Translational Research Network: Building and Sustaining Capacity for Multi-Site Basic Biomedical, Clinical and Behavioral Research Open
The Research Centers in Minority Institutions (RCMI) program was established by the US Congress to support the development of biomedical research infrastructure at minority-serving institutions granting doctoral degrees in the health pro…