Marleen Ansems
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View article: ATM and ATR inhibition increases radiosensitivity and cGAS-STING activation in prostate cancer
ATM and ATR inhibition increases radiosensitivity and cGAS-STING activation in prostate cancer Open
Despite the availability of multiple effective therapies for localized prostate cancer, many patients still progress to incurable metastasized castration resistant prostate cancer (mCRPC). About 23 % of mCRPC patients carry alterations in …
View article: Saponin-based adjuvant uptake and induction of antigen cross-presentation by CD11b+ dendritic cells and macrophages
Saponin-based adjuvant uptake and induction of antigen cross-presentation by CD11b+ dendritic cells and macrophages Open
View article: Cancer-associated fibroblasts, tumor and radiotherapy: interactions in the tumor micro-environment
Cancer-associated fibroblasts, tumor and radiotherapy: interactions in the tumor micro-environment Open
Cancer-associated fibroblasts (CAFs) represent a group of genotypically non-malignant stromal cells in the tumor micro-environment (TME) of solid tumors that encompasses up to 80% of the tumor volume. Even though the phenotypic diversity a…
View article: MHC-I and PD-L1 Expression is Associated with Decreased Tumor Outgrowth and is Radiotherapy-inducible in the Murine Head and Neck Squamous Cell Carcinoma Model MOC1
MHC-I and PD-L1 Expression is Associated with Decreased Tumor Outgrowth and is Radiotherapy-inducible in the Murine Head and Neck Squamous Cell Carcinoma Model MOC1 Open
Introduction Combined radiotherapy and immune checkpoint inhibition is a potential treatment option for head and neck squamous cell carcinoma (HNSCC). Immunocompetent mouse models can help to successfully develop radio- immunotherapy combi…
View article: NSAIDs affect dendritic cell cytokine production
NSAIDs affect dendritic cell cytokine production Open
Background Immunotherapy is now considered as the new pillar in treatment of cancer patients. Dendritic cells (DCs) play an essential role in stimulating anti-tumor immune responses, as they are capable of cross-presenting exogenous tumor …
View article: The immune microenvironment landscape shows treatment-specific differences in rectal cancer patients
The immune microenvironment landscape shows treatment-specific differences in rectal cancer patients Open
Neoadjuvant therapy is the cornerstone of modern rectal cancer treatment. Insights into the biology of tumor responses are essential for the successful implementation of organ-preserving strategies, as different treatments may lead to spec…
View article: Tissue-specific modifier alleles determine Mertk loss-of-function traits
Tissue-specific modifier alleles determine Mertk loss-of-function traits Open
Knockout (KO) mouse models play critical roles in elucidating biological processes behind disease-associated or disease-resistant traits. As a presumed consequence of gene KO, mice display certain phenotypes. Based on insight into the mole…
View article: Author response: Tissue-specific modifier alleles determine Mertk loss-of-function traits
Author response: Tissue-specific modifier alleles determine Mertk loss-of-function traits Open
View article: cGAS/cGAMP/STING signal propagation in the tumor microenvironment: Key role for myeloid cells in antitumor immunity
cGAS/cGAMP/STING signal propagation in the tumor microenvironment: Key role for myeloid cells in antitumor immunity Open
View article: Genotyping and Characterization of HPV Status, Hypoxia, and Radiosensitivity in 22 Head and Neck Cancer Cell Lines
Genotyping and Characterization of HPV Status, Hypoxia, and Radiosensitivity in 22 Head and Neck Cancer Cell Lines Open
To study head and neck squamous cell carcinomas (HNSCC) in vitro, a large variety of HNSCC cell lines have been developed. Here, we characterize a panel of 22 HNSCC cell lines, thereby providing a tool for research into tumor-specific trea…
View article: MR-Guided Radiotherapy: The Perfect Partner for Immunotherapy?
MR-Guided Radiotherapy: The Perfect Partner for Immunotherapy? Open
During the last years, preclinical and clinical studies have emerged supporting the rationale to integrate radiotherapy and immunotherapy. Radiotherapy may enhance the effects of immunotherapy by improving tumor antigen release, antigen pr…
View article: Polyisocyanide Hydrogels as a Tunable Platform for Mammary Gland Organoid Formation
Polyisocyanide Hydrogels as a Tunable Platform for Mammary Gland Organoid Formation Open
In the last decade, organoid technology has developed as a primary research tool in basic biological and clinical research. The reliance on poorly defined animal‐derived extracellular matrix, however, severely limits its application in reg…
View article: DC-SCRIPT affects mammary organoids branching morphogenesis by modulating the FGFR1-pERK signaling axis
DC-SCRIPT affects mammary organoids branching morphogenesis by modulating the FGFR1-pERK signaling axis Open
Loss of expression of the transcription regulator DC-SCRIPT (Zfp366) is a prominent prognostic event in estrogen receptor-positive breast cancer patients. Studying the inherent link between breast morphogenesis and tumorigenesis, we recent…
View article: Correction: C reactive protein impairs adaptive immunity in immune cells of patients with melanoma
Correction: C reactive protein impairs adaptive immunity in immune cells of patients with melanoma Open
View article: Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes
Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes Open
Background Tumor ablation techniques, like cryoablation, are successfully used in the clinic to treat tumors. The tumor debris remaining in situ after ablation is a major antigen depot, including neoantigens, which are presented by dendrit…
View article: AKT inhibition as a strategy for targeting hypoxic HPV-positive HNSCC
AKT inhibition as a strategy for targeting hypoxic HPV-positive HNSCC Open
These data suggest that HNSCC tumours are dependent on AKT to survive hypoxia, and that AKT inhibition is specifically effective in radioresistant hypoxic HPV-positive cells. Targeting AKT may thus be a potential way to overcome hypoxia in…
View article: The tumor microenvironment and radiotherapy response; a central role for cancer-associated fibroblasts
The tumor microenvironment and radiotherapy response; a central role for cancer-associated fibroblasts Open
View article: ACLY (ATP Citrate Lyase) Mediates Radioresistance in Head and Neck Squamous Cell Carcinomas and is a Novel Predictive Radiotherapy Biomarker
ACLY (ATP Citrate Lyase) Mediates Radioresistance in Head and Neck Squamous Cell Carcinomas and is a Novel Predictive Radiotherapy Biomarker Open
Radiotherapy is an important treatment modality of head and neck squamous cell carcinomas (HNSCC). Multiple links have been described between the metabolic activity of tumors and their clinical outcome. Here we test the hypothesis that met…
View article: Modular actin nano-architecture enables podosome protrusion and mechanosensing
Modular actin nano-architecture enables podosome protrusion and mechanosensing Open
Basement membrane transmigration during embryonal development, tissue homeostasis and tumor invasion relies on invadosomes, a collective term for invadopodia and podosomes. An adequate structural framework for this process is still missing…
View article: DC-SCRIPT deficiency delays mouse mammary gland development and branching morphogenesis
DC-SCRIPT deficiency delays mouse mammary gland development and branching morphogenesis Open
View article: Modular actin nano-architecture enables podosome protrusion and mechanosensing
Modular actin nano-architecture enables podosome protrusion and mechanosensing Open
Basement membrane transmigration during embryonal development, tissue homeostasis and tumor invasion relies on invadosomes, a collective term for invadopodia and podosomes. An adequate structural framework for this process is still missing…
View article: Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function
Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function Open
Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. Proper function of DCs is crucial to elicit an effective immune response against pathogens and to induce antitumor immunity. Different members of the…
View article: Microenvironmental derived factors modulating dendritic cell function and vaccine efficacy: the effect of prostanoid receptor and nuclear receptor ligands
Microenvironmental derived factors modulating dendritic cell function and vaccine efficacy: the effect of prostanoid receptor and nuclear receptor ligands Open
View article: Dendritic Cells Actively Limit Interleukin-10 Production Under Inflammatory Conditions via DC-SCRIPT and Dual-Specificity Phosphatase 4
Dendritic Cells Actively Limit Interleukin-10 Production Under Inflammatory Conditions via DC-SCRIPT and Dual-Specificity Phosphatase 4 Open
Dendritic cell (DC)-based immunotherapy makes use of the DC's ability to direct the adaptive immune response toward activation or inhibition. DCs perform this immune orchestration in part by secretion of selected cytokines. The most potent…
View article: DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells
DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells Open