Marta Di Forti
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View article: T77. POLYGENIC AND ENVIRONMENTAL PREDICTORS OF CLINICAL AND FUNCTIONAL OUTCOMES FOLLOWING FIRST-EPISODE PSYCHOSIS
T77. POLYGENIC AND ENVIRONMENTAL PREDICTORS OF CLINICAL AND FUNCTIONAL OUTCOMES FOLLOWING FIRST-EPISODE PSYCHOSIS Open
View article: The effect of prenatal psychotropic drug exposures on obstetric complications: 19-year population-based study
The effect of prenatal psychotropic drug exposures on obstetric complications: 19-year population-based study Open
Background Although current prescribing guidelines suggest continuation of psychotropic drugs in pregnant women, population-based evidence supporting their safety is limited. Aims This study aims to clarify the plausible causal links betwe…
View article: The rising tide of drug-induced psychosis
The rising tide of drug-induced psychosis Open
Summary Recreational use of psychotogenic drugs has become more common in the last 30 years with consequent increase in drug-induced psychosis; 25–50% of such psychoses progress to schizophrenia within 5 years. Most cases result from abuse…
View article: Are reasons for first using cannabis associated with subsequent cannabis consumption (standard THC units) and psychopathology?
Are reasons for first using cannabis associated with subsequent cannabis consumption (standard THC units) and psychopathology? Open
Background Reasons for first using cannabis (RFUC) may influence later use patterns and mental health outcomes. However, limited research has explored self-medication versus social RFUCs in depth, and their associations with cannabis use p…
View article: Interplay Between Childhood Maltreatment, Subclinical Post‐Traumatic Stress Symptoms, and <scp>IQ</scp>: Findings From the <scp>EU</scp>‐<scp>GEI</scp> Multicentre Case–Control Study
Interplay Between Childhood Maltreatment, Subclinical Post‐Traumatic Stress Symptoms, and <span>IQ</span>: Findings From the <span>EU</span>‐<span>GEI</span> Multicentre Case–Control Study Open
Introduction Evidence suggests that childhood maltreatment affects cognitive performance in both patients with psychosis and community controls. However, the interplay between childhood maltreatment, post‐traumatic stress symptoms (PTSS), …
View article: Jumping to Conclusions and Facial Emotion Recognition in First-Episode Psychosis: Longitudinal Insights from the Gap Follow-Up Study.
Jumping to Conclusions and Facial Emotion Recognition in First-Episode Psychosis: Longitudinal Insights from the Gap Follow-Up Study. Open
These findings demonstrate that JTC and FER are stable in people with psychosis and controls. Therefore, they may serve as important treatment targets for early intervention in psychosis. Future research should integrate the potential role…
View article: Cannabis Withdrawal and Psychiatric Intensive Care
Cannabis Withdrawal and Psychiatric Intensive Care Open
Importance Cannabis use is common in people with severe mental illness and its adverse effects on outcomes are well established. However, adverse outcomes may also result from cannabis withdrawal syndrome (CWS). CWS includes symptoms such …
View article: Multi-ancestry genetic architecture of sleep duration and its relationship to other sleep and psychiatric phenotypes
Multi-ancestry genetic architecture of sleep duration and its relationship to other sleep and psychiatric phenotypes Open
Differences in sleep duration, quality, and timing are associated with variation in cognition, health outcomes, and quality of life. Genetic studies may help explain the underlying mechanisms of sleep and its relationships to other conditi…
View article: Investigating the Polygenic Relationship Between Cannabis Use and Schizophrenia in the All of Us Research Program
Investigating the Polygenic Relationship Between Cannabis Use and Schizophrenia in the All of Us Research Program Open
Objective Decades of research have identified a strong association between heavy cannabis use and schizophrenia, with evidence of correlated genetic factors. However, many studies on the genetic relationship between cannabis use and psycho…
View article: Real-world effectiveness of antipsychotic medication in relapse prevention after cannabis-induced psychosis
Real-world effectiveness of antipsychotic medication in relapse prevention after cannabis-induced psychosis Open
Background Cannabis use is linked to treatment non-adherence and relapses in psychotic disorders. Antipsychotic medication is effective for relapse prevention in primary psychoses, but its effectiveness after cannabis-induced psychosis (CI…
View article: Sex differences in schizophrenia spectrum disorders: insights from the DiAPAson study using a data-driven approach
Sex differences in schizophrenia spectrum disorders: insights from the DiAPAson study using a data-driven approach Open
View article: First-Episode Psychosis incidence pre-, during, and post-COVID-19 pandemic: a six-year natural quasi-experimental study in South London
First-Episode Psychosis incidence pre-, during, and post-COVID-19 pandemic: a six-year natural quasi-experimental study in South London Open
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View article: Salivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis
Salivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis Open
Clinical high-risk and first-episode psychosis participants differed from healthy controls in the peak-to-evening diurnal cortisol slope. This measure has not been examined in these populations before, and its potential predictive and prog…
View article: Cannabis Use Cessation and the Risk of Psychotic Disorders: A Case–Control Analysis from the First Episode Case–Control EU-GEI WP2 Study: L’arrêt de l’utilisation du cannabis et le risque de troubles psychotiques: Une analyse cas-témoins tirée de l’étude cas-témoins EU-GEI WP2 centrée sur les premiers épisodes psychotiques
Cannabis Use Cessation and the Risk of Psychotic Disorders: A Case–Control Analysis from the First Episode Case–Control EU-GEI WP2 Study: L’arrêt de l’utilisation du cannabis et le risque de troubles psychotiques: Une analyse cas-témoins tirée de l’étude cas-témoins EU-GEI WP2 centrée sur les premiers épisodes psychotiques Open
Objectives To establish whether the risk of psychotic disorders in cannabis users changes with time following cannabis cessation using data from the European Network of National Networks studying Gene–Environment Interactions in Schizophre…
View article: The impact of childhood trauma and cannabis use on paranoia: a structural equation model approach
The impact of childhood trauma and cannabis use on paranoia: a structural equation model approach Open
Background Childhood trauma is a well-established risk factor for psychosis, paranoia, and substance use, with cannabis being a modifiable environmental factor that exacerbates these vulnerabilities. This study examines the interplay betwe…
View article: Human development, inequality, and their associations with brain structure across 29 countries
Human development, inequality, and their associations with brain structure across 29 countries Open
Background The macro-social and environmental conditions in which people live, such as the level of a country’s development or inequality, are associated with brain-related disorders. However, the relationship between these systemic enviro…
View article: Cognitive presentation at psychosis onset through premorbid deterioration and exposure to environmental risk factors
Cognitive presentation at psychosis onset through premorbid deterioration and exposure to environmental risk factors Open
Background Previous studies identified clusters of first-episode psychosis (FEP) patients based on cognition and premorbid adjustment. This study examined a range of socio-environmental risk factors associated with clusters of FEP, aiming …
View article: A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders
A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders Open
Background Cannabis use severely affects the outcome of people with psychotic disorders, yet there is a lack of treatments. To address this, in 2019 the National Health Service (NHS) Cannabis Clinic for Psychosis (CCP) was developed to sup…
View article: Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study
Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study Open
Background Multiple genetic and environmental risk factors play a role in the development of both schizophrenia-spectrum disorders and affective psychoses. How they act in combination is yet to be clarified. Methods We analyzed 573 first e…
View article: Pathways to care: Source of referral at first-episode psychosis, a cross-country comparison between Bologna and South London
Pathways to care: Source of referral at first-episode psychosis, a cross-country comparison between Bologna and South London Open
View article: The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies
The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies Open
Background The association between cannabis and psychosis is established, but the role of underlying genetics is unclear. We used data from the EU-GEI case-control study and UK Biobank to examine the independent and combined effect of heav…
View article: Variation of subclinical psychosis as a function of population density across different European settings: Findings from the multi‐national <scp>EU</scp> ‐ <scp>GEI</scp> study
Variation of subclinical psychosis as a function of population density across different European settings: Findings from the multi‐national <span>EU</span> ‐ <span>GEI</span> study Open
Background Urbanicity is a well‐established risk factor for psychosis. Our recent multi‐national study found an association between urbanicity and clinical psychosis in Northern Europe but not in Southern Europe. In this study, we hypothes…
View article: Cannabis use and cognitive biases in people with first-episode psychosis and their siblings
Cannabis use and cognitive biases in people with first-episode psychosis and their siblings Open
Background Cannabis use and familial vulnerability to psychosis have been associated with social cognition deficits. This study examined the potential relationship between cannabis use and cognitive biases underlying social cognition and f…
View article: The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis
The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis Open
View article: Methylomic signature of current cannabis use in two first-episode psychosis cohorts
Methylomic signature of current cannabis use in two first-episode psychosis cohorts Open
The rising prevalence and legalisation of cannabis worldwide have underscored the need for a comprehensive understanding of its biological impact, particularly on mental health. Epigenetic mechanisms, specifically DNA methylation, have gai…
View article: Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT)
Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT) Open
Background A clinical tool to estimate the risk of treatment-resistant schizophrenia (TRS) in people with first-episode psychosis (FEP) would inform early detection of TRS and overcome the delay of up to 5 years in starting TRS medication.…
View article: Systematic review and meta-analysis on the effects of chronic peri-adolescent cannabinoid exposure on schizophrenia-like behaviour in rodents
Systematic review and meta-analysis on the effects of chronic peri-adolescent cannabinoid exposure on schizophrenia-like behaviour in rodents Open
Background The link between cannabis use and schizophrenia is well-established in epidemiological studies, especially among adolescents with early-onset use. However, this association in rodent models is less clear. This meta-analysis exam…
View article: Corrigendum to “Cognitive performance at first episode of psychosis and the relationship with future treatment resistance: Evidence from an international prospective cohort study” [Schizophr. Res. volume 225 (May 2023) 173–181]
Corrigendum to “Cognitive performance at first episode of psychosis and the relationship with future treatment resistance: Evidence from an international prospective cohort study” [Schizophr. Res. volume 225 (May 2023) 173–181] Open
View article: Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking
Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking Open
Individuals with schizophrenia frequently experience co-occurring substance use, including tobacco smoking and heavy cannabis use, and substance use disorders. There is interest in understanding the extent to which these relationships are …
View article: The Role of Social Deprivation and Cannabis Use in Explaining Variation in the Incidence of Psychotic Disorders: Findings From the EU-GEI Study
The Role of Social Deprivation and Cannabis Use in Explaining Variation in the Incidence of Psychotic Disorders: Findings From the EU-GEI Study Open
Background and Hypothesis Recent findings suggest the incidence of first-episode psychotic disorders (FEP) varies according to setting-level deprivation and cannabis use, but these factors have not been investigated together. We hypothesiz…