Marta Bosia
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View article: A rapid assessment of pragmatic abilities and cognitive substrates: The German APACS Brief
A rapid assessment of pragmatic abilities and cognitive substrates: The German APACS Brief Open
BackgroundClinical evaluation of language abilities is central to diagnosing impairments in neurological and neuropsychiatric conditions, such as brain injuries, Parkinson’s disease, or schizophrenia. However, assessment tools predominantl…
View article: Microdosing Psychedelics to Restore Synaptic Density in Schizophrenia
Microdosing Psychedelics to Restore Synaptic Density in Schizophrenia Open
Schizophrenia is a highly polygenic disease, and several genetic variants associated with the disease converge on altered synaptic homeostasis. In particular, the gene encoding complement component 4 (C4) showed the strongest association w…
View article: Ten years of using the APACS test: a multistudy cross-diagnostic analysis of pragmatic profiles and their relationship with Theory of Mind
Ten years of using the APACS test: a multistudy cross-diagnostic analysis of pragmatic profiles and their relationship with Theory of Mind Open
Pragmatic impairments are largely documented, yet rarely considered in clinical practice, also due to a poor characterization of pragmatic profiles across conditions, as well as some overlap with theory of mind (ToM) in the conceptualizati…
View article: Two is Better Than One: Potentiating Cognitive Remediation With Aerobic Exercise to Improve Cognition in Schizophrenia With a Randomized Controlled Trial
Two is Better Than One: Potentiating Cognitive Remediation With Aerobic Exercise to Improve Cognition in Schizophrenia With a Randomized Controlled Trial Open
Background: Cognitive impairment is a core feature of schizophrenia, for which pharmacological interventions have limited efficacy. Cognitive remediation (CR) is the gold standard for addressing cognitive deficits, yet its effect remains i…
View article: Ten years of using the APACS test: a multistudy cross-diagnostic analysis of pragmatic profiles and their relationship with Theory of Mind
Ten years of using the APACS test: a multistudy cross-diagnostic analysis of pragmatic profiles and their relationship with Theory of Mind Open
Pragmatic impairments are largely documented, yet rarely considered in clinical practice, also due to a poor characterization of pragmatic profiles across conditions, as well as some overlap with theory of mind (ToM) in the conceptualizati…
View article: Moving toward precision and personalized treatment strategies in psychiatry
Moving toward precision and personalized treatment strategies in psychiatry Open
Precision psychiatry aims to improve routine clinical practice by integrating biological, clinical, and environmental data. Many studies have been performed in different areas of research on major depressive disorder, bipolar disorder, and…
View article: Toward precision psychiatry: multimodal machine learning combining neurophysiological and language features to predict symptoms severity in schizophrenia
Toward precision psychiatry: multimodal machine learning combining neurophysiological and language features to predict symptoms severity in schizophrenia Open
Introduction Capturing the complex and heterogeneous clinical phenotypes across Schizophrenia Spectrum Disorders (SSD) is still challenging and Artificial Intelligence is a promising tool. In the past years, machine learning (ML) models ha…
View article: Disentangling the contribution of inflammatory markers and kynurenines to cognitive impairment in schizophrenia
Disentangling the contribution of inflammatory markers and kynurenines to cognitive impairment in schizophrenia Open
Introduction Neuroinflammation and the Kynurenine Pathway (KP) have gained attention in the last decades in the pathogenesis of cognitive impairment in schizophrenia. Pro-inflammatory cytokines and microglia activation induce oxidative str…
View article: Disentangling clinical heterogeneity in schizophrenia through neuropsychophysiological profiles
Disentangling clinical heterogeneity in schizophrenia through neuropsychophysiological profiles Open
Introduction Cognitive disruption is a key feature in schizophrenia, and the identification of the neurophysiological underpinnings is of particular interest. One of the most promising markers of cognition is aperiodic activity, which is c…
View article: Metabolic Syndrome and Schizophrenia: Adding a Piece to the Interplay Between the Kynurenine Pathway and Inflammation
Metabolic Syndrome and Schizophrenia: Adding a Piece to the Interplay Between the Kynurenine Pathway and Inflammation Open
The biology of schizophrenia is highly complex and multifaceted. Numerous efforts have been made over the years to disentangle the heterogeneity of the disease, gradually leading to a more detailed understanding of its underlying pathogeni…
View article: Determinants of patient satisfaction in clozapine users: results from the Clozapine International Consortium (CLOZIN)
Determinants of patient satisfaction in clozapine users: results from the Clozapine International Consortium (CLOZIN) Open
View article: From semantic concreteness to concretism in schizophrenia: An automated linguistic analysis of speech produced in figurative language interpretation
From semantic concreteness to concretism in schizophrenia: An automated linguistic analysis of speech produced in figurative language interpretation Open
Lack of abstract thinking, known as concretism, is a well-known psychopathological feature of schizophrenia, reflecting the tendency to adhere to concrete aspects of stimuli and figurative language comprehension difficulties. Inspir…
View article: Navigating the Complexity of Psychotic Disorders: A Systematic Review of EEG Microstates and Machine Learning
Navigating the Complexity of Psychotic Disorders: A Systematic Review of EEG Microstates and Machine Learning Open
EEG microstates are brief, stable topographical configurations of brain activity that provide insights into alterations in brain function and connectivity. Anomalies in microstates are associated with different neuropsychiatric conditions,…
View article: DECODING THE LINK AMONG SCHIZOPHRENIA, METABOLIC SYNDROME, AND THE SEROTONIN/MELATONIN PATHWAY USING THE MK-801 MOUSE MODEL
DECODING THE LINK AMONG SCHIZOPHRENIA, METABOLIC SYNDROME, AND THE SEROTONIN/MELATONIN PATHWAY USING THE MK-801 MOUSE MODEL Open
Background Schizophrenia, a complex and debilitating psychiatric disorder, is often comorbid with metabolic syndrome, intertwining the realms of mental health and physiological dysregulation. Serotonin (5-HT), a neurotransmitter derived fr…
View article: Development and Validation of a Rapid Tool to Measure Pragmatic Abilities: The Brief Assessment of Pragmatic Abilities and Cognitive Substrates (APACS Brief)
Development and Validation of a Rapid Tool to Measure Pragmatic Abilities: The Brief Assessment of Pragmatic Abilities and Cognitive Substrates (APACS Brief) Open
Pragmatics is key to communicating effectively, and its assessment in vulnerable populations is of paramount importance. Although tools exist for this purpose, they are often effortful and time-consuming, with complex scoring procedures, w…
View article: Characterizing the patient experience of physical restraint in psychiatric settings via a linguistic, sentiment, and metaphor analysis
Characterizing the patient experience of physical restraint in psychiatric settings via a linguistic, sentiment, and metaphor analysis Open
View article: The clock is ticking on schizophrenia: a study protocol for a translational study integrating phenotypic, genomic, microbiome and biomolecular data to overcome disability
The clock is ticking on schizophrenia: a study protocol for a translational study integrating phenotypic, genomic, microbiome and biomolecular data to overcome disability Open
Background Shared biological factors may play a role in both the cognitive deficits and the increased prevalence of metabolic syndrome observed in individuals with Schizophrenia (SCZ). These factors could entail disturbances in tryptophan …
View article: Ten years of using the APACS test: a multistudy cross-diagnostic analysis of pragmatic profiles and their relationship with Theory of Mind
Ten years of using the APACS test: a multistudy cross-diagnostic analysis of pragmatic profiles and their relationship with Theory of Mind Open
Pragmatic impairments are largely documented, yet rarely considered in clinical practice, also due to a poor characterization of pragmatic profiles across conditions, as well as some overlap with theory of mind (ToM) in the conceptualizati…
View article: Neuroinflammation and kynurenines in schizophrenia: Impact on cognition depending on cognitive functioning and modulatory properties in relation to cognitive remediation and aerobic exercise
Neuroinflammation and kynurenines in schizophrenia: Impact on cognition depending on cognitive functioning and modulatory properties in relation to cognitive remediation and aerobic exercise Open
Overall, these findings add novel evidence on the biological underpinnings of cognitive impairment in schizophrenia pointing at a differential role of neuroinflammation and KP metabolites in inducing cognitive deficits depending on the cog…
View article: From semantic concreteness to concretism in schizophrenia: An automated linguistic analysis of speech produced in figurative language interpretation
From semantic concreteness to concretism in schizophrenia: An automated linguistic analysis of speech produced in figurative language interpretation Open
Lack of abstract thinking, known as concretism, is a well-known psychopathological feature of schizophrenia, reflecting the tendency to adhere to concrete aspects of stimuli and figurative language comprehension difficulties. Inspired by t…
View article: Physical restraint in psychiatric settings: A novel characterization of the patient's experience via a linguistic, sentiment, and metaphor analysis
Physical restraint in psychiatric settings: A novel characterization of the patient's experience via a linguistic, sentiment, and metaphor analysis Open
Physical Restraint (PR) is a coercive procedure used in emergency psychiatric care to ensure safety in life-threatening situations. Because of its traumatic nature, studies emphasize the importance of considering the patient's subjective e…
View article: Physical restraint in psychiatric settings: A novel characterization of the patient's experience via a linguistic, sentiment, and metaphor analysis
Physical restraint in psychiatric settings: A novel characterization of the patient's experience via a linguistic, sentiment, and metaphor analysis Open
Physical Restraint (PR) is a coercive procedure used in emergency psychiatric care to ensure safety in life-threatening situations. Because of its traumatic nature, studies emphasize the importance of considering the patient's subjective e…
View article: Pragmatic language disorder in schizophrenia: assessment through a novel brief tool
Pragmatic language disorder in schizophrenia: assessment through a novel brief tool Open
View article: Neuroinflammation and Kynurenines in schizophrenia: impact on cognition and modulatory properties after cognitive remediation and aerobic exercise
Neuroinflammation and Kynurenines in schizophrenia: impact on cognition and modulatory properties after cognitive remediation and aerobic exercise Open
View article: Focusing on clozapine outcome: untying the knots of sex and pharmacokinetics
Focusing on clozapine outcome: untying the knots of sex and pharmacokinetics Open
View article: From gut to brain: insights on schizophrenia from a murine model
From gut to brain: insights on schizophrenia from a murine model Open
View article: Adverse childhood experiences in schizophrenia: the impact on cognitive outcome and metabolic dysregulation
Adverse childhood experiences in schizophrenia: the impact on cognitive outcome and metabolic dysregulation Open
View article: Cognitive remediation combined with aerobic exercise to further improve cognition in schizophrenia
Cognitive remediation combined with aerobic exercise to further improve cognition in schizophrenia Open
View article: Sleep quality in schizophrenia: association with psychopathology, cognition and metabolic syndrome
Sleep quality in schizophrenia: association with psychopathology, cognition and metabolic syndrome Open
View article: Schizophrenia, metabolic syndrome and the melatonin system: unraveling the dopamine-serotonin connection in the MK-801 mouse model
Schizophrenia, metabolic syndrome and the melatonin system: unraveling the dopamine-serotonin connection in the MK-801 mouse model Open