Marlène Daloyau
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View article: A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects
A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects Open
Mitochondria continually move, fuse and divide and these dynamics are essential for the proper function of these organelles. Indeed, the dynamic balance of fusion and fission of mitochondria determines their morphology and allows their imm…
View article: OPA1 haploinsufficiency induces a BNIP3‐dependent decrease in mitophagy in neurons: relevance to Dominant Optic Atrophy
OPA1 haploinsufficiency induces a BNIP3‐dependent decrease in mitophagy in neurons: relevance to Dominant Optic Atrophy Open
Dominant optic atrophy (DOA) is because of mutations in the mitochondrial protein OPA1. The disease principally affects retinal ganglion cells, whose axons degenerate leading to vision impairments, and sometimes other neuronal phenotypes. …
View article: Loss of Msp1p in <i>Schizosaccharomyces pombe</i> induces a <scp>ROS</scp>‐dependent nuclear mutator phenotype that affects mitochondrial fission genes
Loss of Msp1p in <i>Schizosaccharomyces pombe</i> induces a <span>ROS</span>‐dependent nuclear mutator phenotype that affects mitochondrial fission genes Open
Mitochondria continually fuse and divide to dynamically adapt to changes in metabolism and stress. Mitochondrial dynamics are also required for mitochondrial DNA (mt DNA ) integrity; however, the underlying reason is not known. In this stu…
View article: Loss of functional <scp>OPA</scp> 1 unbalances redox state: implications in dominant optic atrophy pathogenesis
Loss of functional <span>OPA</span> 1 unbalances redox state: implications in dominant optic atrophy pathogenesis Open
Our study suggests that the pro-oxidative state induced by OPA1 loss may contribute to DOA pathogenesis and that differences in antioxidant defenses can explain the variability in expressivity. Furthermore, antioxidants may be used as ther…