Marta Melis
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View article: Age and Witnessed Apneas as Independent Predictors of Obstructive Sleep Apnea After Stroke: A Prospective Cohort Study
Age and Witnessed Apneas as Independent Predictors of Obstructive Sleep Apnea After Stroke: A Prospective Cohort Study Open
Background: Obstructive sleep apnea (OSA) is frequent but underrecognized after stroke, worsening prognosis, recurrence, and mortality. Polysomnography is rarely feasible in acute care, and existing screening tools have limited accuracy. W…
View article: Prevalence of Fabry disease and GLA variants in young patients with acute stroke: The challenge to widen the screening. The Fabry-Stroke Italian Registry
Prevalence of Fabry disease and GLA variants in young patients with acute stroke: The challenge to widen the screening. The Fabry-Stroke Italian Registry Open
View article: Carotid stenosis and cryptogenic stroke
Carotid stenosis and cryptogenic stroke Open
View article: Mechanism and Effect of HNF4α Decrease in a Rat Model of Cirrhosis and Liver Failure
Mechanism and Effect of HNF4α Decrease in a Rat Model of Cirrhosis and Liver Failure Open
Liver decompensation by inflammatory STAT3 and NFκB signaling was not a direct consequence of progressive cirrhosis. Despite significant reduction of Hnf4a expression, residual levels of this abundant TF still stimulated strong new gene ex…
View article: Retinoic Acid Receptor β Loss in Hepatocytes Increases Steatosis and Elevates the Integrated Stress Response in Alcohol-Associated Liver Disease
Retinoic Acid Receptor β Loss in Hepatocytes Increases Steatosis and Elevates the Integrated Stress Response in Alcohol-Associated Liver Disease Open
In alcohol-associated liver disease (ALD), hepatic reductions in vitamin A and perturbations in vitamin A metabolism are common. However, the roles that the vitamin A receptors, termed retinoic acid receptors (RARs), may have in preventing…
View article: Retinoic Acid Receptor β Loss in Hepatocytes Increases Steatosis and Elevates the Integrated Stress Response in Alcohol-Associated Liver Disease
Retinoic Acid Receptor β Loss in Hepatocytes Increases Steatosis and Elevates the Integrated Stress Response in Alcohol-Associated Liver Disease Open
Supplementary data for ijms-2482914 after proofreading.
View article: Retinoic Acid Receptor β Loss in Hepatocytes Increases Steatosis and Elevates the Integrated Stress Response in Alcohol-Associated Liver Disease
Retinoic Acid Receptor β Loss in Hepatocytes Increases Steatosis and Elevates the Integrated Stress Response in Alcohol-Associated Liver Disease Open
Abstract: In alcohol-associated liver disease (ALD), hepatic reductions of vitamin A and perturbations in vitamin A metabolism are common. However, the roles that the vitamin A receptors, retinoic acid receptors (RARs), ma…
View article: Figure S2 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S2 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Genes associated with the twenty top-scored pathways of malignant hepatocytes of HDV-HCC.
View article: Data from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Data from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
There is limited data on the molecular mechanisms whereby hepatitis D virus (HDV) promotes liver cancer. Therefore, serum and liver specimens obtained at the time of liver transplantation from well-characterized patients with HDV-HCC (n…
View article: Figure S3 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S3 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Synopsis of the 20 top-scored pathways associated with genes identified in malignant hepatocytes derived from HDV-, HBV- and HCV-HCC.
View article: Figure S1 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S1 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Experimental design.
View article: Figure S2 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S2 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Genes associated with the twenty top-scored pathways of malignant hepatocytes of HDV-HCC.
View article: Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
HBV DNA levels in tumorous and non-tumorous tissues of individual patients with HBV-associated HCC.
View article: Figure S6 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S6 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Synopsis of the 20 top-scored pathways associated with WLT-unique genes identified in the three tumors.
View article: Figure S4 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S4 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Clusters of the 37 genes involved in the cell cycle and differentially expressed in malignant hepatocytes derived from HDV-HCC.
View article: Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
HBV DNA levels in tumorous and non-tumorous tissues of individual patients with HBV-associated HCC.
View article: Figure S4 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S4 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Clusters of the 37 genes involved in the cell cycle and differentially expressed in malignant hepatocytes derived from HDV-HCC.
View article: Figure S5 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S5 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Venn diagrams of differentially expressed genes obtained from laser capture microdissected hepatocytes and whole liver tissue of patients with HDV-, HBV-and HCV-associated HCC
View article: Figure S5 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S5 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Venn diagrams of differentially expressed genes obtained from laser capture microdissected hepatocytes and whole liver tissue of patients with HDV-, HBV-and HCV-associated HCC
View article: Figure S6 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S6 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Synopsis of the 20 top-scored pathways associated with WLT-unique genes identified in the three tumors.
View article: Figure S1 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S1 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Experimental design.
View article: Figure S3 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S3 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Synopsis of the 20 top-scored pathways associated with genes identified in malignant hepatocytes derived from HDV-, HBV- and HCV-HCC.
View article: Data from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Data from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
There is limited data on the molecular mechanisms whereby hepatitis D virus (HDV) promotes liver cancer. Therefore, serum and liver specimens obtained at the time of liver transplantation from well-characterized patients with HDV-HCC (n…
View article: Retinoids in the Pathogenesis and Treatment of Liver Diseases
Retinoids in the Pathogenesis and Treatment of Liver Diseases Open
Vitamin A (VA), all-trans-retinol (ROL), and its analogs are collectively called retinoids. Acting through the retinoic acid receptors RARα, RARβ, and RARγ, all-trans-retinoic acid, an active metabolite of VA, is a potent regulator of nume…
View article: Fenretinide Reduces Intestinal Mucin-2-Positive Goblet Cells in Chronic Alcohol Abuse
Fenretinide Reduces Intestinal Mucin-2-Positive Goblet Cells in Chronic Alcohol Abuse Open
Introduction: Alcohol-induced thickening of the gut mucosal layer and increased expression of goblet cell gel-forming mucins, such as mucin-2 (MUC2) are associated with disruptions to the gut barrier in alcoholic liver…
View article: Supplementary Material for: Fenretinide Reduces Intestinal Mucin-2-Positive Goblet Cells in Chronic Alcohol Abuse
Supplementary Material for: Fenretinide Reduces Intestinal Mucin-2-Positive Goblet Cells in Chronic Alcohol Abuse Open
Introduction: Alcohol-induced thickening of the gut mucosal layer and increased expression of goblet cell gel-forming mucins, such as mucin-2 (MUC2) are associated with disruptions to the gut barrier in alcoholic liver…
View article: A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes
A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes Open
Alcohol abuse reduces hepatic vitamin A (retinoids), reductions that are associated with progression of alcohol liver disease (ALD). Restoring hepatic retinoids through diet is contraindicated in ALD due to the negative effects of alcohol …
View article: A retinoic acid receptor β2 agonist attenuates transcriptome and metabolome changes underlying nonalcohol-associated fatty liver disease
A retinoic acid receptor β2 agonist attenuates transcriptome and metabolome changes underlying nonalcohol-associated fatty liver disease Open
View article: Fabry-Stroke Italian Registry (FSIR): a nationwide, prospective, observational study about incidence and characteristics of Fabry-related stroke in young-adults. Presentation of the study protocol
Fabry-Stroke Italian Registry (FSIR): a nationwide, prospective, observational study about incidence and characteristics of Fabry-related stroke in young-adults. Presentation of the study protocol Open
View article: Fenretinide Improves Intestinal Barrier Function and Mitigates Alcohol Liver Disease
Fenretinide Improves Intestinal Barrier Function and Mitigates Alcohol Liver Disease Open
Alcohol liver disease (ALD) is a major cause of liver-related mortality globally, yet there remains an unmet demand for approved ALD drugs. The pathogenesis of ALD involves perturbations to the intestinal barrier and subsequent translocati…