Marry R. Smit
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View article: Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report
Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report Open
Background Almost all large-scale trials of disease-modifying therapeutic agents in critical care have failed to show benefit for patients, which may be explained in part by the clinical and biological heterogeneity inherent in virtually a…
View article: Targeted, Condensed Lung Ultrasound Training Program for Image Interpretation: A Prospective Multicenter Observational Study in Intensive Care Unit Professionals
Targeted, Condensed Lung Ultrasound Training Program for Image Interpretation: A Prospective Multicenter Observational Study in Intensive Care Unit Professionals Open
A short two hour training program may be sufficient for ICU healthcare professionals to achieve competency in lung ultrasound interpretation, even for subjects with no prior lung ultrasound experience. Further studies are needed to validat…
View article: Correlation of sonographic and radiographic scores of lung edema and metrics of shunt, dead space, and respiratory mechanics in invasively ventilated patients
Correlation of sonographic and radiographic scores of lung edema and metrics of shunt, dead space, and respiratory mechanics in invasively ventilated patients Open
The radiographic assessment of lung edema score and the global lung ultrasound score poorly correlate with shunt, dead space, and respiratory mechanics metrics in invasively ventilated patients. A counterintuitive moderation effect of acut…
View article: Quantitative CT-analysis of over aerated lung tissue and correlation with fibrosis extent in patients with idiopathic pulmonary fibrosis
Quantitative CT-analysis of over aerated lung tissue and correlation with fibrosis extent in patients with idiopathic pulmonary fibrosis Open
This study provides the first evidence of radiological signs of lung over aeration in patients with UIP-pattern patients when passing from RV to TLC. These findings offer new insights into the complex interplay between mechanical forces, l…
View article: Lung ultrasound and ARDS: global collaboration is the way to go
Lung ultrasound and ARDS: global collaboration is the way to go Open
View article: Pulmonary herpes simplex virus and cytomegalovirus in patients with acute respiratory distress syndrome related to COVID-19
Pulmonary herpes simplex virus and cytomegalovirus in patients with acute respiratory distress syndrome related to COVID-19 Open
In mechanically ventilated COVID-19 patients, HSV reactivations are common, while CMV reactivations were rare. HSV viral load dynamics prior to or without antiviral treatment are associated with mortality. Alveolar inflammation is elevated…
View article: Associations of early changes in lung ultrasound aeration scores and mortality in invasively ventilated patients: a post hoc analysis
Associations of early changes in lung ultrasound aeration scores and mortality in invasively ventilated patients: a post hoc analysis Open
Background Lung ultrasound (LUS) in an emerging technique used in the intensive care unit (ICU). The derivative LUS aeration score has been shown to have associations with mortality in invasively ventilated patients. This study assessed th…
View article: Diagnostic accuracy of lung ultrasound in diagnosis of ARDS and identification of focal or non-focal ARDS subphenotypes: a systematic review and meta-analysis
Diagnostic accuracy of lung ultrasound in diagnosis of ARDS and identification of focal or non-focal ARDS subphenotypes: a systematic review and meta-analysis Open
Background Acute respiratory distress syndrome (ARDS) is a life-threatening respiratory condition with high mortality rates, accounting for 10% of all intensive care unit admissions. Lung ultrasound (LUS) as diagnostic tool for acute respi…
View article: Stress–strain curve and elastic behavior of the fibrotic lung with usual interstitial pneumonia pattern during protective mechanical ventilation
Stress–strain curve and elastic behavior of the fibrotic lung with usual interstitial pneumonia pattern during protective mechanical ventilation Open
View article: Personalized mechanical ventilation guided by ultrasound in patients with acute respiratory distress syndrome (PEGASUS): study protocol for an international randomized clinical trial
Personalized mechanical ventilation guided by ultrasound in patients with acute respiratory distress syndrome (PEGASUS): study protocol for an international randomized clinical trial Open
View article: From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU
From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU Open
Critical care uses syndromic definitions to describe patient groups for clinical practice and research. There is growing recognition that a "precision medicine" approach is required and that integrated biologic and physiologic data identif…
View article: Lung ultrasound for diagnosis and management of ARDS
Lung ultrasound for diagnosis and management of ARDS Open
View article: The effect of immunosuppressive therapies on the endothelial host response in critically ill COVID-19 patients
The effect of immunosuppressive therapies on the endothelial host response in critically ill COVID-19 patients Open
While several effective therapies for critically ill patients with COVID-19 have been identified in large, well-conducted trials, the mechanisms underlying these therapies have not been investigated in depth. Our aim is to investigate the …
View article: Breath metabolomics for diagnosis of acute respiratory distress syndrome
Breath metabolomics for diagnosis of acute respiratory distress syndrome Open
View article: Quantitative CT-analysis of over aerated lung tissue and correlation with fibrosis extent in patients with idiopathic pulmonary fibrosis
Quantitative CT-analysis of over aerated lung tissue and correlation with fibrosis extent in patients with idiopathic pulmonary fibrosis Open
INTRODUCTION The usual interstitial pneumonia (UIP) pattern, hallmark of idiopathic pulmonary fibrosis (IPF), may induce harmful local overdistension during mechanical ventilation given the juxtaposition of different tissue elasticities. M…
View article: Biomarker Analysis Provides Evidence for Host Response Homogeneity in Patients With COVID-19
Biomarker Analysis Provides Evidence for Host Response Homogeneity in Patients With COVID-19 Open
View article: Personalized Mechanical Ventilation Guided by UltraSound in Patients with Acute Respiratory Distress Syndrome (PEGASUS): study protocol for an international randomized clinical trial.
Personalized Mechanical Ventilation Guided by UltraSound in Patients with Acute Respiratory Distress Syndrome (PEGASUS): study protocol for an international randomized clinical trial. Open
Background: Acute respiratory distress syndrome (ARDS) is a frequent cause of hypoxemic respiratory failure with a mortality rate of approximately 30%. Identifying ARDS subphenotypes based on “focal” or “non-focal” lung morphology has the …
View article: Correlation between Serum Biomarkers and Lung Ultrasound in COVID-19: An Observational Study
Correlation between Serum Biomarkers and Lung Ultrasound in COVID-19: An Observational Study Open
Serum biomarkers and lung ultrasound are important measures for prognostication and treatment allocation in patients with COVID-19. Currently, there is a paucity of studies investigating relationships between serum biomarkers and ultrasono…
View article: HS-GC–MS analysis of volatile organic compounds after hyperoxia-induced oxidative stress: a validation study
HS-GC–MS analysis of volatile organic compounds after hyperoxia-induced oxidative stress: a validation study Open
Background Exhaled volatile organic compounds (VOCs), particularly hydrocarbons from oxidative stress-induced lipid peroxidation, are associated with hyperoxia exposure. However, important heterogeneity amongst identified VOCs and concerns…
View article: Stress-strain curve and elastic behavior of the fibrotic lung with usual interstitial pneumonia pattern during protective mechanical ventilation
Stress-strain curve and elastic behavior of the fibrotic lung with usual interstitial pneumonia pattern during protective mechanical ventilation Open
Background Patients with acute exacerbation of lung fibrosis with usual interstitial pneumonia (AE-ILD-UIP) pattern are at increased risk for ventilator-induced lung injury (VILI) and mortality when exposed to mechanical ventilation (MV). …
View article: Host Response Changes and Their Association with Mortality in COVID-19 Patients with Lymphopenia
Host Response Changes and Their Association with Mortality in COVID-19 Patients with Lymphopenia Open
Rationale: Lymphopenia in coronavirus disease (COVID-19) is associated with increased mortality. Objectives: To explore the association between lymphopenia, host response aberrations, and mortality in patients with lymphopeni…
View article: The diagnostic accuracy of lung ultrasound to determine PiCCO-derived extravascular lung water in invasively ventilated patients with COVID-19 ARDS
The diagnostic accuracy of lung ultrasound to determine PiCCO-derived extravascular lung water in invasively ventilated patients with COVID-19 ARDS Open
Background Lung ultrasound (LUS) can detect pulmonary edema and it is under consideration to be added to updated acute respiratory distress syndrome (ARDS) criteria. However, it remains uncertain whether different LUS scores can be used to…
View article: Platelets of COVID-19 patients display mitochondrial dysfunction, oxidative stress, and energy metabolism failure compatible with cell death
Platelets of COVID-19 patients display mitochondrial dysfunction, oxidative stress, and energy metabolism failure compatible with cell death Open
View article: The Global Definition of Acute Respiratory Distress Syndrome: Ready for Prime Time?
The Global Definition of Acute Respiratory Distress Syndrome: Ready for Prime Time? Open
View article: Octane in exhaled breath to diagnose acute respiratory distress syndrome in invasively ventilated intensive care unit patients
Octane in exhaled breath to diagnose acute respiratory distress syndrome in invasively ventilated intensive care unit patients Open
Background The concentration of exhaled octane has been postulated as a reliable biomarker for acute respiratory distress syndrome (ARDS) using metabolomics analysis with gas chromatography and mass spectrometry (GC-MS). A point-of-care (P…
View article: Validation of New Quantitative Lung Ultrasound Protocol and Comparison With Lung Ultrasound Score in Patients With COVID-19
Validation of New Quantitative Lung Ultrasound Protocol and Comparison With Lung Ultrasound Score in Patients With COVID-19 Open
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View article: Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection
Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection Open
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View article: Endothelial Permeability and the Angiopoietin/Tie2 System Following Mild and Severe COVID-19
Endothelial Permeability and the Angiopoietin/Tie2 System Following Mild and Severe COVID-19 Open
Endotheliopathy plays a role in the development of acute kidney and lung injury in COVID-19, probably due to inflammation, endothelial permeability, vascular leakage and edema formation. This study examined alterations in the circulation o…
View article: Reply to Volpicelli and Bouhemad
Reply to Volpicelli and Bouhemad Open
"Reply to: Quantify or Diagnose ARDS by Lung Ultrasound." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Age-related changes in plasma biomarkers and their association with mortality in COVID-19
Age-related changes in plasma biomarkers and their association with mortality in COVID-19 Open
Background Coronavirus disease 2019 (COVID-19)-induced mortality occurs predominantly in older patients. Several immunomodulating therapies seem less beneficial in these patients. The biological substrate behind these observations is unkno…