Marshal D. Wolff
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View article: Electrographic seizures and brain hyperoxia may be key etiological factors for postconcussive deficits
Electrographic seizures and brain hyperoxia may be key etiological factors for postconcussive deficits Open
We monitor oxygenation and electrographic activity in the hippocampus, immediately before and after mild traumatic brain injury. We demonstrate that as the number of injuries increases from 1 to 3, the proportion of rats that exhibit elect…
View article: Dynamic Oxygen Changes with Status Epilepticus, Seizures, and the Postictal State
Dynamic Oxygen Changes with Status Epilepticus, Seizures, and the Postictal State Open
The adult human brain consumes a highly disproportionate amount of oxygen and glucose relative to its size. Maintenance of the partial pressure of oxygen (pO2) within the normoxic range is critical for brain health; too little oxygen leads…
View article: Dynamic oxygen changes during status epilepticus and subsequent endogenous kindling
Dynamic oxygen changes during status epilepticus and subsequent endogenous kindling Open
Objective Brain tissue oxygen (partial oxygen pressure [pO 2 ]) levels are tightly regulated to stay within the normoxic zone, with deviations on either side resulting in impaired brain function. Whereas pathological events such as ischemi…
View article: Postictal behavioural impairments are due to a severe prolonged hypoperfusion/hypoxia event that is COX-2 dependent
Postictal behavioural impairments are due to a severe prolonged hypoperfusion/hypoxia event that is COX-2 dependent Open
Seizures are often followed by sensory, cognitive or motor impairments during the postictal phase that show striking similarity to transient hypoxic/ischemic attacks. Here we show that seizures result in a severe hypoxic attack confined to…
View article: Author response: Postictal behavioural impairments are due to a severe prolonged hypoperfusion/hypoxia event that is COX-2 dependent
Author response: Postictal behavioural impairments are due to a severe prolonged hypoperfusion/hypoxia event that is COX-2 dependent Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Seizures are often followed by sensory, cogniti…