Maroof Alam
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View article: Small molecule FICD inhibitors suppress endogenous and pathologic FICD-mediated protein AMPylation
Small molecule FICD inhibitors suppress endogenous and pathologic FICD-mediated protein AMPylation Open
Summary The AMP transferase, FICD, is an emerging drug target finetuning stress signaling in the endoplasmic reticulum (ER). FICD is a bi-functional enzyme, catalyzing both AMP addition (AMPylation) and removal (deAMPylation) from the ER r…
View article: Supplemental Figure S5AB from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC
Supplemental Figure S5AB from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC Open
Supplemental Figure S5AB. A. Lysates from H1299/CshRNA and H1299/MUC1shRNA cells were immunoblotted with the indicated antibodies. B. Representative images of tumorspheres derived from H1299/CshRNA and H1299/MUC1shRNA cells (left). Bar rep…
View article: Data from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC
Data from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC Open
The LIN28B→let-7 pathway contributes to regulation of the epithelial–mesenchymal transition (EMT) and stem cell self-renewal. The oncogenic MUC1-C transmembrane protein is aberrantly overexpressed in lung and other carcinomas; however, the…
View article: Supplemental Tables 1 and 2 from MUC1-C Represses the Crumbs Complex Polarity Factor CRB3 and Downregulates the Hippo Pathway
Supplemental Tables 1 and 2 from MUC1-C Represses the Crumbs Complex Polarity Factor CRB3 and Downregulates the Hippo Pathway Open
Supplemental Table S1. qRT-PCR Primer Pairs Supplemental Table S2. ChIP Primer Pairs
View article: Supplementary Figure S5ABC from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Supplementary Figure S5ABC from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells Open
Supplementary Figure S5ABC from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
View article: Supplemental Figure S2 from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC
Supplemental Figure S2 from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC Open
Supplemental Figure S2. MCF-7/MUC1-C cells were co-transfected with Lin28B-P1-Luc and SV-40-Renilla-Luc plasmids. At 48 h following transfection, cells were left untreated (Control), treated with DMSO as vehicle control, or treated with 5 …
View article: Supplemental Figure S1 from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC
Supplemental Figure S1 from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC Open
Supplemental Figure S1. Lysates from H1650 cells stably expressing a control scrambled shRNA (CshRNA) or a MUC1 shRNA were immunoblotted with the indicated antibodies.
View article: Supplemental Figure S4AB from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC
Supplemental Figure S4AB from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC Open
Supplemental Figure S4AB. A. H1299/CshRNA and H1299/MUC1shRNA cells were analyzed for let-7a-c miRNA levels by qRT-PCR. Results are expressed as relative let-7a-c levels (mean{plus minus}SD of three determinations) as compared to that obta…
View article: Supplemental Figure S1 from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC
Supplemental Figure S1 from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC Open
Supplemental Figure S1. Lysates from H1650 cells stably expressing a control scrambled shRNA (CshRNA) or a MUC1 shRNA were immunoblotted with the indicated antibodies.
View article: Supplemental Tables from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC
Supplemental Tables from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC Open
Supplemental Tables
View article: Supplementary Figures Legends 1-5, Table 1 from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Supplementary Figures Legends 1-5, Table 1 from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells Open
Supplementary Figures Legends 1-5, Table 1 from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
View article: Data from MUC1-C Represses the Crumbs Complex Polarity Factor CRB3 and Downregulates the Hippo Pathway
Data from MUC1-C Represses the Crumbs Complex Polarity Factor CRB3 and Downregulates the Hippo Pathway Open
Apical–basal polarity and epithelial integrity are maintained in part by the Crumbs (CRB) complex. The C-‐terminal subunit of MUC1 (MUC1-C) is a transmembrane protein that is expressed at the apical border of normal epithelial cells and ab…
View article: Supplemental Figure S3AB from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC
Supplemental Figure S3AB from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC Open
Supplemental Figure S3AB. A. Soluble chromatin from H1299 cells was precipitated with anti-NF-κB or a control IgG. The final DNA precipitates were amplified by qPCR with pairs of primers for the NF-κB binding region (NBR; +313 to +41…
View article: Supplementary Figure 1 from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Supplementary Figure 1 from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells Open
Supplementary Figure 1 from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
View article: Data from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC
Data from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC Open
The LIN28B→let-7 pathway contributes to regulation of the epithelial–mesenchymal transition (EMT) and stem cell self-renewal. The oncogenic MUC1-C transmembrane protein is aberrantly overexpressed in lung and other carcinomas; however, the…
View article: Supplemental Figure S4AB from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC
Supplemental Figure S4AB from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC Open
Supplemental Figure S4AB. A. H1299/CshRNA and H1299/MUC1shRNA cells were analyzed for let-7a-c miRNA levels by qRT-PCR. Results are expressed as relative let-7a-c levels (mean{plus minus}SD of three determinations) as compared to that obta…
View article: Data from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Data from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells Open
Non–small cell lung cancer (NSCLC) cells are often associated with constitutive activation of the phosphoinositide 3-kinase (PI3K) → Akt → mTOR pathway. The mucin 1 (MUC1) heterodimeric glycoprotein is aberrantly overexpressed in NSCLC cel…
View article: Supplementary Figure 1 from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Supplementary Figure 1 from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells Open
Supplementary Figure 1 from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
View article: Supplementary Figure S2ABCDE from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Supplementary Figure S2ABCDE from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells Open
Supplementary Figure S2ABCDE from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
View article: Supplemental Tables 1 and 2 from MUC1-C Represses the Crumbs Complex Polarity Factor CRB3 and Downregulates the Hippo Pathway
Supplemental Tables 1 and 2 from MUC1-C Represses the Crumbs Complex Polarity Factor CRB3 and Downregulates the Hippo Pathway Open
Supplemental Table S1. qRT-PCR Primer Pairs Supplemental Table S2. ChIP Primer Pairs
View article: Supplementary Figure S3AB from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Supplementary Figure S3AB from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells Open
Supplementary Figure S3AB from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
View article: Supplemental Figure S2 from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC
Supplemental Figure S2 from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC Open
Supplemental Figure S2. MCF-7/MUC1-C cells were co-transfected with Lin28B-P1-Luc and SV-40-Renilla-Luc plasmids. At 48 h following transfection, cells were left untreated (Control), treated with DMSO as vehicle control, or treated with 5 …
View article: Supplementary Figure S3AB from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Supplementary Figure S3AB from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells Open
Supplementary Figure S3AB from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
View article: Supplementary Figure S4ABC from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Supplementary Figure S4ABC from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells Open
Supplementary Figure S4ABC from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
View article: Supplementary Figures Legends 1-5, Table 1 from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Supplementary Figures Legends 1-5, Table 1 from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells Open
Supplementary Figures Legends 1-5, Table 1 from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
View article: Supplementary Figure S5ABC from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Supplementary Figure S5ABC from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells Open
Supplementary Figure S5ABC from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
View article: Supplementary Figure S4ABC from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Supplementary Figure S4ABC from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells Open
Supplementary Figure S4ABC from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
View article: Supplemental Figure 1 from MUC1-C Represses the Crumbs Complex Polarity Factor CRB3 and Downregulates the Hippo Pathway
Supplemental Figure 1 from MUC1-C Represses the Crumbs Complex Polarity Factor CRB3 and Downregulates the Hippo Pathway Open
MUC1-C regulates CRB3 expression.
View article: Data from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Data from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells Open
Non–small cell lung cancer (NSCLC) cells are often associated with constitutive activation of the phosphoinositide 3-kinase (PI3K) → Akt → mTOR pathway. The mucin 1 (MUC1) heterodimeric glycoprotein is aberrantly overexpressed in NSCLC cel…
View article: Supplementary Figure S2ABCDE from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Supplementary Figure S2ABCDE from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells Open
Supplementary Figure S2ABCDE from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells