Marta J. Koper
YOU?
Author Swipe
View article: Correction: Pyroptosis in Alzheimer’s disease: cell type‑specific activation in microglia, astrocytes and neurons
Correction: Pyroptosis in Alzheimer’s disease: cell type‑specific activation in microglia, astrocytes and neurons Open
View article: Genome‐wide investigation of a neuropathological cohort offers novel insights in the genetic risk underlying hallmark and co‐morbid lesions implicated in Alzheimer’s disease
Genome‐wide investigation of a neuropathological cohort offers novel insights in the genetic risk underlying hallmark and co‐morbid lesions implicated in Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is a heterogenous disease with a strong heritability. Genetic studies are of irreplaceable value in elucidating the mechanisms that underly this disease. The classical genome‐wide association studies (GW…
View article: The inhibition of necroptosis prevents neuronal death in a mouse model of Alzheimer’s disease pathology
The inhibition of necroptosis prevents neuronal death in a mouse model of Alzheimer’s disease pathology Open
Background As neurodegenerative diseases advance, postmitotic neurons are affected by disturbed proteostasis and the accumulation of misfolded proteins. This renders neurons sensitive to cell death, ultimately leading to progressive neuron…
View article: Single nucleotide polymorphisms linked to Alzheimer’s disease are associated with distinct neuropathological phenotypes
Single nucleotide polymorphisms linked to Alzheimer’s disease are associated with distinct neuropathological phenotypes Open
Background Neurodegenerative brain diseases (NBDs) ultimately result in neuronal loss and subsequent cognitive decline. In Alzheimer’s disease, tau neurofibrillary tangles (NFT) and amyloid plaques are considered as the hallmark lesions, b…
View article: Ponatinib and dabrafenib reduce the accumulation of necroptosis‐related proteins and neuronal loss in APP23xTAU58 mice.
Ponatinib and dabrafenib reduce the accumulation of necroptosis‐related proteins and neuronal loss in APP23xTAU58 mice. Open
Background Neuronal death is the result of the neurodegenerative process in Alzheimer’s disease (AD). Both histopathological hallmark lesions of AD, i.e., amyloid plaques and neurofibrillary tangles, are associated with reduced numbers of …
View article: Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology
Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology Open
Aging is the main risk factor for Alzheimer’s disease (AD) and other neurodegenerative pathologies, but the molecular and cellular changes underlying pathological aging of the nervous system are poorly understood. AD pathology seems to cor…
View article: Pyroptosis in Alzheimer’s disease: cell type-specific activation in microglia, astrocytes and neurons
Pyroptosis in Alzheimer’s disease: cell type-specific activation in microglia, astrocytes and neurons Open
The major neuropathological hallmarks of Alzheimer's disease (AD) are amyloid β (Aβ) plaques and neurofibrillary tangles (NFT), accompanied by neuroinflammation and neuronal loss. Increasing evidence is emerging for the activation of the c…
View article: LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease
LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease Open
View article: Seeding, maturation and propagation of amyloid β-peptide aggregates in Alzheimer’s disease
Seeding, maturation and propagation of amyloid β-peptide aggregates in Alzheimer’s disease Open
Alzheimer’s disease is neuropathologically characterized by the deposition of the amyloid β-peptide (Aβ) as amyloid plaques. Aβ plaque pathology starts in the neocortex before it propagates into further brain regions. Moreover, Aβ aggregat…
View article: Impact of the presence of Aβ<sub>N3pE</sub> and Aβ<sub>pSer8</sub> in Aβ aggregates on the induction of Aβ seeding and spreading in the brains of APP23 mice
Impact of the presence of Aβ<sub>N3pE</sub> and Aβ<sub>pSer8</sub> in Aβ aggregates on the induction of Aβ seeding and spreading in the brains of APP23 mice Open
Background Amyloid β‐plaques are a hallmark lesion of Alzheimer’s disease (AD) and consist of aggregates of the amyloid β‐peptide (Aβ). Aβ peptides can undergo posttranslational modifications, including N‐terminal truncation with subsequen…
View article: Hierarchical involvement of molecular players in human neocortex in the course of preclinical and symptomatic Alzheimer’s disease
Hierarchical involvement of molecular players in human neocortex in the course of preclinical and symptomatic Alzheimer’s disease Open
Background Proteomic profile changes have been reported in the brains from individuals having Alzheimer’s disease. However, it is not yet clear whether they represent a continuous process from mild to severe changes, or whether the protein…
View article: Alzheimer’s disease‐related necroptotic pathology: An exclusive presence of the necrosome in granulovacuolar degeneration inclusions in human and transgenic mouse brains
Alzheimer’s disease‐related necroptotic pathology: An exclusive presence of the necrosome in granulovacuolar degeneration inclusions in human and transgenic mouse brains Open
Background Alzheimer’s disease (AD) is characterized by pathological processes such as β‐amyloid (Aβ) plaques, neurofibrillary tangles (NFT), cytoplasmic granulovacuolar degeneration (GVD) lesions and neuronal loss that underpin cognitivea…
View article: Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease
Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease Open
Alzheimer's disease (AD) is characterized by a specific pattern of neuropathological changes, including extracellular amyloid β (Aβ) deposits, intracellular neurofibrillary tangles (NFTs), granulovacuolar degeneration (GVD) representing cy…