Marlene Fischer
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View article: Impact of Emergence Delirium on Self-reported Postoperative Recovery After Noncardiac Surgery: A Prospective Cohort Study
Impact of Emergence Delirium on Self-reported Postoperative Recovery After Noncardiac Surgery: A Prospective Cohort Study Open
BACKGROUND: Patients’ perception of their health outcomes after surgery has become increasingly important in perioperative medicine. This study aimed to evaluate whether emergence delirium in the postanesthesia care unit (PACU) has a relev…
View article: Self-reported quality of recovery after radical prostatectomy—a prospective cohort study
Self-reported quality of recovery after radical prostatectomy—a prospective cohort study Open
Purpose The Quality of Recovery-15 questionnaire (QoR-15) has been developed to assess patient-reported recovery 24 h after non-cardiac surgery. This prospective cohort study sought to analyze patient-reported recovery throughout day five …
View article: Mozart for the brain - a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhage
Mozart for the brain - a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhage Open
Background: Classical music influences human physiology, such as the cerebral blood flow velocity (CBFV), in healthy controls and during recovery from ischemic stroke. Aim of this prospective pilot-study was to investigate the effect of cl…
View article: Cerebrovascular Autoregulation-Based Optimal Mean Arterial Pressure During Prostate Surgery – A Secondary Analysis of a Prospective Cohort Study
Cerebrovascular Autoregulation-Based Optimal Mean Arterial Pressure During Prostate Surgery – A Secondary Analysis of a Prospective Cohort Study Open
This study demonstrates a wide range of individual intraoperative MAPopt values and underscores that CVA-based MAPopt during non-cardiac surgery may differ from commonly accepted intraoperative MAP thresholds in clinical practice (ie 65 mm…
View article: Comparison of the Equivalence of <i>Aspergillus</i> Antigen and <scp>PCR</scp> Results Between Non‐Directed Bronchial Lavage and Bronchoalveolar Lavage—A Prospective Exploratory Pilot Study in Critically Ill Patients
Comparison of the Equivalence of <i>Aspergillus</i> Antigen and <span>PCR</span> Results Between Non‐Directed Bronchial Lavage and Bronchoalveolar Lavage—A Prospective Exploratory Pilot Study in Critically Ill Patients Open
Background Obtaining non‐directed samples from the upper bronchial tree is easier to perform and poses fewer risks for critically ill patients than deep bronchoalveolar lavage (BAL). Since invasive pulmonary aspergillosis is associated wit…
View article: Dose-dependent association of hyperoxia and decreased favorable outcomes in mechanically ventilated patients with traumatic brain injury, a retrospective cohort study
Dose-dependent association of hyperoxia and decreased favorable outcomes in mechanically ventilated patients with traumatic brain injury, a retrospective cohort study Open
View article: Mozart for the Brain - a Pilot Study on Physiological Effects of Auditive Stimulation in Patients after Aneurysmal Subarachnoid Hemorrhage
Mozart for the Brain - a Pilot Study on Physiological Effects of Auditive Stimulation in Patients after Aneurysmal Subarachnoid Hemorrhage Open
View article: Energy Expenditure in Critically Ill Patients with Aneurysmal Subarachnoid Hemorrhage, Intracerebral Hemorrhage, and Traumatic Brain Injury—A Prospective Observational Study
Energy Expenditure in Critically Ill Patients with Aneurysmal Subarachnoid Hemorrhage, Intracerebral Hemorrhage, and Traumatic Brain Injury—A Prospective Observational Study Open
Background: Energy expenditure (EE) in patients with aneurysmal subarachnoid hemorrhage (SAH) may differ from other intracranial pathologies, such as intracerebral hemorrhage (ICH) or traumatic brain injury (TBI), due to an activation of t…
View article: Fluid excess on intensive care unit after mechanical thrombectomy after acute ischemic stroke is associated with unfavorable neurological and functional outcomes: An observational cohort study
Fluid excess on intensive care unit after mechanical thrombectomy after acute ischemic stroke is associated with unfavorable neurological and functional outcomes: An observational cohort study Open
Introduction: Endovascular thrombectomy stands as a pivotal component in the standard care for patients experiencing acute ischemic stroke with large vessel occlusion. Subsequent care for patients often extends to a neurological intensive …
View article: Association of early changes in arterial carbon dioxide with acute brain injury in adult patients with extracorporeal membrane oxygenation: A ten-year retrospective study in a German tertiary care hospital
Association of early changes in arterial carbon dioxide with acute brain injury in adult patients with extracorporeal membrane oxygenation: A ten-year retrospective study in a German tertiary care hospital Open
Irrespective of the indication for ECMO, we did not find a significant association between the relative change in PaCO2 early after ECMO initiation and acute brain injury. Aside from early PaCO2 decline at cannulation…
View article: Personalised blood pressure management during major noncardiac surgery and postoperative neurocognitive disorders: a randomised trial
Personalised blood pressure management during major noncardiac surgery and postoperative neurocognitive disorders: a randomised trial Open
View article: Potential drug-drug interactions with nirmatrelvir/ritonavir in critically ill patients with COVID-19 – a retrospective observational study
Potential drug-drug interactions with nirmatrelvir/ritonavir in critically ill patients with COVID-19 – a retrospective observational study Open
Background Nirmatrelvir/ritonavir is recommended for high-risk patients with COVID-19 to reduce disease progression and mortality. Ritonavir significantly increases the bioavailability of nirmatrelvir and is the most potent irreversible cy…
View article: Early prediction of ventricular peritoneal shunt dependency in aneurysmal subarachnoid haemorrhage patients by recurrent neural network-based machine learning using routine intensive care unit data
Early prediction of ventricular peritoneal shunt dependency in aneurysmal subarachnoid haemorrhage patients by recurrent neural network-based machine learning using routine intensive care unit data Open
Aneurysmal subarachnoid haemorrhage (aSAH) can lead to complications such as acute hydrocephalic congestion. Treatment of this acute condition often includes establishing an external ventricular drainage (EVD). However, chronic hydrocephal…
View article: Psychometric evaluation of the modified quality of recovery score for the postanaesthesia care unit (QoR-PACU2)—A prospective validation study
Psychometric evaluation of the modified quality of recovery score for the postanaesthesia care unit (QoR-PACU2)—A prospective validation study Open
The QoR-PACU2 assesses self-reported QoR after surgery in the PACU. Measures of feasibility, validity, and reliability were consistently high. Measures of responsiveness were moderate, which might be attributable to the heteroge…
View article: Impact of Intraoperative Fluctuations of Cardiac Output on Cerebrovascular Autoregulation: An Integrative Secondary Analysis of Individual-level Data
Impact of Intraoperative Fluctuations of Cardiac Output on Cerebrovascular Autoregulation: An Integrative Secondary Analysis of Individual-level Data Open
Background: Intraoperative impairment of cerebral autoregulation (CA) has been associated with perioperative neurocognitive disorders. We investigated whether intraoperative fluctuations in cardiac index are associated with changes in CA. …
View article: Early acute kidney injury and transition to renal replacement therapy in critically ill patients with SARS-CoV-2 requiring veno-venous extracorporeal membrane oxygenation
Early acute kidney injury and transition to renal replacement therapy in critically ill patients with SARS-CoV-2 requiring veno-venous extracorporeal membrane oxygenation Open
View article: The impact of cognitive reserve on delayed neurocognitive recovery after major non-cardiac surgery: an exploratory substudy
The impact of cognitive reserve on delayed neurocognitive recovery after major non-cardiac surgery: an exploratory substudy Open
Introduction Delayed neurocognitive recovery is a common and severe complication after surgery and anesthesia with an adverse impact on daily living, morbidity, and mortality. High cognitive reserve may mitigate the development of delayed …
View article: Comparative analysis of characteristics and outcomes in hospitalized COVID-19 patients infected with different SARS-CoV-2 variants between January 2020 and April 2022 – A retrospective single-center cohort study
Comparative analysis of characteristics and outcomes in hospitalized COVID-19 patients infected with different SARS-CoV-2 variants between January 2020 and April 2022 – A retrospective single-center cohort study Open
In-hospital mortality and rate of ICU admission among hospitalized COVID-19 patients steadily decreased throughout the pandemic. However, the practically unchanged duration of hospitalization demonstrates the persistent burden of COVID-19 …
View article: Psychometric evaluation of a quality of recovery score for the postanesthesia care unit—A preliminary validation study
Psychometric evaluation of a quality of recovery score for the postanesthesia care unit—A preliminary validation study Open
Introduction Patients’ perception of postoperative recovery is a key aspect of perioperative care. Self-reported quality of recovery (QoR) has evolved as a relevant endpoint in perioperative research. Several psychometric instruments have …
View article: Impact of COVID-19 on Sedation Requirements during Veno-Venous Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome
Impact of COVID-19 on Sedation Requirements during Veno-Venous Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome Open
COVID-19-associated ARDS (C-ARDS) is mentioned to express higher analgosedation needs, in comparison to ARDS of other etiologies. The objective of this monocentric retrospective cohort study was to compare the analgosedation needs between …
View article: Clinical surrogates of dysautonomia predict lethal outcome in COVID-19 on intensive care unit
Clinical surrogates of dysautonomia predict lethal outcome in COVID-19 on intensive care unit Open
Background Unpredictable vegetative deteriorations made the treatment of patients with acute COVID-19 on intensive care unit particularly challenging during the first waves of the pandemic. Clinical correlates of dysautonomia and their imp…
View article: Oscillatory and aperiodic neuronal activity in working memory following anesthesia
Oscillatory and aperiodic neuronal activity in working memory following anesthesia Open
Aperiodic activity provides a potential electroencephalographic biomarker to identify patients at risk for postoperative cognitive impairments.
View article: Sotrovimab in Hospitalized Patients with SARS-CoV-2 Omicron Variant Infection: a Propensity Score-Matched Retrospective Cohort Study
Sotrovimab in Hospitalized Patients with SARS-CoV-2 Omicron Variant Infection: a Propensity Score-Matched Retrospective Cohort Study Open
This study shows that among hospitalized patients with SARS-CoV-2 Omicron variant infection at risk of disease progression, treatment with sotrovimab alone or in combination with remdesivir did not decrease in-hospital mortality. These rea…
View article: Outcomes of critically ill coronavirus disease 2019 patients requiring kidney replacement therapy: A retrospective cohort study
Outcomes of critically ill coronavirus disease 2019 patients requiring kidney replacement therapy: A retrospective cohort study Open
Background Coronavirus disease 2019 (COVID-19) has resulted in high hospitalization rates worldwide. Acute kidney injury (AKI) in patients hospitalized for COVID-19 is frequent and associated with disease severity and poor outcome. The aim…
View article: The impact of spinal anaesthesia on perioperative opioid consumption, postoperative pain and oncological outcome in radical retropubic prostatectomy—a retrospective before-and-after effectiveness study
The impact of spinal anaesthesia on perioperative opioid consumption, postoperative pain and oncological outcome in radical retropubic prostatectomy—a retrospective before-and-after effectiveness study Open
View article: Effect of Hemadsorption Therapy in Critically Ill Patients with COVID-19 (CYTOCOV-19): A Prospective Randomized Controlled Pilot Trial
Effect of Hemadsorption Therapy in Critically Ill Patients with COVID-19 (CYTOCOV-19): A Prospective Randomized Controlled Pilot Trial Open
Introduction: Immunomodulatory therapies have shown beneficial effects in patients with severe COVID-19. Patients with hypercytokinemia might benefit from the removal of inflammatory mediators via hemadsorption. Methods: Single-center pros…
View article: Left Ventricular Diastolic Dysfunction Is Not Associated With Pulmonary Edema in Septic Patients. A Prospective Observational Cohort Study
Left Ventricular Diastolic Dysfunction Is Not Associated With Pulmonary Edema in Septic Patients. A Prospective Observational Cohort Study Open
Purpose We aimed to investigate whether left ventricular diastolic dysfunction (LVDD) is associated with pulmonary edema in septic patients. Methods We conducted a prospective cohort study in adult septic patients between October 2018 and …
View article: Comparison of four diagnostic criteria for invasive pulmonary aspergillosis—A diagnostic accuracy study in critically ill patients
Comparison of four diagnostic criteria for invasive pulmonary aspergillosis—A diagnostic accuracy study in critically ill patients Open
Background In the absence of lung biopsy, there are various algorithms for the diagnosis of invasive pulmonary aspergillosis (IPA) in critically ill patients that rely on clinical signs, underlying conditions, radiological features and myc…
View article: Effect of sedative premedication with oral midazolam on postanesthesia care unit delirium in older adults: a secondary analysis following an uncontrolled before-after design
Effect of sedative premedication with oral midazolam on postanesthesia care unit delirium in older adults: a secondary analysis following an uncontrolled before-after design Open
View article: Changes of oscillatory and aperiodic neuronal activity in working memory following anaesthesia: a prospective observational study
Changes of oscillatory and aperiodic neuronal activity in working memory following anaesthesia: a prospective observational study Open
Background Anaesthesia and surgery can lead to cognitive decline, especially in the elderly. However, to date, the neurophysiological underpinnings of perioperative cognitive decline remain unknown. Methods We included male patients, who w…