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Fractionation of Lignin with Aqueous Organic Solvents: A Step Closer to Sustainable Wood Biorefinery Open
Recent rapid developments in forest biomass valorisation have highlighted lignin as a key value driver for the economic sustainability of modern biorefining. Sugar-based biorefinery hydrolysis lignin (HL) from wood biomass has an immense p…
Fractionation of Lignin with Aqueous Organic Solvents: A Step Closer to Sustainable Wood Biorefinery Open
Recent rapid developments in forest biomass valorisation have highlighted lignin as a key value driver for the economic sustainability of modern biorefining. Sugar-based biorefinery hydrolysis lignin (HL) from wood biomass has an immense p…
Ultrasound effect on a biorefinery lignin-cellulose mixture Open
Forest biorefineries provide multiple new avenues for applied research. The main concept lies in the malleability of the processes and their stepwise organization. The core element of the biorefinery concept addressed in the present study …
Translational control of <i>MPS1</i> links protein synthesis with the initiation of cell division and spindle pole body duplication in <i>Saccharomyces cerevisiae</i> Open
Protein synthesis underpins cell growth and controls when cells commit to a new round of cell division at a point in late G1 of the cell cycle called Start. Passage through Start also coincides with the duplication of the microtubule-organ…
Bioconversion of Glucose-Rich Lignocellulosic Wood Hydrolysates to 3-Hydroxypropionic Acid and Succinic Acid using Engineered <i>Saccharomyces cerevisiae</i> Open
Background 3-hydroxypropionic acid (3-HP) and succinic acid (SA) were announced as two of the top twelve value-added platform chemicals from biomass out of a group of over 300 potential compounds that could be made from biomass in a govern…
CDK signaling via nonconventional CDK phosphorylation sites Open
Since the discovery of cyclin-dependent kinases (CDKs), it has been perceived as a dogma that CDK signaling in the cell cycle is mediated via targeting the CDK consensus sites: the optimal and the minimal motifs S/T-P-x-K/R and S/T-P, resp…
View article: Conversion of aromatic compounds from fractionated industrial hydrolysis lignin by <i>Pseudomonas putida</i> and environmental microbial strains
Conversion of aromatic compounds from fractionated industrial hydrolysis lignin by <i>Pseudomonas putida</i> and environmental microbial strains Open
Background The utilization of Pseudomonas putida was explored in this study as a promising approach for lignin valorization. To this end, dry hydrolysis lignin was used as a feedstock for the first time. Hydrolysis lignin is a product of t…
Enzymatic Conversion of Hydrolysis Lignin—A Potential Biorefinery Approach Open
Lignin is an abundant and renewable source capable of replacing different raw materials in the chemical industry. It can be obtained from lignocellulosic biomass (LCB) via different pretreatment methods. In the present study, hydrolysis li…
A synthetic biology approach reveals diverse and dynamic CDK response profiles via multisite phosphorylation of NLS-NES modules Open
The complexity of multisite phosphorylation mechanisms in regulating nuclear localization signals (NLSs) and nuclear export signals (NESs) is not understood, and its potential has not been used in synthetic biology. The nucleocytoplasmic s…
Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae. Open
Cdc6, a subunit of the pre-replicative complex (pre-RC), contains multiple regulatory cyclin-dependent kinase (Cdk1) consensus sites, SP or TP motifs. In Saccharomyces cerevisiae, Cdk1 phosphorylates Cdc6-T7 to recruit Cks1, the Cdk1 phosp…
Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14 and Sic1 for origin licensing in <i>S. cerevisiae</i> Open
Cdc6, a subunit of the pre-replicative complex, contains multiple regulatory Cdk1 consensus sites, SP or TP motifs. In S. cerevisiae , Cdk1 phosphorylates Cdc6-T7 to recruit Cks1, the Cdk1 phospho-adaptor in S-phase, for subsequent multisi…
Docking to a Basic Helix Promotes Specific Phosphorylation by G1-Cdk1 Open
Cyclins are the activators of cyclin-dependent kinase (CDK) complex, but they also act as docking scaffolds for different short linear motifs (SLiMs) in CDK substrates and inhibitors. According to the unified model of CDK function, the cel…
Cdc4 phospho-degrons allow differential regulation of Ame1CENP-U protein stability across the cell cycle Open
Kinetochores are multi-subunit protein assemblies that link chromosomes to microtubules of the mitotic and meiotic spindle. It is still poorly understood how efficient, centromere-dependent kinetochore assembly is accomplished from hundred…
Differentially accessible Cdc4 phospho-degrons regulate Ctf19 <sup>CCAN</sup> kinetochore subunit stability in mitosis Open
Kinetochores are multi-subunit protein assemblies that link chromosomes to microtubules of the mitotic and meiotic spindle. How effective, yet strictly centromere-dependent kinetochore assembly is coupled to cell cycle progression is incom…
View article: Multisite phosphorylation by Cdk1 initiates delayed negative feedback to control mitotic transcription
Multisite phosphorylation by Cdk1 initiates delayed negative feedback to control mitotic transcription Open
Summary Cell-cycle progression is driven by the phosphorylation of cyclin-dependent kinase (Cdk) substrates 1–3 . The order of substrate phosphorylation depends in part on the general rise in Cdk activity during the cell cycle 4–7 , togeth…
View article: The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV
The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV Open
The Spike protein of the novel coronavirus SARS-CoV2 contains an insertion 680 S PRRA R↓SV 687 forming a cleavage motif RxxR for furin-like enzymes at the boundary of S1/S2 subunits. Cleavage at S1/S2 is important for efficient viral entry…
Regulation of trehalase activity by multi-site phosphorylation and 14-3-3 interaction Open
Protein phosphorylation enables a rapid adjustment of cellular activities to diverse intracellular and environmental stimuli. Many phosphoproteins are targeted on more than one site, which allows the integration of multiple signals and the…
Biochemical evidence of furin specificity and potential for phospho-regulation at Spike protein S1/S2 cleavage site in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV Open
The Spike protein of the novel coronavirus SARS-CoV2 contains an insertion 680 S PRRA R↓SV 687 forming a cleavage motif RxxR for furin-like enzymes at the boundary of S1/S2 subunits. Cleavage at S1/S2 is important for efficient viral entry…