Marta Llovera
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View article: TRLS-02 CEREBROSPINAL FLUID-DERIVED TUMOR REACTIVE T CELLS (CSF-TRT CELLS) FOR THE TREATMENT OF MELANOMA LEPTOMENINGEAL DISEASE.
TRLS-02 CEREBROSPINAL FLUID-DERIVED TUMOR REACTIVE T CELLS (CSF-TRT CELLS) FOR THE TREATMENT OF MELANOMA LEPTOMENINGEAL DISEASE. Open
BACKGROUND Leptomeningeal disease (LMD), a devastating complication of metastatic cancers, has a median survival of weeks to a few months. LMD incidence is highest in melanoma (5-25%), carrying the worst prognosis. Adoptive cell therapy (A…
View article: Mammalian <scp>TatD DNase</scp> domain containing 1 ( <i>TATDN1</i> ) is a proteostasis‐responsive gene with roles in ventricular structure and neuromuscular function
Mammalian <span>TatD DNase</span> domain containing 1 ( <i>TATDN1</i> ) is a proteostasis‐responsive gene with roles in ventricular structure and neuromuscular function Open
The characterization of highly conserved but poorly understood genes often reveals unexpected biological roles, advancing our understanding of disease mechanisms. One such gene is Mammalian TatD DNase domain containing 1 ( Tatdn1 ), the ma…
View article: The effects of ENDOG on lipid metabolism may be tissue-dependent and may not require its translocation from mitochondria
The effects of ENDOG on lipid metabolism may be tissue-dependent and may not require its translocation from mitochondria Open
View article: TATDN1, the Mammalian Ortholog of TATD, is a Cytoplasmic Protein Important for Cardiac Structure and Motor Coordination
TATDN1, the Mammalian Ortholog of TATD, is a Cytoplasmic Protein Important for Cardiac Structure and Motor Coordination Open
View article: Cardiac fibroblasts display endurance to ischemia, high ROS control and elevated respiration regulated by the JAK2/STAT pathway
Cardiac fibroblasts display endurance to ischemia, high ROS control and elevated respiration regulated by the JAK2/STAT pathway Open
Cardiovascular diseases are the leading cause of death globally and more than four out of five cases are due to ischemic events. Cardiac fibroblasts (CF) contribute to normal heart development and function, and produce the post‐ischemic sc…
View article: ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status
ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status Open
EndoG influences mitochondrial DNA replication and is involved in somatic cell proliferation. Here, we investigated the effect of ENDOG/Endog expression on proliferation in different tumor models. Noteworthy, ENDOG deficiency reduced proli…
View article: Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia
Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia Open
Friedreich ataxia (FA) is a neurodegenerative disease caused by the deficiency of frataxin, a mitochondrial protein. In primary cultures of dorsal root ganglia neurons, we showed that frataxin depletion resulted in decreased levels of the …
View article: Involvement of the mitochondrial nuclease EndoG in the regulation of cell proliferation through the control of reactive oxygen species
Involvement of the mitochondrial nuclease EndoG in the regulation of cell proliferation through the control of reactive oxygen species Open
The apoptotic nuclease EndoG is involved in mitochondrial DNA replication. Previous results suggested that, in addition to regulate cardiomyocyte hypertrophy, EndoG could be involved in cell proliferation. Here, by using in vivo and cell c…
View article: Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin
Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin Open
View article: Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart
Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart Open
Executioner caspase-3 and -7 are proteases promoting cell death but non-apoptotic roles are being discovered. The heart expresses caspases only during development, suggesting they contribute to the organ maturation process. Therefore, we a…